scholarly journals A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

2015 ◽  
Vol 129 (7) ◽  
pp. 529-531 ◽  
Author(s):  
Neil A. Mabbott
Keyword(s):  
Small Intestine ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Human Small Intestine ◽  
Small Intestinal ◽  
Effects Of Aging ◽  
Insight Into

A new study by Man and colleagues provides further insight into the effects of aging on small intestinal barrier function in humans. Here, their findings are briefly summarised and the wider implications discussed.

Increased intestinal barrier function in the small intestine of formula-fed neonatal piglets

2012 ◽  
Vol 90 (suppl_4) ◽  
pp. 315-317 ◽  
Author(s):  
V. Huygelen ◽  
M. De Vos ◽  
S. Willemen ◽  
B. Tambuyzer ◽  
C. Casteleyn ◽  
...  
Keyword(s):  
Small Intestine ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Neonatal Piglets

Proteases and small intestinal barrier function in health and disease

2014 ◽  
Vol 30 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Paolo Giuffrida ◽  
Paolo Biancheri ◽  
Thomas T. MacDonald
Keyword(s):  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Health And Disease ◽  
Small Intestinal

scholarly journals Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-deficient Diet

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 104 ◽  
Author(s):  
Shoji Kawauchi ◽  
Sayo Horibe ◽  
Naoto Sasaki ◽  
Toshihito Tanahashi ◽  
Shigeto Mizuno ◽  
...  
Keyword(s):  
Small Intestine ◽  
Sodium Alginate ◽  
Lipid Accumulation ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Fatty Degeneration ◽  
Intestinal Barrier Function ◽  
Deficient Diet ◽  
Mucus Production ◽  
Nonalcoholic Fatty Liver

Nonalcoholic steatohepatitis (NASH) progresses from nonalcoholic fatty liver disease (NAFLD); however, efficacious drugs for NASH treatment are lacking. Sodium alginate (SA), a soluble dietary fiber extracted from brown algae, could protect the small intestine from enterobacterial invasion. NASH pathogenesis has been suggested to be associated with enterobacterial invasion, so we examined the effect of SA on methionine- and choline-deficient (MCD) diet-induced steatohepatitis in mice (the most widely-used model of NASH). The mice (n = 31) were divided into three groups (mice fed with regular chow, MCD diet, and MCD diet premixed with 5% SA) for 4 and 8 weeks. The MCD diet increased lipid accumulation and inflammation in the liver, the NAFLD Activity Score and hepatic mRNA expression of tumor necrosis factor- and collagen 11, and induced macrophage infiltration. Villus shortening, disruption of zonula occludens-1 localization and depletion of mucus production were observed in the small intestine of the MCD-group mice. SA administration improved lipid accumulation and inflammation in the liver, and impaired barrier function in the small intestine. Collectively, these results suggest that SA is useful for NASH treatment because it can prevent hepatic inflammation and fatty degeneration by maintaining intestinal barrier function.

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