The Effect of Protein-Energy Malnutrition on the Development of Bones in Newborn Rats

1979 ◽  
Vol 109 (8) ◽  
pp. 1469-1476 ◽  
Author(s):  
Tetsuo Nakamoto ◽  
Sanford A. Miller
1979 ◽  
Vol 58 (3) ◽  
pp. 1115-1122 ◽  
Author(s):  
Tetsuo Nakamoto ◽  
Henry M. Mallak ◽  
Sanford A. Miller

1983 ◽  
Vol 50 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Tetsuo Nakamoto ◽  
Johnny R. Porter ◽  
Mark M. Winkler

1. To evaluate the role of gestational protein-energy malnutrition on fetal hard-tissue growth and metabolism, we measured several variables in the growth centres of mandibles and long bones of newborn rats.2. Control pups and pups of malnourished dams had approximately the same extent of reduction in body-weight, mandibular weight and long-bone weight.3. The malnourished group had more cells in the mandible although cell size was the same as that of controls.4. In contrast, in the long bones, the malnourished group had fewer cells than did controls whereas cell size was unchanged.5. Calcium content was the same in long bones of both groups, but was less in the mandibles of pups from malnourished dams. Ca metabolism as measured by 45Ca uptake was unchanged in the long bones, but was increased in the mandibles of the malnourished group shortly after birth. Calcification patterns at birth in these bones correlated well with alkaline phosphatase (EC 3.1.3.1) activity.6. These findings indicate that the mandibles and long bones of offspring are affected differently by protein–energy malnutrition during the mother's gestation. Prenatal nutritional stress resulted in a disturbance of the pituitary–adrenal system. Increased adrenal corticosterone could possibly be related to the different observed changes in bone metabolism.


2018 ◽  
Vol 3 (5) ◽  
pp. 79-88
Author(s):  
Abtsam M.F. Badr ◽  
D.A.M. Amer ◽  
M.Y.A. El- Hawary ◽  
A.M.A. Naem

2021 ◽  
Vol 22 (4) ◽  
pp. 1917
Author(s):  
Hiroki Nishikawa ◽  
Hirayuki Enomoto ◽  
Shuhei Nishiguchi ◽  
Hiroko Iijima

The picture of chronic liver diseases (CLDs) has changed considerably in recent years. One of them is the increase of non-alcoholic fatty liver disease. More and more CLD patients, even those with liver cirrhosis (LC), tend to be presenting with obesity these days. The annual rate of muscle loss increases with worsening liver reserve, and thus LC patients are more likely to complicate with sarcopenia. LC is also characterized by protein-energy malnutrition (PEM). Since the PEM in LC can be invariable, the patients probably present with sarcopenic obesity (Sa-O), which involves both sarcopenia and obesity. Currently, there is no mention of Sa-O in the guidelines; however, the rapidly increasing prevalence and poorer clinical consequences of Sa-O are recognized as an important public health problem, and the diagnostic value of Sa-O is expected to increase in the future. Sa-O involves a complex interplay of physiological mechanisms, including increased inflammatory cytokines, oxidative stress, insulin resistance, hormonal disorders, and decline of physical activity. The pathogenesis of Sa-O in LC is diverse, with a lot of perturbations in the muscle–liver–adipose tissue axis. Here, we overview the current knowledge of Sa-O, especially focusing on LC.


Foods ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 221 ◽  
Author(s):  
James Makame ◽  
Tanita Cronje ◽  
Naushad M. Emmambux ◽  
Henriette De Kock

Child malnutrition remains a major public health problem in low-income African communities, caused by factors including the low nutritional value of indigenous/local complementary porridges (CP) fed to infants and young children. Most African children subsist on locally available starchy foods, whose oral texture is not well-characterized in relation to their sensorimotor readiness. The sensory quality of CP affects oral processing (OP) abilities in infants and young children. Unsuitable oral texture limits nutrient intake, leading to protein-energy malnutrition. The perception of the oral texture of selected African CPs (n = 13, Maize, Sorghum, Cassava, Orange-fleshed sweet potato (OFSP), Cowpea, and Bambara) was investigated by a trained temporal-check-all-that-apply (TCATA) panel (n = 10), alongside selected commercial porridges (n = 19). A simulated OP method (Up-Down mouth movements- munching) and a control method (lateral mouth movements- normal adult-like chewing) were used. TCATA results showed that Maize, Cassava, and Sorghum porridges were initially too thick, sticky, slimy, and pasty, and also at the end not easy to swallow even at low solids content—especially by the Up-Down method. These attributes make CPs difficult to ingest for infants given their limited OP abilities, thus, leading to limited nutrient intake, and this can contribute to malnutrition. Methods to improve the texture properties of indigenous CPs are needed to optimize infant nutrient intake.


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