Drugs used in rheumatology

2011 ◽  
pp. 545-588
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Pulmonary Hypertension ◽  
Pain Relief ◽  
Opioid Analgesics ◽  
Biologic Therapies ◽  
Inflammatory Drugs ◽  
Disease Modifying ◽  
Anti Inflammatory

Introduction 546 Principles of rehabilitation 548 Pain relief 550 Opioid analgesics 554 Non-steroidal anti-inflammatory drugs 556 Antidepressants 560 Anticonvulsants 562 Glucocorticoids 564 (Non-biologic) disease-modifying anti-rheumatic drugs 566 Biologic therapies 580 Other medication 586 Drugs used in the management of hyperuricaemia, pulmonary hypertension, and osteoporosis are discussed in ...

scholarly journals Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Rebecca S. Y. Wong
Keyword(s):  
Pain Relief ◽  
Adverse Effects ◽  
Musculoskeletal System ◽  
First Line ◽  
Disease Research ◽  
Inflammatory Drugs ◽  
Disease Modifying ◽  
Anti Inflammatory ◽  
Continuous Use

Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.

scholarly journals Glucocorticoids for treating paediatric pulmonary hypertension: a novel use for a common medication

2017 ◽  
Vol 27 (7) ◽  
pp. 1410-1412 ◽  
Author(s):  
Manish Aggarwal ◽  
Ronald Mark Grady
Keyword(s):  
Pulmonary Hypertension ◽  
Potential Utility ◽  
Inflammatory Drugs ◽  
Laboratory Investigations ◽  
Anti Inflammatory

AbstractLaboratory investigations have shown the role of inflammation in the pathogenesis of pulmonary hypertension and improvement after anti-inflammatory drugs. Despite these observations, reports on the use of steroids to treat pulmonary hypertension in humans are absent from the literature. In this article, we report the use of glucocorticoids in the treatment of two children with pulmonary hypertension, demonstrating its potential utility.

scholarly journals Comparative analysis of different methods of anesthesia in patients with acute pancreatitis using pain scales

2016 ◽  
Vol 97 (2) ◽  
pp. 217-221
Author(s):  
V N Shilenok ◽  
E V Nikitina
Keyword(s):  
Acute Pancreatitis ◽  
Comparative Analysis ◽  
Visual Analogue Scale ◽  
Pain Intensity ◽  
Epidural Anesthesia ◽  
Analogue Scale ◽  
Pain Syndrome ◽  
Opioid Analgesics ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Aim. To conduct a comparative analysis of used anesthesia methods in patients with acute pancreatitis in intensive care units settings using pain scales.Methods. Depending on the anesthesia type, 44 patients with acute pancreatitis were divided into three groups: the first group received intramuscular injections of nonsteroidal anti-inflammatory drugs and spasmolytics, the second group - intramuscular injections of non-steroidal anti-inflammatory drugs and opioid analgesics, the third group - epidural anesthesia with local anesthetics. Comparative analysis of pain character, intensity was conducted, its dynamics in patients of all groups amid anesthesia was evaluated using a visual analogue scale, verbal rating scale, verbal descriptor scale, McGill pain questionnaire.Results. Baseline pain intensity in patients of all groups was high. Patients estimated this pain as «very strong». The time and the level of pain intensity reduction for various anesthesia types had differences. Pain syndrome was eliminated slower in patients of the second group. By the end of the 1st day, patients of this group continued to complain of «strong» pain. Pain intensity decreased only on the 2nd day - patients reported «moderate» pain. Pain syndrome was not completely eliminated in these patients for 2 days of anesthesia. 97.7% of patients reported that the visual analogue scale is the most acceptable pain assessment scale for them.Conclusion. In patients with acute pancreatitis, the most optimal anesthesia types are intramuscular nonsteroidal anti-inflammatory drugs with spasmolytics and prolonged epidural anesthesia with local anesthetics; intramuscular administration of opioid analgesics with non-steroidal anti-inflammatory drugs is less effective in relieving pain.

Comparison of piroxicam and naproxen in osteoarthritis of the foot

1994 ◽  
Vol 84 (7) ◽  
pp. 348-354 ◽  
Author(s):  
MB Jennings
Keyword(s):  
Pain Relief ◽  
Joint Disease ◽  
Parallel Study ◽  
Double Blind ◽  
Significant Pain ◽  
The Us ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Osteoarthritis is the most common joint disease and the second highest ranking cause of disability in the US. Osteoarthritis commonly affects the hands, wrists, spine, knees, and feet. One of the mainstays of treatment for osteoarthritis is the use of nonsteroidal anti-inflammatory drugs. While there have been controlled comparison studies of the various nonsteroidal anti-inflammatory drugs, these have been limited to osteoarthritis of the hands, spine, and hip. This study was a randomized, double-blind, parallel study of 8 weeks' duration comparing piroxicam (Feldene, 20 mg daily) to naproxen (Naprosyn, 1,000 mg daily) in the treatment of osteoarthritis of the foot in 45 patients. Both groups experienced significant pain relief and improvement of mobility.

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