Molecular Breast Imaging: A Scientific Review

2021 ◽  
Author(s):  
Katie N Hunt
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Breast Mri ◽  
Cancer Staging ◽  
Scientific Review ◽  
Molecular Breast Imaging ◽  
Breast Cancer Staging ◽  
Fast Learning ◽  
Technical Advances ◽  
History Of

Abstract Molecular breast imaging (MBI) is a nuclear medicine technique that has evolved considerably over the past two decades. Technical advances have allowed reductions in administered doses to the point that they are now acceptable for screening. The most common radiotracer used in MBI, 99mTc-sestamibi, has a long history of safe use. Biopsy capability has become available in recent years, with early clinical experience demonstrating technically successful biopsies of MBI-detected lesions. MBI has been shown to be an effective supplemental screening tool in women with dense breasts and is also utilized for breast cancer staging, assessment of response to neoadjuvant chemotherapy, problem solving, and as an alternative to breast MRI in women who have a contraindication to MRI. The degree of background parenchymal uptake on MBI shows promise as a tool for breast cancer risk stratification. Radiologist interpretation is guided by a validated MBI lexicon that mirrors the BI-RADS lexicon. With short interpretation times, a fast learning curve for radiologists, and a substantially lower cost than breast MRI, MBI provides many benefits in the practices in which it is utilized. This review will discuss the current state of MBI technology, clinical applications of MBI, MBI interpretation, radiation dose associated with MBI, and the future of MBI.

scholarly journals Breast Imaging During Pregnancy and Lactation

2019 ◽  
Vol 1 (4) ◽  
pp. 342-351
Author(s):  
Lisa Abramson ◽  
Lindsey Massaro ◽  
J Jaime Alberty-Oller ◽  
Amy Melsaether
Keyword(s):  
Breast Cancer ◽  
Breast Imaging ◽  
Treatment Options ◽  
Nipple Discharge ◽  
Cancer Staging ◽  
Imaging Features ◽  
Breast Cancers ◽  
Bloody Nipple Discharge ◽  
Breast Cancer Staging ◽  
Pregnancy And Lactation

Abstract Breast imaging during pregnancy and lactation is important in order to avoid delays in the diagnosis and treatment of pregnancy-associated breast cancers. Radiologists have an opportunity to improve breast cancer detection by becoming familiar with appropriate breast imaging and providing recommendations to women and their referring physicians. Importantly, during pregnancy and lactation, both screening and diagnostic breast imaging can be safely performed. Here we describe when and how to screen, how to work up palpable masses, and evaluate bloody nipple discharge. The imaging features of common findings in the breasts of pregnant and lactating women are also reviewed. Finally, we address breast cancer staging and provide a brief primer on treatment options for pregnancy-associated breast cancers.

Report of the Working Groups on Breast MRI: Report of the Breast Cancer Staging Group

2004 ◽  
Vol 10 (s2) ◽  
pp. S3-S8 ◽  
Author(s):  
Steven E. Harms ◽  
Rachel Rabinovitch ◽  
Thomas B. Julian ◽  
Elizabeth Rafferty ◽  
Shahla Masood ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Mri ◽  
Cancer Staging ◽  
Breast Cancer Staging ◽  
Working Groups

Diagnostic Breast Imaging and Breast Cancer Staging

2019 ◽  
Author(s):  
Nidhi Sharma
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Breast Imaging ◽  
Breast Mri ◽  
Cancer Staging ◽  
The United States ◽  
Patient Treatment ◽  
Architectural Distortion ◽  
Diagnostic Modality ◽  
Cancer Breast

This review is geared to provide surgeons practical insight on breast imaging, intended to improve breast cancer detection and staging. Breast cancer is a leading cause of death in women in the United States. The American Joint Committee on Cancer staging system provides a tumor-node-metastasis classification that helps in determining prognosis and patient treatment. There is an increasing role of radiologists in ascertaining the correct cancer stage. Screening mammography is the basic tool and most widely used modality to detect breast cancer. The diagnostic work-up of a patient recalled from screening is the next step in assessing the artifacts and benign findings from more suspicious lesions. Additional mammographic views, tomosynthesis, and ultrasonography play an important role in determining if the finding represents a true lesion and if so, to localize and determine its level of suspicion to be cancer. Breast MRI is used both as a screening tool and a diagnostic modality to help in cancer detection and treatment planning. Recognizing patterns of benign masses, malignant calcifications, architectural distortion, and masses via a multimodality approach is the essential first step in further diagnosis. A quick overview of common interventional breast procedures may serve as a practical reference for the readers. This review contains 10 figures, 8 tables, and 39 references. Key Words: breast cancer, breast MRI, breast ultrasonography, fibroadenoma, invasive ductal staging, male breast, mammograms, postoperative breast, screening

Diagnostic Breast Imaging and Breast Cancer Staging

2019 ◽  
Author(s):  
Nidhi Sharma
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Breast Imaging ◽  
Breast Mri ◽  
Cancer Staging ◽  
The United States ◽  
Patient Treatment ◽  
Architectural Distortion ◽  
Diagnostic Modality ◽  
Cancer Breast

This review is geared to provide surgeons practical insight on breast imaging, intended to improve breast cancer detection and staging. Breast cancer is a leading cause of death in women in the United States. The American Joint Committee on Cancer staging system provides a tumor-node-metastasis classification that helps in determining prognosis and patient treatment. There is an increasing role of radiologists in ascertaining the correct cancer stage. Screening mammography is the basic tool and most widely used modality to detect breast cancer. The diagnostic work-up of a patient recalled from screening is the next step in assessing the artifacts and benign findings from more suspicious lesions. Additional mammographic views, tomosynthesis, and ultrasonography play an important role in determining if the finding represents a true lesion and if so, to localize and determine its level of suspicion to be cancer. Breast MRI is used both as a screening tool and a diagnostic modality to help in cancer detection and treatment planning. Recognizing patterns of benign masses, malignant calcifications, architectural distortion, and masses via a multimodality approach is the essential first step in further diagnosis. A quick overview of common interventional breast procedures may serve as a practical reference for the readers. This review contains 10 figures, 8 tables, and 39 references. Key Words: breast cancer, breast MRI, breast ultrasonography, fibroadenoma, invasive ductal staging, male breast, mammograms, postoperative breast, screening

Comparison of99mTc-Sestamibi Molecular Breast Imaging and Breast MRI in Patients With Invasive Breast Cancer Receiving Neoadjuvant Chemotherapy

2019 ◽  
Vol 213 (4) ◽  
pp. 932-943 ◽  
Author(s):  
Katie N. Hunt ◽  
Amy Lynn Conners ◽  
Matthew P. Goetz ◽  
Michael K. O'Connor ◽  
Vera Suman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Invasive Breast Cancer ◽  
Breast Imaging ◽  
Breast Mri ◽  
Molecular Breast Imaging

Increased Use of MRI for Breast Cancer Surveillance and Staging is Not Associated with Increased Rate of Mastectomy

2009 ◽  
Vol 75 (10) ◽  
pp. 937-940
Author(s):  
Catherine M. Dang ◽  
Karen Zaghiyan ◽  
Scott R. Karlan ◽  
Edward H. Phillips
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Early Stage ◽  
Preoperative Staging ◽  
Breast Mri ◽  
Cancer Staging ◽  
Breast Conserving Surgery ◽  
Cancer Surveillance ◽  
Breast Cancer Staging ◽  
Time Period

The use of MRI in preoperative staging of breast cancer has escalated recently. Breast MRI has greater sensitivity than mammography, ultrasound, and clinical examination in cancer detection. Because of its variable specificity, however, there has been concern that increased MRI use will result in increased rates of mastectomy for early-stage breast cancer. We postulated that mastectomy rates are not affected by trends in MRI use. We performed a retrospective analysis of imaging tests ordered by surgeons at our breast center from 2003 to 2007. We also reviewed all breast cancer cases reported to the National Cancer Database from our institution during the same time period and categorized them as having been treated with mastectomy or breast-conserving surgery. From 2003 to 2007, the number of breast MRIs ordered annually by surgeons increased from 68 to 358. The rate of MRI use increased from 4.1 per every 100 patients seen to 5.7 and from 1.6 per every 100 new patients seen to 2.9. The percentage of women undergoing mastectomy for breast cancer remained unchanged during this 5-year interval. Therefore, although MRI use in breast cancer staging and surveillance has increased, mastectomy rates have not.

scholarly journals The Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer

2012 ◽  
Vol 37 (4) ◽  
pp. 344-350 ◽  
Author(s):  
Dietlind L. Wahner-Roedler ◽  
Judy C. Boughey ◽  
Carrie B. Hruska ◽  
Beiyun Chen ◽  
Deborah J. Rhodes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Therapy ◽  
Breast Imaging ◽  
Molecular Breast Imaging
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