scholarly journals A Case Presentation of Gastrointestinal Stromal Tumor of Duodenum

2021 ◽  
Vol 5 (1) ◽  
pp. 49-53
Author(s):  
Aamir Ghazanfar ◽  
Afifa Asghar ◽  
Farrukh Zaman ◽  
Hassan Mumtaz ◽  
Shahzeb Habib ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Abdominal Distension ◽  
Stromal Tumor ◽  
Palpable Mass ◽  
Case Presentation ◽  
Complete Surgical Resection ◽  
Abdominal Examination ◽  
Duodenal Gists ◽  
The Right ◽  
Common Mesenchymal Tumor

A gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It is caused by the mutation in KIT and PDGFRα genes. It constitutes <1% of all gastrointestinal tumors. Duodenal GISTs constitute 4.5% of all GISTs. We report a 61-year-old lady, presented with generalized abdominal pain, vomiting, abdominal distension, and nausea for the last 3 years. Physical exam-ination showed a pallor and on abdominal examination, a large palpable mass was extending from the pelvis to the right upper quadrant of the abdomen. The CT scan showed a large heterogeneously echogenic mass in the abdomen and pelvis with no lymphadenopathy and distant metastasis in this region. Laparotomy showed a large globular mass extending from the pelvis to the right upper quadrant of the abdomen adherent to the wall of a third part of the duodenum. Complete surgical resection of tumor done with an intact capsule. Microscopic examination showed neoplastic spindle cells with tumor necrosis. An immunohistochemical study confirmed GIST.

scholarly journals Giant liver hemangioma in patient with ileal gastrointestinal stromal tumor

2014 ◽  
Vol 67 (1-2) ◽  
pp. 55-59
Author(s):  
Vasilije Antic ◽  
Marjan Micev ◽  
Danijela Baskic ◽  
Violeta Mladenovic
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumor ◽  
Surgical Removal ◽  
Liver Hemangioma ◽  
Palpable Mass ◽  
Gastrointestinal Malignancies ◽  
Stromal Tumors ◽  
The Right

Introduction. Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. These tumors represent more than 80% of all mesenchymal tumors found in the gastrointestinal tract, though they account for only approximately 3% of all gastrointestinal malignancies. Literature offers case reports, which describe symptomatic gastrointestinal stromal tumors and they generally represent patients with larger tumors. Case report. We present the case of a small gastrointestinal stromal tumor in a 40-year-old man, with associated giant liver hemangioma and fever, and with history of abdominal discomfort and fever. Clinical examination revealed hepatosplenomegaly, palpable mass in the right lower abdomen, and signs of neurofibromatosis type 1 (Morbus von Recklinghausen). Computed tomography revealed a giant tumor in the right lobe of the liver. Magnetic resonance showed abscess in the hemangioma of the liver. An intestinal tumor was incidentally found and excised during surgical laparotomy. An intestinal gastrointestinal stromal tumor was revealed by histopathology and confirmed by immunohistochemistry. Although a multidisciplinary team proposed surgical removal of the liver tumor mass, the surgeons decided to follow up the patient because of a high risk of new intervention. Conclusion. According to the available data, this is a very rare case of small intestinal gastrointestinal stromal tumor, with symptoms of fever and giant abscess in the liver hemangioma.

scholarly journals A Case of a Gastrointestinal Stromal Tumor Diagnosed at the Postpartum Period

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Sefa Kurt ◽  
Aras Emre Canda ◽  
Emre Karadeniz ◽  
Tugba Yavuzsen ◽  
Ozgul Sagol ◽  
...  
Keyword(s):  
High Risk ◽  
Gastrointestinal Stromal Tumor ◽  
Side Wall ◽  
Stromal Tumor ◽  
Sufficient Information ◽  
En Bloc ◽  
Jejunal Segment ◽  
Abdominal Examination ◽  
The Right

Introduction. We discuss a rare gastrointestinal stromal tumor (GIST) case detected at the 10th postpartum week and we want to pay attention to the challenges and improvements in the diagnosis, surgery, chemotherapy, and follow-up of this rare tumor accompanied with the review of the current literature. Case Presentation. A 32-year-old multiparous woman presented with abdominal swelling 10 weeks after her second vaginal birth. Abdominal examination revealed a mass starting from the pelvic level and extending to the right upper quadrant. Radiological examinations showed a solid, multiloculated, and hypervascular mass starting from the pelvis and extending to the transverse colon. En bloc mass with a 20 cm jejunal segment resection and a left pelvic side wall peritonectomy with omentectomy was performed. The pathologic examination revealed a high-risk GIST which originated from the jejunum and disseminated to the peritoneum. The patient has been given imatinib 400 mg/day since then. She did not reveal any progression during the 15-month follow-up postoperatively. Conclusion. GIST tumors are rare and there is not sufficient information in the literature regarding its management. In this patient having high risk GIST and GIST sarcomatosis we successfully treated the patient by surgery and adjuvant imatinib chemotherapy.

scholarly journals An Ulcerated Ileal Gastrointestinal Stromal Tumor Disguised as Acute Appendicitis

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Ashish Lal Shrestha ◽  
Girishma Shrestha
Keyword(s):  
Acute Appendicitis ◽  
Gastrointestinal Stromal Tumor ◽  
Iliac Fossa ◽  
Stromal Tumor ◽  
Intermittent Fever ◽  
Case Presentation ◽  
Rebound Tenderness ◽  
Ileocecal Junction ◽  
Antimesenteric Border ◽  
Abdominal Examination

Background. Gastrointestinal stromal tumor (GIST) of the ileum is not a common differential to consider in the management of acute right iliac fossa (RIF) pain and tenderness. Finding of a normal-looking appendix intraoperatively should arouse the surgeon to explore further and look for other unanticipated pathologies. We present a case, clinically diagnosed as acute appendicitis and intraoperatively found to be an ulcerated ileal GIST.Case Presentation. A 28-year-old female without previous comorbidities presented to the emergency unit with sudden pain around the umbilicus that later migrated and localized to the RIF for one day. There was associated intermittent fever and anorexia without urinary symptoms. Abdominal examination revealed guarding and rebound tenderness at RIF. Examination by 2 senior surgeons at different points of time, the same day, made a clinical diagnosis of acute appendicitis. Ultrasonogram (USG) was inconclusive. At laparotomy through Lanz incision, the appendix was found to be normal and no other pathology was identified on walking bowel up to 3 ft proximal to ileocecal junction (ICJ). Just when closure was thought of, an ulcerated lesion could be seen through the medial aspect of the incision. On further exploration, a 7 × 5 cm ulcerated lesion arising from the antimesenteric border of the ileum was noted with localized interloop hemoperitoneum and inflammatory exudates. Ileal segmental resection anastomosis was done with peritoneal toileting. The lesion was subsequently reported to be an ulcerated malignant GIST.Conclusion. The commonest cause of RIF pain with localized peritonitis is an acutely inflamed appendix. Dilemma arises when the appendix is found to look normal. Further exploration is indicted to not miss other findings.

scholarly journals Gastrointestinal stromal tumor resulting in recurrent colic in a arabian horse gelding a report of case

2020 ◽  
Vol 4 (1) ◽  
pp. 048-050
Author(s):  
Briceño Abelardo Morales ◽  
Oliva Harmon
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Body Condition Score ◽  
Vital Signs ◽  
Abdominal Ultrasound ◽  
Stromal Tumor ◽  
Normal Limits ◽  
Eosinophilic Cytoplasm ◽  
Arabian Horse ◽  
The Right ◽  
Adjacent Segments

Background: A Grey 12-year-old Arabian endurance horse gelding was referred to the SHS Veterinary Center for anorexia, mild colic of 5 days duration, and melena of 1 day duration. The owner reported recurring colic, 12 episodes of mild colic in the previous year. Methods: On admission, vital signs were within normal limits and body condition score was estimated to be 3/9. Results: Packed cell volume (PCV) was 28% [reference range (RR): 31% to 47%] and plasma total protein was 58 g/L (RR: 60 to 80 g/L). Hematochezia was observed. Abdominal ultrasound examination detected no abnormalities. Over the next 12 h, the horse experienced hematochezia and several mild episodes of colic and death. A necropsy was performed. A mass arising from the right dorsal ascending colon near the base of the cecum and extending transmurally from the colonic mucosa into the mesocolon was a 8 cm × 5 cm × 8 cm firm, homogenous, tan mass. The portion of the mass that extended into the colonic lumen was pedunculated, with an ulcerated surface. The adjacent segments of colon were markedly reddened and edematous. Histologically, the mass was comprised of large interweaving sheets of small, spindle cells with ill-defined cell borders embedded in abundant myxomatous matrix. Tumor cells contained scant eosinophilic cytoplasm and oval to elongate nuclei with finely stippled chromatin and inconspicuous nucleoli. Mitotic figures were rare (1/10) high power fields. Tumor infiltrated between the muscularis interna and the muscularis externa at the myenteric plexi. Conclusion: Gross and histologic appearance, were consistent with a diagnosis of gastrointestinal stromal tumor.

scholarly journals Sertoliform Endometrioid Carcinomas of the Right Ovary

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A785-A785
Author(s):  
Humoud Alhubail ◽  
Khaled Aljenaee ◽  
Sulaiman Hajji
Keyword(s):  
Rare Variant ◽  
Stromal Tumor ◽  
Cystic Tumor ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
Endometrioid Adenocarcinoma ◽  
Endometrioid Carcinoma ◽  
Palpable Mass ◽  
The Right ◽  
Sex Cord Stromal Tumor

Abstract Background: Endometrioid carcinomas of the ovary are a sub-type of epithelial ovarian tumors. The vast majority are malignant and invasive. On imaging, they are usually characterized as complex nonspecific solid-cystic masses and found associated with endometriosis. However, endometrioid carcinoma of ovary resembling sex cord-stromal tumor is a rare variant of endometrioid adenocarcinoma that focally looks like a sex cord-stromal tumor with sertoli, leydig, or granulosa cells. Sertoliform endometrioid carcinoma of the ovary (SEC) is one variant that bears histologic similarity to Sertoli and Sertoli-Leydig cell tumors (SLTs). Clinical Case: A 47 year old, premenopausal female, presented with rapid growing hirsutism, frontal hair loss, abdominal distension and constipation for less than one year. On clinical examination modified Ferriman-Gallwey (mFG) score was 17/36. Abdominal examination showed a palpable mass in lower abdomen, 25cm in size, rounded, and hard in nature. CT abdomen and pelvis revealed large pelvic abdominal mass (21x20.5x17 cm) with cystic and basal soft tissue components related to right ovary. Preoperatively laboratory investigations showed FSH 9.96 mIU/mL, LH 15.4, Estradiol (E2) 94.7 pg/ml, raised total testosterone 4.38 nmol/l, normal SHBG 34 nmol/l and normal DHEA-S 161 microg/dl. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was done, in which the right ovary was seen to be replaced by a solid cystic tumor with ruptured capsule. Grossly, the right ovary was enlarged measuring 9.5 cm × 8 cm × 4.8 cm. Microscopy showed round to solid tubules lined by pseudostratified columnar epithelium with elongated nuclei resembling sertoli tumor-like pattern along with conventional endometrioid tumor. A histopathological diagnosis of SEC of right ovary was made. Immunohistochemistry showed tumor cells strongly immunoreactive for epithelial membrane antigen (EMA), cytokeratin (CK) but negative for inhibin, thus confirming the diagnosis of SEC of right ovary. Conclusion: SEC is extremely rare variant of endometrioid carcinomas and tend to present at an earlier stage as compared with most endometrioid carcinomas of the ovary. Recognition of SEC in virilizing patients is important as it is a well-differentiated, low-grade malignancy that displays a good prognosis when confined to the ovary.

scholarly journals Gastrointestinal Stromal Tumor of the Tongue

2013 ◽  
Vol 28 (1) ◽  
pp. 28-33
Author(s):  
Andrie Jeremy Formanez ◽  
Grace Naomi B. Galvan-Bravo
Keyword(s):  
Tyrosine Kinase ◽  
Gastrointestinal Stromal Tumor ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Stromal Tumor ◽  
Surgical Removal ◽  
Repeat Surgery ◽  
Complete Surgical Resection ◽  
Tender Mass ◽  
Immunohistochemical Studies

Objective: To report a case of a gastrointestinal stromal tumor presenting as a recurrent tongue mass Methods: Study Design: Case Report Setting: Tertiary Public Hospital Participant: One patient Results: A 40-year-old Filipino soldier from Camarines Sur presented with a recurrent tongue mass two years after excision of a progressively-enlarging, firm, fixed, non-tender mass at the left posterior third of the tongue diagnosed as a Schwannoma. Repeat surgery involved partial glossectomy via midline mandibular swing. Final histopathologic report after immunohistochemical studies for CD117, SMA, and S100 was extraintestinal gastrointestinal stromal tumor of the tongue. The patient was started on the c-kit tyrosine kinase inhibitor Imatinib with no recurrence 10 months post treatment. Conclusion: Gastrointestinal stromal tumor may be considered when presented with a recurrent tongue mass despite complete surgical resection. Surgical removal is curative for most lesions. Post-operative chemotherapy with the use of Imatinib is valuable. Keywords: recurrent tongue mass, gastrointestinal stromal tumor, immunohistochemistry, c-kit tyrosine kinase inhibitor

scholarly journals Imaging Features of Breast Periductal Stromal Tumor: A Case Report

2021 ◽  
Vol 11 ◽  
Author(s):  
Ning Ding ◽  
Ying Jiang ◽  
Haimin Liu ◽  
Fuling Zheng ◽  
Shenling Zhu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Digital Breast Tomosynthesis ◽  
Stromal Tumor ◽  
Imaging Features ◽  
Breast Tomosynthesis ◽  
Palpable Mass ◽  
Full Field ◽  
Full Field Digital Mammography ◽  
The Right ◽  
Biphasic Tumor

Breast periductal stromal tumor (PDST) is a rare biphasic tumor, with both benign ductal epithelium and non-phyllodes sarcomatous stroma. Its imaging features were rarely reported due to the rarity. In this study, we describe the case of a 48-year-old female who presented with a palpable mass in the right breast. Presurgery imaging evaluations of full-field digital mammography (FFDM), digital breast tomosynthesis (DBT), and ultrasonography (US) were performed. The imaging features include the following: 1. multiple solid lobulated lesions comprising nearly the entire right breast; 2. hypoechoic heterogeneous masses with internal separations and abundant blood flow; 3. FFDM and DBT showed multiple irregular high-density masses with lobulated margin, partially integrated. The patient underwent extended mastectomy of the right breast. The surgical pathology confirmed a PDST. After excision of the mass, she was followed up in the outpatient clinic for 25 months without local recurrence or distant metastasis.

scholarly journals A CASE OF HIGHLY MALIGNANT GASTROINTESTINAL STROMAL TUMOR WITH METASTASIS OF THE RIGHT ADRENAL GLAND

2003 ◽  
Vol 64 (3) ◽  
pp. 657-662
Author(s):  
Hisashi IMAI ◽  
Takashi SUHARA ◽  
Yoshiyuki SASAKI ◽  
Harumi TAKAHASHI ◽  
Shigetoyo SAJI
Keyword(s):  
Adrenal Gland ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
The Right

scholarly journals Curative resection of a duodenal gastrointestinal stromal tumor in the setting of von Willebrand’s disease

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
Kyle Litow ◽  
Gaby Jabbour ◽  
Alexandra Bahn-Humphrey ◽  
Christy Stoller ◽  
Peter Rhee ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Hemorrhage ◽  
Alimentary Tract ◽  
Exploratory Laparotomy ◽  
Stromal Tumor ◽  
Von Willebrand's Disease ◽  
Von Willebrand’S Disease ◽  
Massive Gastrointestinal Hemorrhage ◽  
Emergent Laparotomy ◽  
Common Mesenchymal Tumor

Abstract Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the alimentary tract and usually presents with gastrointestinal hemorrhage. The diagnosis of GIST is typically made with upper endoscopy after excluding other causes of bleeding. The surgical management of GIST can be challenging depending upon the location of the tumor. We present a unique case of duodenal GIST in the setting von Willebrand’s disease diagnosed after emergent laparotomy for massive gastrointestinal hemorrhage. Key strategies in curing our patient were treating the underlying bleeding disorder, collaborating with radiology and gastroenterology teams, and early exploratory laparotomy for refractory hemorrhage. This case demonstrates the challenges of diagnosing and managing GIST in patients with underlying coagulopathies.

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