Liquid Chromatographic Determination of Propranolol Hydrochloride in Various Dosage Forms
Keyword(s):
Abstract A simple and rapid liquid chromatographic method is described for the determination of propranolol hydrochloride in pharmaceutical preparations. The separation was achieved on a reverse-phase octylsilane (C8) column by using a mobile phase composed of a mixture of 0.5 g dodecyl sodium sulfate in 18 mL (0.15 M) H3P04 plus 90 mL methanol, 90 mL acetonitrile, and 52 mL water. Detector response was linear for 0.03-3.1 mg/mL of propranolol. Recoveries from synthetic mixtures ranged from 99.6 to 101.7%. The results obtained by the proposed method were similar to those obtained by the USP XXI method.
1986 ◽
Vol 69
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pp. 169-173
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1989 ◽
Vol 72
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pp. 231-234
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1995 ◽
Vol 78
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pp. 307-309
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1984 ◽
Vol 67
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pp. 225-227
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1987 ◽
Vol 70
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pp. 1008-1011
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