Disorders of the neuromuscular junction
2010 ◽
pp. 5177-5184
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Keyword(s):
Two fundamentally different pathological processes are associated with disease at the neuromuscular junction: (1) acquired disorders in which autoantibodies are directed against nerve or muscle receptor or ion channels; (2) rare inherited conditions in which the defect may be pre- or postsynaptic. Aetiology and epidemiology—the fundamental disorder is loss of functional acetylcholine receptors most frequently as a result of binding of anti-acetylcholine receptor (anti-AChR) antibodies. Incidence is about 10 per million population and prevalence about 8 per 100 000, with a marked female bias in cases aged under 40 years and male preponderance in those over 50 years. Thymomas occur in about 10% of cases....
2022 ◽
Keyword(s):
1985 ◽
Vol 5
(3)
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pp. 751-758
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1991 ◽
Vol 39
(5)
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pp. 625-634
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1991 ◽
Vol 331
(1261)
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pp. 273-280
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1998 ◽
Vol 111
(17)
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pp. 2595-2605
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1987 ◽
Vol 132
(1)
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pp. 223-230
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2015 ◽
Vol 26
(5)
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pp. 938-951
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