Normal hepatic function

2018 ◽  
Author(s):  
Satish Keshav ◽  
Palak Trivedi
Keyword(s):  
Liver Function ◽  
Liver Dysfunction ◽  
Functional Anatomy ◽  
Normal Liver ◽  
Hepatic Function ◽  
Lymphatic Drainage ◽  
Normal Liver Function ◽  
Biliary Anatomy ◽  
Liver Anatomy ◽  
Normal Hepatic Function

This chapter explores normal liver function, including liver anatomy (vasculature, biliary anatomy, lymphatic drainage, innervation of the liver, and functional anatomy of the liver), basic physiology, and mechanisms of liver dysfunction.

scholarly journals Effects of grade B liver dysfunction on the level of free hexafluoroisopropanol of sevoflurane metabolites in patients with abdominal surgery

2020 ◽  
Author(s):  
Xiao-lin Yang ◽  
Ming Li ◽  
Yan Feng ◽  
Guo-Yuan Zhang
Keyword(s):  
Liver Function ◽  
Liver Dysfunction ◽  
Normal Liver ◽  
Time Orientation ◽  
Peak Time ◽  
Normal Liver Function ◽  
Time Points ◽  
Extubation Time ◽  
Group A ◽  
Group B

Abstract Background: Study shows the metabolite, hexafluoroisopropanol (HFIP) from sevoflurane, has a strong inhibition on the central nervous system. This study aims to compare the level of free HFIP in the blood after inhaled a same concentration of sevoflurane in patients with normal liver function versus grade B liver dysfunction and observe its effect on patients’ recovery quality.Methods: Twenty four patients with normal liver function and twenty four patients with grade B liver dysfunction undergoing elective abdominal surgery were selected and assigned to group A and group B, respectively. All patients were inhaled sevoflurane (1.5MAC) for anesthesia about 3 h. The free HFIP concentration was determined at the time points of 0.5 h, 1 h, 2 h, 3 h after inhaled sevoflurane and 0.5 h, 1 h, 2 h, 4 h after discontinuation of sevoflurane, respectively. Patients’ eyes opening time, orientation recovery time, command response time and extubation time were observed after operation. The visual analogue scale (VAS) and Ramsay sedation score (RSS) were also evaluated at different time points after extubation. Results: Although the peak time of free HFIP in group B was 1 h later than that in group A, no significant differences were found in the peak concentration and other corresponding time points’ free HFIP concentrations between the two groups (P<0.05). All the eyes opening time, orientation recovery time, command response time and extubation time in group B were longer than those in group A (P<0.05). Compared to group A, a lower VAS score and a higher RSS score were found in group B at 0 min, 15 min, 30 min,1 h, 2 h and 3 h after extubation, respectively (P<0.05). Conclusion: The status of patients with grade B liver dysfunction does not affect the degree of sevoflurane metabolism. However, it can significantly prolong the peak time of free HFIP when compared with normal liver function.Trial registry number: Identified as ChiCTR 2000028901at http://www.chictr.org.cn/

scholarly journals The Pattern of Liver Dysfunction in Patients with COVID-19: A Retrospective Study

2020 ◽  
Author(s):  
Chunyan wang ◽  
Yihui Rong ◽  
Lei Wei ◽  
Huanwei Zheng ◽  
Jing Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Liver Function ◽  
Liver Dysfunction ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Viral Shedding ◽  
Type 3

Abstract Background. Information about liver dysfunction in patients with COVID-19 is scarce. We aimed to explored the pattern and risk factors of liver dysfunction in patients with COVID-19.Methods. In this retrospective study, we included all consecutive confirmed patients with COVID-19 in Fuyang Second People’s Hospital between January 20 and February 25, 2020 and collected clinical characteristics until discharge. The pattern and risk factors of liver dysfunction, viral shedding and outcome were analyzed.Results. Totally, 146 patients were analyzed. The median age was 44.9 years and 54.1% were men, 43.8% patients presented liver dysfunction (22.6% on admission, 21.2% during hospitalization). The percentage of elevated ALT (15.1% on admission and 24.7% during hospitalization) were significantly higher than ALP (2.1% on admission and 3.4% during hospitalization) (P < 0.001). Four clinical types were identified, type 1 (persistent normal liver function, 56.2%), type 2 (normal liver function on admission developed to liver dysfunction during hospitalization, 21.2%), type 3 (liver dysfunction on admission restored to normal on discharge, 13.0%) and type 4 (persistent liver dysfunction, 9.6%). The median duration of viral shedding was 12.0 (type 1), 15.0 (type 2), 14.0 (type 3) and 18.0 (type 4) days (P < 0.001). Prolonged viral shedding and severity were potential risk factors associated with liver dysfunction. Conclusions. The incidence of liver dysfunction in patients with COVID-19 is common but not severe, which mainly due to SARS-CoV-2-mediated immune injury on hepatocyte rather than cholangiocyte, DILI and underlying chronic liver disease should not be neglect.

Management of Obscurely Dilated Common Bile Duct with Normal Liver Function Tests: A Pragmatic Approach

2021 ◽  
Author(s):  
Sundeep Singh Saluja ◽  
Vaibhav Kumar Varshney ◽  
Vidya Sharada Bhat ◽  
Phani Kumar Nekarakanti ◽  
Asit Arora ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Pragmatic Approach ◽  
Normal Liver Function ◽  
Function Tests

Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic

Diagnosis ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Wycliffe Mbagaya ◽  
Joanne Foo ◽  
Ahai Luvai ◽  
Claire King ◽  
Sarah Mapplebeck ◽  
...  
Keyword(s):  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Normal Liver ◽  
Abdominal Ultrasound ◽  
Liver Function Tests ◽  
Analytical Investigation ◽  
Normal Liver Function ◽  
Rheumatology Clinic ◽  
History Of ◽  
Liver Biopsies

AbstractMacrocomplexes between immunoglobins and aspartate aminotransferase (macro-AST) may result in persistently increased AST concentration. The presence of macro-AST in patients has been implicated in unnecessary investigations of abnormal liver function tests. We report the case of a 44-year-old female who presented to the rheumatology clinic with a 12-months’ history of constant widespread pain affecting her limbs and was found to have an elevated AST concentration. Further information from her GP revealed a 14-years’ history of elevated AST with otherwise normal liver function. Previous abdominal ultrasound and two liver biopsies carried out 2 years apart were normal. This prompted further analytical investigation by the biochemistry department which identified macro-AST as the cause. This case illustrates that persistently raised isolated AST concentration with no other abnormal indices may warrant macroenzyme analysis potentially avoiding unnecessary invasive investigations.

scholarly journals Mildly elevated succinylacetone and normal liver function in compound heterozygotes with pathogenic and pseudodeficient FAH alleles

2018 ◽  
Vol 14 ◽  
pp. 55-58 ◽  
Author(s):  
Hao Yang ◽  
Francis Rossignol ◽  
Denis Cyr ◽  
Rachel Laframboise ◽  
Shu Pei Wang ◽  
...  
Keyword(s):  
Liver Function ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Compound Heterozygotes

Case 1.4

2014 ◽  
pp. 7-8
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Liver Function ◽  
Neutrophil Count ◽  
Laboratory Tests ◽  
Normal Liver ◽  
Normal Liver Function ◽  
Nonproductive Cough

67-year-old woman status post fundoplication 2 months ago, with development of fever and nonproductive cough shortly afterward; laboratory tests revealed normal liver function and an increased neutrophil count Coronal SSFSE image (Figure 1.4.1) and axial fat-suppressed T2-weighted FSE image (Figure 1.4.2...

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