Haemolytic uraemic syndrome

Cell Activation ◽

Microangiopathic Haemolytic Anaemia

The haemolytic uraemic syndrome (HUS) is characterized by the triad of: (1) microangiopathic haemolytic anaemia, (2) thrombocytopenia, and (3) acute renal failure. Endothelial cell activation leads to a change in phenotype from an anticoagulant to a procoagulant state. Diarrhoeal associated (D+) HUS—this accounts for over 90% of cases and is the commonest cause of acute renal failure in children. The usual pathogen is enterohaemorrhagic ...

Microangiopathic Haemolytic Anaemia before and after Renal Transplantation

Scottish Medical Journal ◽

10.1177/003693308002500417 ◽

1980 ◽

Vol 25 (4) ◽

pp. 323-326

Author(s):

Catriona Williams ◽

J. L. Anderton ◽

P. A. Yates

Keyword(s):

Renal Failure ◽

Renal Transplantation ◽

Chronic Renal Failure ◽

Haemolytic Anaemia ◽

Pulmonary Haemorrhage ◽

Microangiopathic Haemolytic Anaemia ◽

Before And After ◽

Life Threatening ◽

Transplant Nephrectomy

A patient who developed chronic renal failure secondary to the haemolytic uraemic syndrome subsequently developed life threatening microangiopathic haemolytic anaemia following renal transplantation. Transplant nephrectomy was necessary to prevent the progression ofthrombocytopenia and associated pulmonary haemorrhage.

Markers of endothelial cell activation and injury in childhood haemolytic uraemic syndrome

Pediatric Nephrology ◽

10.1007/s004670050644 ◽

1999 ◽

Vol 13 (6) ◽

pp. 487-492 ◽

Cited By ~ 15

Author(s):

Corinne H. F. Nevard ◽

Andrew D. Blann ◽

Karen M. Jurd ◽

George B. Haycock ◽

B. J. Hunt

Keyword(s):

Endothelial Cell ◽

Cell Activation ◽

Adiponectin Is Related to CD146, a Novel Marker of Endothelial Cell Activation/Injury in Chronic Renal Failure and Peritoneally Dialyzed Patients

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2004-0387 ◽

2004 ◽

Vol 89 (9) ◽

pp. 4620-4627 ◽

Cited By ~ 40

Author(s):

Jolanta Malyszko ◽

Jacek S. Malyszko ◽

Szymon Brzosko ◽

Slawomir Wolczynski ◽

Michal Mysliwiec

Keyword(s):

Renal Failure ◽

Endothelial Cell ◽

Chronic Renal Failure ◽

Cell Activation ◽

Severe Haemolytic Anaemia Resulting from a Malpositioned Haemodialysis Catheter

European Journal of Case Reports in Internal Medicine ◽

10.12890/2021_002789 ◽

2021 ◽

Author(s):

Mohammad Ammad Ud Din ◽

Hania Liaqat ◽

Prabhsimrat Gill ◽

Soon Khai Low

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Thrombotic Thrombocytopenic Purpura ◽

Haemolytic Anaemia ◽

Rare Complication ◽

Differential Diagnoses ◽

Thrombocytopenic Purpura ◽

Haemodialysis Catheter

Severe haemolytic anaemia is a rare complication of haemodialysis that is often difficult to recognize, especially when there are other potential differential diagnoses. Here, we present the case of 19-year-old man on haemodialysis who developed severe haemolytic anaemia while recovering from acute renal failure secondary to rhabdomyolysis. Other causes of haemolytic anaemia such as thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome were ruled out. As his blood counts were dropping on days following haemodialysis, haemolysis secondary to the mechanical sheering effect of the catheter was considered and his haemodialysis catheter was exchanged, which led to the resolution of anaemia.

Adhesion molecule expression and endothelial cell activation in cutaneous leukocytoclastic vasculitis. An immunohistologic and clinical study in 42 patients

Archives of Dermatology ◽

10.1001/archderm.133.4.443 ◽

1997 ◽

Vol 133 (4) ◽

pp. 443-450 ◽

Cited By ~ 10

Author(s):

G. Sais

Keyword(s):

Endothelial Cell ◽

Clinical Study ◽

Adhesion Molecule ◽

Cell Activation ◽

Leukocytoclastic Vasculitis ◽

Adhesion Molecule Expression ◽

Faculty Opinions recommendation of Loss of DGKε induces endothelial cell activation and death independently of complement activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725276451.793502628 ◽

2014 ◽

Author(s):

Toshiyuki Miyata

Keyword(s):

Endothelial Cell ◽

Complement Activation ◽

Cell Activation ◽

Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0007656 ◽

2020 ◽

Vol 14 (7) ◽

pp. e0007656

Author(s):

João Conrado Khouri Dos-Santos ◽

João Luiz Silva-Filho ◽

Carla C. Judice ◽

Ana Carolina Andrade Vitor Kayano ◽

Júlio Aliberti ◽

...

Keyword(s):

Endothelial Cell ◽

Plasmodium Vivax ◽

Vivax Malaria ◽

Cell Activation ◽

Plasmodium Vivax Malaria

Signs of sympathetic and endothelial cell activation in the skin of patients with restless legs syndrome

Sleep Medicine ◽

10.1016/j.sleep.2021.05.044 ◽

2021 ◽

Author(s):

Melanie Bergmann ◽

Anna Heidbreder ◽

Ambra Stefani ◽

Cecilia Raccagni ◽

Elisabeth Brandauer ◽

...

Keyword(s):

Endothelial Cell ◽

Restless Legs Syndrome ◽

Cell Activation ◽

Restless Legs

OR17 Heme oxygenase-1 modulates HLA class I antibody-dependent endothelial cell activation

Human Immunology ◽

10.1016/j.humimm.2015.07.023 ◽

2015 ◽

Vol 76 ◽

pp. 15

Author(s):

Eva Zilian ◽

Hendry Saragih ◽

Oliver Hiller ◽

Abid Aljabri ◽

Constanca Figueiredo ◽

...

Keyword(s):

Endothelial Cell ◽

Heme Oxygenase ◽

Cell Activation ◽

Hla Class I ◽

Class I ◽

Heme Oxygenase 1 ◽

Dengue Virus Induces the Expression and Release of Endocan from Endothelial Cells by an NS1–TLR4-Dependent Mechanism

Microorganisms ◽

10.3390/microorganisms9061305 ◽

2021 ◽

Vol 9 (6) ◽

pp. 1305

Author(s):

Carlos Alonso Domínguez-Alemán ◽

Luis Alberto Sánchez-Vargas ◽

Karina Guadalupe Hernández-Flores ◽

Andrea Isabel Torres-Zugaide ◽

Arturo Reyes-Sandoval ◽

...

Keyword(s):

Endothelial Cell ◽

Mrna Expression ◽

Cell Lines ◽

Cell Activation ◽

Dengue Infection ◽

Elevated Serum ◽

Fold Increase ◽

Stimulation Of

A common hallmark of dengue infections is the dysfunction of the vascular endothelium induced by different biological mechanisms. In this paper, we studied the role of recombinant NS1 proteins representing the four dengue serotypes, and their role in promoting the expression and release of endocan, which is a highly specific biomarker of endothelial cell activation. We evaluated mRNA expression and the levels of endocan protein in vitro following the stimulation of HUVEC and HMEC-1 cell lines with recombinant NS1 proteins. NS1 proteins increase endocan mRNA expression 48 h post-activation in both endothelial cell lines. Endocan mRNA expression levels were higher in HUVEC and HMEC-1 cells stimulated with NS1 proteins than in non-stimulated cells (p < 0.05). A two-fold to three-fold increase in endocan protein release was observed after the stimulation of HUVECs or HMEC-1 cells with NS1 proteins compared with that in non-stimulated cells (p < 0.05). The blockade of Toll-like receptor 4 (TLR-4) signaling on HMEC-1 cells with an antagonistic antibody prevented NS1-dependent endocan production. Dengue-infected patients showed elevated serum endocan levels (≥30 ng/mL) during early dengue infection. High endocan serum levels were associated with laboratory abnormalities, such as lymphopenia and thrombocytopenia, and are associated with the presence of NS1 in the serum.