scholarly journals Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome

2018 ◽  
Vol 8 (3) ◽  
pp. 265-268
Author(s):  
Roman Deniskin ◽  
Brittany Shah ◽  
Flor M Muñoz ◽  
Anthony R Flores
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Toxic Shock Syndrome ◽  
Group A Streptococcus ◽  
Clinical Manifestations ◽  
Streptococcal Toxic Shock Syndrome ◽  
Whole Genome ◽  
Toxic Shock ◽  
Genetic Characteristics ◽  
Group A

Abstract We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group A Streptococcus, the relative contributions of which, in combination with the host response, in the development of streptococcal toxic shock syndrome remain to be elucidated.

scholarly journals AR-12 Has a Bactericidal Activity and a Synergistic Effect with Gentamicin against Group A Streptococcus

2021 ◽  
Vol 22 (21) ◽  
pp. 11617
Author(s):  
Nina Tsao ◽  
Ya-Chu Chang ◽  
Sung-Yuan Hsieh ◽  
Tang-Chi Li ◽  
Ching-Chen Chiu ◽  
...  
Keyword(s):  
Toxic Shock Syndrome ◽  
Group A Streptococcus ◽  
Streptococcal Toxic Shock Syndrome ◽  
Invasive Infection ◽  
Toxic Shock ◽  
Spherical Structures ◽  
Group A ◽  
Bacteria And Fungi

Streptococcus pyogenes (group A Streptococcus (GAS) is an important human pathogen that can cause severe invasive infection, such as necrotizing fasciitis and streptococcal toxic shock syndrome. The mortality rate of streptococcal toxic shock syndrome ranges from 20% to 50% in spite of antibiotics administration. AR-12, a pyrazole derivative, has been reported to inhibit the infection of viruses, intracellular bacteria, and fungi. In this report, we evaluated the bactericidal activities and mechanisms of AR-12 on GAS infection. Our in vitro results showed that AR-12 dose-dependently reduced the GAS growth, and 2.5 μg/mL of AR-12 significantly killed GAS within 2 h. AR-12 caused a remarkable reduction in nucleic acid and protein content of GAS. The expression of heat shock protein DnaK and streptococcal exotoxins was also inhibited by AR-12. Surveys of the GAS architecture by scanning electron microscopy revealed that AR-12-treated GAS displayed incomplete septa and micro-spherical structures protruding out of cell walls. Moreover, the combination of AR-12 and gentamicin had a synergistic antibacterial activity against GAS replication for both in vitro and in vivo infection. Taken together, these novel findings obtained in this study may provide a new therapeutic strategy for invasive GAS infection.

Streptococcal toxic shock syndrome secondary to group A Streptococcus vaginitis

2015 ◽  
Vol 21 (12) ◽  
pp. 873-876 ◽  
Author(s):  
Mayu Hikone ◽  
Ken-ichiro Kobayashi ◽  
Takuya Washino ◽  
Masayuki Ota ◽  
Naoya Sakamoto ◽  
...  
Keyword(s):  
Toxic Shock Syndrome ◽  
Group A Streptococcus ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Group A

scholarly journals Whole-genome sequencing in the investigation of recurrent invasive group A streptococcus outbreaks in a maternity unit

2019 ◽  
Vol 101 (3) ◽  
pp. 320-326 ◽  
Author(s):  
H. Dickinson ◽  
M. Reacher ◽  
B. Nazareth ◽  
H. Eagle ◽  
D. Fowler ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Group A Streptococcus ◽  
Whole Genome ◽  
Maternity Unit ◽  
Invasive Group ◽  
Group A

Group A Streptococcus and hepatitis – streptococcal toxic shock syndrome

2015 ◽  
Vol 04 (03) ◽  
pp. 295-299
Author(s):  
Sanjeev Gupta ◽  
Jarrod Brumby ◽  
Joanna Burton ◽  
Susan Moloney ◽  
Benjamin Kenny
Keyword(s):  
Toxic Shock Syndrome ◽  
Group A Streptococcus ◽  
Streptococcal Toxic Shock Syndrome ◽  
Toxic Shock ◽  
Group A

scholarly journals Primary Peritonitis due to Group A Streptococcus in a Previously Healthy Pediatric Patient

2012 ◽  
Vol 23 (3) ◽  
pp. e69-e70 ◽  
Author(s):  
R Holden ◽  
A Wilmer ◽  
T Kollman
Keyword(s):  
Toxic Shock Syndrome ◽  
Group A Streptococcus ◽  
Present Report ◽  
Blood Cultures ◽  
Streptococcal Toxic Shock Syndrome ◽  
Healthy Children ◽  
Toxic Shock ◽  
Primary Peritonitis ◽  
Pure Cultures ◽  
Group A

Primary peritonitis remains a rare disease in otherwise healthy children, with group A Streptococcus (GAS) being a particularly unusual cause. A case involving a 14-year-old girl, who presented with an ‘acute abdomen’ and was taken to the operating room for urgent laparoscopy, is reported. Abdominal and pelvic structures were only minimally inflamed, as was the appendix. Peritoneal fluid and blood cultures both grew pure cultures of GAS. The patient’s course was complicated by streptococcal toxic shock syndrome. She fortunately made a full recovery. The present report highlights the diagnostic and treatment dilemmas associated with GAS primary peritonitis.

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