scholarly journals Growth Faltering in Rural Gambian Infants Is Associated with Impaired Small Intestinal Barrier Function, Leading to Endotoxemia and Systemic Inflammation

2003 ◽  
Vol 133 (5) ◽  
pp. 1332-1338 ◽  
Author(s):  
D. I. Campbell ◽  
M. Elia ◽  
P. G. Lunn
Keyword(s):  
Systemic Inflammation ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Growth Faltering ◽  
Small Intestinal

scholarly journals A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

2015 ◽  
Vol 129 (7) ◽  
pp. 529-531 ◽  
Author(s):  
Neil A. Mabbott
Keyword(s):  
Small Intestine ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Human Small Intestine ◽  
Small Intestinal ◽  
Effects Of Aging ◽  
Insight Into

A new study by Man and colleagues provides further insight into the effects of aging on small intestinal barrier function in humans. Here, their findings are briefly summarised and the wider implications discussed.

Proteases and small intestinal barrier function in health and disease

2014 ◽  
Vol 30 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Paolo Giuffrida ◽  
Paolo Biancheri ◽  
Thomas T. MacDonald
Keyword(s):  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Health And Disease ◽  
Small Intestinal

scholarly journals Short intense psychological stress induced by skydiving does not impair intestinal barrier function

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254280
Author(s):  
Maria Fernanda Roca Rubio ◽  
Ulrika Eriksson ◽  
Robert J. Brummer ◽  
Julia König
Keyword(s):  
Psychological Stress ◽  
Intestinal Permeability ◽  
Barrier Function ◽  
Healthy Subjects ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Fatty Acid Binding ◽  
Small Intestinal ◽  
Cortisol Levels ◽  
Psychological Stressor

Background and aim Psychological stress has been shown to increase intestinal permeability and is associated with the development of gastrointestinal disorders. This study aimed to investigate skydiving as an alternative model to analyse the effect of acute psychological stress on intestinal barrier function. Materials and methods Twenty healthy subjects participated in a tandem skydive followed by a negative control visit, of which 19 (9 females and 10 males, 25.9 ± 3.7 years) were included in the study. Intestinal permeability was assessed by a multi-sugar urinary recovery test. Sucrose recovery and lactulose/rhamnose ratio in 0-5h urine indicated gastroduodenal and small intestinal permeability, respectively, and sucralose/erythritol ratio in 5-24h urine indicated colonic permeability. Blood samples were taken to assess markers associated with barrier function. This study has been registered at ClinicalTrials.gov (NCT03644979) on August 23, 2018. Results Skydiving resulted in a significant increase in salivary cortisol levels directly after skydiving compared to the control visit. Cortisol levels were still increased two hours after landing, while cortisol levels before skydiving were not significantly different from the baseline at the control visit. Skydiving did not induce a significant increase in gastroduodenal, small intestinal or colonic permeability. There was also no significant increase in plasma intestinal and liver fatty acid-binding proteins, suggesting no damage to the enterocytes. Discussion These results show that the acute intense psychological stress induced by skydiving does not affect intestinal permeability in healthy subjects. Future models aiming to investigate the effect of stress on human intestinal barrier function should consider a more sustained exposure to the psychological stressor.

Tu1742 Human Small Intestinal Barrier Function and Tight Junction Integrity During Ischemia Reperfusion

2013 ◽  
Vol 144 (5) ◽  
pp. S-835
Author(s):  
Inca H. Hundscheid ◽  
Dirk H. Schellekens ◽  
Joep Grootjans ◽  
Fons K. Verheyen ◽  
Ronald van Dam ◽  
...  
Keyword(s):  
Tight Junction ◽  
Barrier Function ◽  
Ischemia Reperfusion ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Small Intestinal
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