scholarly journals Curative resection of a duodenal gastrointestinal stromal tumor in the setting of von Willebrand’s disease

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Kyle Litow ◽  
Gaby Jabbour ◽  
Alexandra Bahn-Humphrey ◽  
Christy Stoller ◽  
Peter Rhee ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Hemorrhage ◽  
Alimentary Tract ◽  
Exploratory Laparotomy ◽  
Stromal Tumor ◽  
Von Willebrand's Disease ◽  
Von Willebrand’S Disease ◽  
Massive Gastrointestinal Hemorrhage ◽  
Emergent Laparotomy ◽  
Common Mesenchymal Tumor

Abstract Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the alimentary tract and usually presents with gastrointestinal hemorrhage. The diagnosis of GIST is typically made with upper endoscopy after excluding other causes of bleeding. The surgical management of GIST can be challenging depending upon the location of the tumor. We present a unique case of duodenal GIST in the setting von Willebrand’s disease diagnosed after emergent laparotomy for massive gastrointestinal hemorrhage. Key strategies in curing our patient were treating the underlying bleeding disorder, collaborating with radiology and gastroenterology teams, and early exploratory laparotomy for refractory hemorrhage. This case demonstrates the challenges of diagnosing and managing GIST in patients with underlying coagulopathies.

A rare cause of gastrointestinal hemorrhage: ileal gastrointestinal stromal tumor

2015 ◽  
Vol 4 (3) ◽  
pp. 301-301
Author(s):  
Barış Yılmaz ◽  
Merih Altıok ◽  
Bora Aktaş ◽  
Bülent Yılmaz ◽  
Fuat Ekiz
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Hemorrhage ◽  
Stromal Tumor

scholarly journals A Case Presentation of Gastrointestinal Stromal Tumor of Duodenum

2021 ◽  
Vol 5 (1) ◽  
pp. 49-53
Author(s):  
Aamir Ghazanfar ◽  
Afifa Asghar ◽  
Farrukh Zaman ◽  
Hassan Mumtaz ◽  
Shahzeb Habib ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Abdominal Distension ◽  
Stromal Tumor ◽  
Palpable Mass ◽  
Case Presentation ◽  
Complete Surgical Resection ◽  
Abdominal Examination ◽  
Duodenal Gists ◽  
The Right ◽  
Common Mesenchymal Tumor

A gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It is caused by the mutation in KIT and PDGFRα genes. It constitutes <1% of all gastrointestinal tumors. Duodenal GISTs constitute 4.5% of all GISTs. We report a 61-year-old lady, presented with generalized abdominal pain, vomiting, abdominal distension, and nausea for the last 3 years. Physical exam-ination showed a pallor and on abdominal examination, a large palpable mass was extending from the pelvis to the right upper quadrant of the abdomen. The CT scan showed a large heterogeneously echogenic mass in the abdomen and pelvis with no lymphadenopathy and distant metastasis in this region. Laparotomy showed a large globular mass extending from the pelvis to the right upper quadrant of the abdomen adherent to the wall of a third part of the duodenum. Complete surgical resection of tumor done with an intact capsule. Microscopic examination showed neoplastic spindle cells with tumor necrosis. An immunohistochemical study confirmed GIST.

scholarly journals Jejunojejunal Intussusception Induced by a Gastrointestinal Stromal Tumor

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Ali H. Zakaria ◽  
Salam Daradkeh
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Exploratory Laparotomy ◽  
Stromal Tumor ◽  
Therapeutic Interventions ◽  
Adult Intussusception ◽  
Lead Point ◽  
Imaging Studies ◽  
High Index Of Suspicion ◽  
Intestinal Obstructions

Background. Adult intussusception is a rare entity representing less than 1% of all intestinal obstructions. Diagnosis of the condition is difficult requiring a high index of suspicion and the utilization of imaging studies, especially CT scans. Diagnostic laparoscopy and/or exploratory laparotomy can be used as a diagnostic and therapeutic intervention. In over 90% of cases, an underlying lead point is identified. In the patient described here, it was a gastrointestinal stromal tumor (GIST), a relatively rare mesenchymal tumor comprising only 0.2–1.0% of the gastrointestinal tract neoplasms and believed to originate from neoplastic transformation of the interstitial cells of Cajal. GISTs may occur anywhere along the gastrointestinal tract, but most commonly arise in the stomach and small intestine. Literature review revealed only few cases reporting GISTs as a leading point of adult's intussusception.Case Presentation. In this report, we are presenting a rare case of jejunojejunal intussusception in a 78-year-old female patient with a GIST located in the terminal jejunum being the leading point, demonstrating the importance of imaging studies, especially CT scan, laparoscopy, and exploratory laparotomy as diagnostic and therapeutic interventions.

scholarly journals Gastrointestinal Stromal Tumor of the Small Bowel: The Forgotten Cause of Massive Obscure Gastrointestinal Hemorrhage

2019 ◽  
Vol 4 (6) ◽  
Author(s):  
Safi Khuri ◽  
Subhi Mansour ◽  
Miriam Obeid ◽  
Kenan Hallon ◽  
Ameer Azzam ◽  
...  
Keyword(s):  
Small Bowel ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Hemorrhage ◽  
Stromal Tumor

scholarly journals Upper gastrointestinal hemorrhage due to duodenal stromal tumor

2003 ◽  
Vol 40 (3) ◽  
pp. 188-191 ◽  
Author(s):  
José Gustavo Parreira ◽  
Wilson de Freitas ◽  
Samir Rasslan
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Hemorrhage ◽  
Emergency Service ◽  
Upper Gastrointestinal Bleeding ◽  
Stromal Tumor ◽  
Post Operative Period ◽  
Heater Probe ◽  
Median Laparotomy ◽  
Upper Gastrointestinal ◽  
Atypical Mitosis

BACKGROUND: Gastrointestinal stromal tumor represents a rare neoplasm that originates in the muscular wall of the hollow viscera. AIM: To report gastrointestinal stromal tumor as a source of upper gastrointestinal bleeding, which required urgent surgical control. PATIENT/METHOD: A man with 61 years old was admitted to the emergency service sustaining hematemesis and melena. Endoscopy showed active bleeding from a tumor in the second portion of the duodenum, which was controlled by heater probe cauterization. Surgery was performed through a median laparotomy. A local resection of a 4 cm tumor in the second portion of the duodenum was carried out, together with a primary end-to-end anastomosis and a duodenal diverticulization. No complications happened during the post-operative period. Morphologic examination showed gastrointestinal stromal tumor with no atypical mitosis and a preserved capsule. CONCLUSION: Albeit not being common, gastrointestinal stromal tumors can represent a source of substantial gastrointestinal hemorrhage.

scholarly journals Gastrointestinal Stromal Tumor- An unusual presentation

2018 ◽  
Vol 6 (1-2) ◽  
pp. 19-22
Author(s):  
Anamika Jha ◽  
Bigyan Paudel ◽  
Akhilesh Kasyap
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Clinical Presentation ◽  
Large Mass ◽  
Stromal Tumor ◽  
Unusual Presentation ◽  
Mesenchymal Tumor ◽  
Targeted Chemotherapy ◽  
Imaging Diagnosis ◽  
Common Mesenchymal Tumor

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract which earlier was classified as leiomyomas, leiomyosarcomas and leiomyoblastomas. These are known to have specific markers and are important to diagnose as targeted chemotherapy is available. Our case represents one of the ends of the spectrum of clinical presentation of gastrointestinal tumors – an aggressive large mass at a younger than the usual age of presentation. Though challenging, imaging diagnosis of GIST is very important as it can guide the confirmation of the same by identification of the markers on pathology.

scholarly journals Gastrointestinal Stromal Tumor: A Case Report

2016 ◽  
Vol 4 (3) ◽  
pp. 120-122
Author(s):  
Stefan Krstevski
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Imaging Techniques ◽  
Specific Antigen ◽  
Complete Removal ◽  
Exploratory Laparotomy ◽  
Stromal Tumor ◽  
Large Tumor ◽  
Gold Standard Method ◽  
Reduce Mortality Rate ◽  
The Right

Background: Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal tumor but the most common mesenchymal tumor. It originates in the interstitial cells of Cajal, which on their own membranes have a specific antigen designated as CD117 or KIT receptor, a reliable indicator of tumor detection and therapy. Case: We reported a case of a 63-year-old male patient, who presented with symptoms of severe abdominal pain, discomfort, and secondary anemia. After a physical examination and a CT scan of the abdomen with angiography, the presence of a large tumor in the right hypochondrium was detected. Blood tests showed a high C-reactive protein and low hemoglobin. The patient had an exploratory laparotomy on his abdomen with complete removal of the tumor growth, which was then histologically analyzed. The obtained result from the histological analysis showed a high-degree of GIST. Conclusion: Early diagnosis of GISTs is of paramount importance to reduce mortality rate. This requires good background in pathobiology and knowledge of the physical manifestations of this malignant tumor. When this is combined with various imaging techniques, it becomes the gold standard method for GIST diagnosis.

Gastrointestinal stromal tumor – A review of clinical studies

2019 ◽  
Vol 25 (6) ◽  
pp. 1473-1485 ◽  
Author(s):  
Ardavan Khoshnood
Keyword(s):  
Overall Survival ◽  
Clinical Trials ◽  
Gastrointestinal Stromal Tumor ◽  
Survival Rates ◽  
Stromal Tumor ◽  
Tumor Patients ◽  
Third Line ◽  
New Treatments ◽  
Common Mesenchymal Tumor ◽  
Overall Survival Rates

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. With the advent of Imatinib, the treatment of gastrointestinal stromal tumor has been revolutionized as both the progression-free and overall survival rates have increased dramatically. Unfortunately, gastrointestinal stromal tumor patients on Imatinib do eventually fail due to resistance. Even though sunitinib and regorafenib have been shown to be highly effective as second- and third-line treatments, both have limited effects. New treatments are highly warranted for this reason. In this present review, 25 registered pharmacological clinical trials at ClinicalTrials.gov have been reviewed and show promising and encouraging results.

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