Liquid Chromatographic Determination of Flucytosine in Capsules
Keyword(s):
Abstract A liquid chromatographic method has been developed for determination of flucytosine in capsules. Flucytosine and p-aminobenzoic acid, the internal standard, are separated on a C18 reverse phase column using water-methanol-acetic acid mobile phase containing 1-octanesulfonic acid sodium salt. Compounds are detected photometrically at 285 nm. Mean assay results for 250 and 500 mg commercial capsules were 101.5% (n = 5) and 100.2% (n = 5) of declared, respectively. Mean recovery of flucytosine added to commercial capsules was 99.3 %.
1997 ◽
Vol 80
(2)
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pp. 331-334
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1990 ◽
Vol 73
(6)
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pp. 893-895
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1985 ◽
Vol 68
(3)
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pp. 596-598
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