scholarly journals Vitamin B-12 Supplementation during Pregnancy and Early Lactation Does Not Affect Neurophysiologic Outcomes in Children Aged 6 Years

2020 ◽  
Vol 150 (7) ◽  
pp. 1951-1957 ◽  
Author(s):  
Krishnamachari Srinivasan ◽  
Susan Thomas ◽  
Shilpa Anand ◽  
Mahesh Jayachandra ◽  
Tinku Thomas ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Mismatch Negativity ◽  
Controlled Trial ◽  
Event Related Potentials ◽  
P300 Amplitude ◽  
Vitamin B ◽  
Third Trimester ◽  
Related Potentials ◽  
Vitamin B 12 ◽  
The Impact

ABSTRACT Background Deficiency of vitamin B-12 is common in pregnant Indian women. Assessment of neurophysiological measures using event-related potentials (ERPs) may yield additional information on the effects of maternal B-12 supplementation on child brain function. Objectives The objective of the study was to evaluate the effects of vitamin B-12 supplementation (50 μg daily orally) during pregnancy on the childhood ERP measures of positive waveform ∼300 ms after stimulus (P300) and mismatch negativity. Methods This study was a follow-up of children born to pregnant women who received oral vitamin B-12 supplements (n = 62) compared with children of pregnant women who received placebo (n = 70) from a randomized controlled trial. The mean ± SD child age was 72 ± 1 mo. We used the Enobio system to assess the ERP measures P300 and mismatch negativity. Results There were no significant differences in the primary outcomes, amplitudes, and latencies of the P300 results and the mismatch negativity between children in the supplementation and placebo groups. We combined the intervention and placebo groups for secondary analyses. On multiple variable regression analysis after adjusting for treatment group, intrauterine growth restriction, and home environment, P300 amplitude in children was significantly higher in the lowest tertile of third-trimester maternal methylmalonic acid (MMA) concentrations (β = 3034.04; 95% CI: 923.24, 5144.83) compared with the highest MMA tertile (β = 1612.12; 95% CI: −258.86, 3483.10, P = 0.005). Conclusions While no significant effects of maternal vitamin B-12 supplementation on children's ERP measures were seen at 72 mo, elevated maternal MMA concentrations in the third trimester were negatively associated with P300 amplitude in children. It may be worthwhile to study the impact of maternal and infant vitamin B-12 supplementation on childhood brain structure and function in longer and larger trials. The parent trial was registered at clinicaltrials.gov as NCT00641862.

Electrophysiological Correlates of Phonological Processing: A Cross-linguistic Study

2000 ◽  
Vol 12 (4) ◽  
pp. 635-647 ◽  
Author(s):  
G. Dehaene-Lambertz ◽  
E. Dupoux ◽  
A. Gout
Keyword(s):  
Speech Perception ◽  
Speech Processing ◽  
Phonological Processing ◽  
Mismatch Negativity ◽  
Native Language ◽  
Event Related Potentials ◽  
Japanese Adults ◽  
Related Potentials ◽  
Considerable Impact ◽  
The Impact

It is well known that speech perception is deeply affected by the phoneme categories of the native language. Recent studies have found that phonotactics, i.e., constraints on the cooccurrence of phonemes within words, also have a considerable impact on speech perception routines. For example, Japanese does not allow (nonasal) coda consonants. When presented with stimuli that violate this constraint, as in / ebzo/, Japanese adults report that they hear a /u/ between consonants, i.e., /ebuzo/. We examine this phenomenon using event-related potentials (ERPs) on French and Japanese participants in order to study how and when the phonotactic properties of the native language affect speech perception routines. Trials using four similar precursor stimuli were presented followed by a test stimulus that was either identical or different depending on the presence or absence of an epenthetic vowel /u/ between two consonants (e.g., “ebuzo ebuzo ebuzo—ebzo”). Behavioral results confirm that Japanese, unlike French participants, are not able to discriminate between identical and deviant trials. In ERPs, three mismatch responses were recorded in French participants. These responses were either absent or significantly weaker for Japanese. In particular, a component similar in latency and topography to the mismatch negativity (MMN) was recorded for French, but not for Japanese participants. Our results suggest that the impact of phonotactics takes place early in speech processing and support models of speech perception, which postulate that the input signal is directly parsed into the native language phonological format. We speculate that such a fast computation of a phonological representation should facilitate lexical access, especially in degraded conditions.

scholarly journals Event Related Potentials and its role as Endophenotypes in Psychiatry

2014 ◽  
pp. 11-19
Author(s):  
Roshan Khanande ◽  
Bhoomika Sachacher ◽  
B Das ◽  
S H Nizamie
Keyword(s):  
Psychiatric Disorders ◽  
Cognitive Processes ◽  
Mismatch Negativity ◽  
Psychiatric Patients ◽  
Genetic Research ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Related Potentials ◽  
Bipolar Affective Disorders

Familial segregation is a norm rather than an exception in psychiatry. Genetic research has failed to provide much anticipated unanimous, if not awaited answers to the complex predispositions to psychiatric disorders. Hence, the concept of endophenotype took birth. Endophenotype is an attribute which is hidden phenotype, which is described as internal phenotypes discoverable by biochemical test or microscopic examination. This concept was immediately picked up by psychiatry, giving a totally new direction to the search for root cause of various psychiatric disorders.Cognitive deterioration is inseparable from psychiatric disorders, known since dawn of psychiatry. However, cognitive deficits in FDRs (First Degree Relatives) of psychiatric patients were one of the first endophenotypes noted. Event Related Potential (ERP), a science known to be electrophysiological counterpart of various cognitive processes, was soon incorporated in search of endophenotypes in psychiatry. In schizophrenia reduced amplitude of MMN(Mismatch negativity), impaired suppression of P50 and reduced amplitude of P300; reduced P300 amplitude, impaired P50 suppression in Bipolar Affective Disorders; reduced P300 amplitude in substance dependence disorders have been reported to have endophenotypic values. Various other ERP waves such as CNV, N400 have been investigated but no conclusive reports are out yet. The ultimate goal of this science is to search for genes governing the cognitive processes responsible for ERP waves identified as Endophenotypes for specific psychiatric disorders, and the search has just started.Keywords : Event Related Potential, Endophenotype, Psychiatric Disorder, Mismatch negativity,P 300, P 50, CNV

Effects of Experimentally Induced Pain on Mismatch Negativity

2006 ◽  
Vol 20 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Bruce D. Dick ◽  
John F. Connolly ◽  
Michael E. Houlihan ◽  
Patrick J. McGrath ◽  
G. Allen Finley ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Mismatch Negativity ◽  
Event Related Potentials ◽  
Disruptive Effect ◽  
Ischemic Pain ◽  
Active Attention ◽  
Early Processing ◽  
Related Potentials ◽  
Healthy Participants ◽  
Experimentally Induced

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pain's effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in the active attention condition regardless of pain condition. It appears that rather than exerting a disruptive effect, the presence of experimentally induced pain enhanced early processing of small stimulus differences in these healthy participants.

Human Event-Related Potentials to Higher-Order Acoustic Spatial Changes

2002 ◽  
Vol 16 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Timo Ruusuvirta ◽  
Heikki Hämäläinen
Keyword(s):  
Working Memory ◽  
Mismatch Negativity ◽  
Spatial Information ◽  
Free Field ◽  
Event Related Potentials ◽  
Negative Polarity ◽  
Positive Polarity ◽  
Spatial Changes ◽  
Related Potentials ◽  
Human Event

Abstract Human event-related potentials (ERPs) to a tone continuously alternating between its two spatial loci of origin (middle-standards, left-standards), to repetitions of left-standards (oddball-deviants), and to the tones originally representing these repetitions presented alone (alone-deviants) were recorded in free-field conditions. During the recordings (Fz, Cz, Pz, M1, and M2 referenced to nose), the subjects watched a silent movie. Oddball-deviants elicited a spatially diffuse two-peaked deflection of positive polarity. It differed from a deflection elicited by left-standards and commenced earlier than a prominent deflection of negative polarity (N1) elicited by alone-deviants. The results are discussed in the context of the mismatch negativity (MMN) and previous findings of dissociation between spatial and non-spatial information in auditory working memory.

A randomized controlled trial on the effects of adding vitamin B 12 and folate

2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
N Haiden ◽  
K Klebermass ◽  
F Cardona ◽  
J Schwindt ◽  
A Berger ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vitamin B ◽  
Randomized Controlled ◽  
Vitamin B 12

A randomized controlled trial on the effects of adding vitamin B 12 and folate

2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
N Haiden ◽  
K Klebermass ◽  
F Cardona ◽  
J Schwindt ◽  
A Berger ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Vitamin B ◽  
Randomized Controlled ◽  
Vitamin B 12

scholarly journals Logatome Discrimination in Cochlear Implant Users: Subjective Tests Compared to the Mismatch Negativity

2010 ◽  
Vol 10 ◽  
pp. 329-339 ◽  
Author(s):  
Torsten Rahne ◽  
Michael Ziese ◽  
Dorothea Rostalski ◽  
Roland Mühler
Keyword(s):  
Speech Perception ◽  
Cochlear Implant ◽  
Mismatch Negativity ◽  
Speech Intelligibility ◽  
Event Related Potentials ◽  
Normal Hearing ◽  
Discrimination Test ◽  
Speech Database ◽  
Automated Speech Recognition ◽  
Related Potentials

This paper describes a logatome discrimination test for the assessment of speech perception in cochlear implant users (CI users), based on a multilingual speech database, the Oldenburg Logatome Corpus, which was originally recorded for the comparison of human and automated speech recognition. The logatome discrimination task is based on the presentation of 100 logatome pairs (i.e., nonsense syllables) with balanced representations of alternating “vowel-replacement” and “consonant-replacement” paradigms in order to assess phoneme confusions. Thirteen adult normal hearing listeners and eight adult CI users, including both good and poor performers, were included in the study and completed the test after their speech intelligibility abilities were evaluated with an established sentence test in noise. Furthermore, the discrimination abilities were measured electrophysiologically by recording the mismatch negativity (MMN) as a component of auditory event-related potentials. The results show a clear MMN response only for normal hearing listeners and CI users with good performance, correlating with their logatome discrimination abilities. Higher discrimination scores for vowel-replacement paradigms than for the consonant-replacement paradigms were found. We conclude that the logatome discrimination test is well suited to monitor the speech perception skills of CI users. Due to the large number of available spoken logatome items, the Oldenburg Logatome Corpus appears to provide a useful and powerful basis for further development of speech perception tests for CI users.

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