Pioneering work on HIV/AIDS in Uganda

2015 ◽  
Author(s):  
Peter Mugyenyi
Keyword(s):  
Antiretroviral Therapy ◽  
Health Education ◽  
Research And Development ◽  
Clinical Research ◽  
Collaborative Research ◽  
Research Centre ◽  
Hiv Aids

Chapter 4 describes how the author and his colleagues set about trying to tackle HIV/AIDS in Uganda through health education and prevention campaigns, collaborative research, and, ultimately, treatment. It covers how, through the work of the Joint Clinical Research Centre and active support from the country’s President, Uganda took the lead in many aspects of research and development, and how it became clear that the biggest challenges were securing access to treatments and confronting attitudes that the use of antiretroviral therapy (ART) in Africa was simply unfeasible. It also describes how ART became available and successful services were established throughout the country, how Uganda served as a model for many other countries in Africa, and explains the continuing need for investment and development to maintain and build on these successes.

scholarly journals Factors associated with virological non-suppression among HIV-positive children receiving antiretroviral therapy at the Joint Clinical Research Centre in Lubowa, Kampala Uganda

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246140
Author(s):  
Sarah Nabukeera ◽  
Joseph Kagaayi ◽  
Fredrick Edward Makumbi ◽  
Henry Mugerwa ◽  
Joseph K. B. Matovu
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Side Effects ◽  
Clinical Research ◽  
Clinical Stage ◽  
Research Centre ◽  
Hiv Positive ◽  
Factors Associated ◽  
Art Initiation ◽  
Stage 4

Background While the proportion of HIV-positive children (under 15 years) enrolled on antiretroviral therapy (ART) has increased in recent years, up to 60% of children started on ART do not achieve virological suppression. We set out to determine the factors associated with virological non-suppression among children living with HIV receiving ART at a peri-urban HIV care clinic in Kampala, Uganda. Method This was a retrospective cohort study conducted at the pediatric HIV/AIDS clinic at the Joint Clinical Research Centre (JCRC) in Kampala, Uganda. Three hundred (300) HIV-positive children (0–14 years) were randomly selected from existing medical records and data on children’s socio-demographic and clinical characteristics (age at ART initiation, WHO clinical staging, and ART-induced side effects) were abstracted using a data abstraction form. Virological non-suppression was defined as a viral load ≥1000 copies/Ml of blood after six months of ART initiation. Incident rate ratios (IRRs) were determined as a measure of association between virological non-suppression and child/patient characteristics. The IRRs were obtained via a modified Poisson regression with corresponding 95% confidence intervals (95%CI). All analyses were done using statistical package, Stata version 15. Results The overall non-suppression rate among HIV-positive children on ART was 23%. Being at WHO clinical stage 4 at ART initiation [adj. IRR 2.74; 95%CI: 1.63, 4.61] and ART-induced side effects [adj. IRR 1.77; 95%CI: 1.06, 2.97] were significantly associated with non-suppression. Older age at ART initiation (age 5–9 years: [adj. IRR 0.42; 95%CI: 0.28, 0.65]; age 10–14 years: [adj. IRR 0.34; 95%CI: 0.18, 0.64] was less likely to be associated with virological non-suppression. Conclusion Nearly a quarter of HIV-positive children on ART had a non-suppressed viral load after six months of treatment. Being at WHO clinical stage 4 at ART initiation and ART-induced side effects were significantly associated with virological non-suppression while older age at ART initiation was protective. Our findings suggest a need for age-specific interventions, particularly those targeting children below five years of age, to improve virological suppression among HIV-positive children receiving ART in this setting.

scholarly journals Impact of default rate of antiretroviral use on viral load among HIV/AIDS patients in Tamale and Sunyani

2021 ◽  
Vol 8 (3) ◽  
pp. 87-91
Author(s):  
James Abugri
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Hematological Parameters ◽  
Research Centre ◽  
Full Blood Count ◽  
P Value ◽  
Aids Patients ◽  
Persons Living With Hiv ◽  
Hiv Aids

Background: Highly Active Antiretroviral Therapy (HAART) for persons living with HIV/AIDS (PLWHA) is the gold standard for the management of HIV patients. Purportedly, patients who are not on HAART or defaulted from its use have adverse effects compared to those who adhere to the intake of HAART. Compliant individuals have improved quality of life and show healthy hematological parameters and HIV load as compared to HAART naïve individuals and defaulters. Supplementary and supportive treatment is crucial in HIV/AIDS patients on patients on antiretroviral therapy? Objective: This study was conducted to assess the consistency and default of HAART intake and other supportive treatments and its relationship with viral load on hematological parameters in two different geographical sites. Methods: Ethical clearance was obtained from Navrongo Health Research Centre. Questionnaires were administered to participants for their consent, demographic data, consistency of taking antiretrovirals, and types of antiretrovirals used. Full blood count and HIV load tests were carried out using Urit 5250 and Cobas Taqman / Cobas ampliprep fully automated analysers respectively. Results: Defaulters had a significant (p value=0.003) rise in their viral load (845334.38±409285.62) copies/mL in comparison to adherents in HAART intake 49571.69±30548.89) copies/mL. The hemoglobin level (10.51±0.60 g/dL) of defaulters was significantly (p-value = 0.007) lower than that of adherent (12.04±0.17 g/dL). The default rates in the two study sites were close (9.8% in Sunyani and 9.4% in Tamale). Conclusion: Antiretroviral default does not only lead to an increase in HIV load but also causes a reduction in hemoglobin levels. Hematinics supplementation therapy may help normalize hematological parameters in HIV infection

Framework for identification of performance metrics for research and development collaborations: Construction Innovation Centre

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Aminah Robinson Fayek ◽  
Alireza Golabchi
Keyword(s):  
Research And Development ◽  
Collaborative Research ◽  
Performance Metrics ◽  
Research Priorities ◽  
Research Centre ◽  
Content Type ◽  
Research Areas ◽  
Industry Research ◽  
Novel Approach ◽  
Outreach Services

PurposeThe purpose of this study is to provide a framework to identify performance metrics for evaluating research and development collaborations.Design/methodology/approachThe framework is developed through a review of similar centres and academic studies, followed by surveys and interviews of researchers and industry practitioners for the case of the Construction Innovation Centre (CIC). The proposed framework consists of identification of existing industry research and development needs, development of a research roadmap representing top research priorities, and identification of the most important services to provide to industry partners, which form the context for defining performance evaluation metrics.FindingsA research roadmap is presented, outlining top research areas and methods and a list of the most in-demand services including research, practical and training and outreach services. Metrics for evaluating the performance of proposed projects, completed projects and a collaborative research centre are also identified.Originality/valueThis study presents a novel approach to defining performance metrics for the evaluation of research and development collaborations. The approach and findings of this study can be adopted by other collaborative research centres and initiatives around the world to develop effective metrics for performance measurement. The proposed framework provides a platform for defining performance metrics in the context of the research roadmap and top-priority services applicable to the research and development collaboration.

The “Worried Well” Among Clients Attending HIV/AIDS Counselling and Testing Services at a Clinical Research Centre in SW Uganda

2014 ◽  
Vol 30 (S1) ◽  
pp. A113-A114 ◽  
Author(s):  
Richard Rwanyonga ◽  
Andrew Abaasa ◽  
Gershim Asiki ◽  
Benjamin Twefeho ◽  
Ubaldo Bahemuka ◽  
...  
Keyword(s):  
Clinical Research ◽  
Research Centre ◽  
Hiv Aids

Operation Teddy

2003 ◽  
Vol 1 (1) ◽  
pp. 20-28
Author(s):  
Lyndall Ellingson
Keyword(s):  
Health Education ◽  
Service Learning ◽  
Hiv Infection ◽  
Aids Prevention ◽  
Education Curriculum ◽  
Infection Rates ◽  
Community Members ◽  
Education Students ◽  
Prevention Education ◽  
Hiv Aids

Current adolescent HIV infection rates support the need for early HIV/AIDS prevention education. This article describes a successful service-learning project in which undergraduate health education students developed and taught an elementaryschool HIV/AIDS prevention education curriculum that included a compassion component involving donation of teddy bears to community members affected with HIV/AIDS.

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