scholarly journals Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Rebecca S. Y. Wong
Keyword(s):  
Pain Relief ◽  
Adverse Effects ◽  
Musculoskeletal System ◽  
First Line ◽  
Disease Research ◽  
Inflammatory Drugs ◽  
Disease Modifying ◽  
Anti Inflammatory ◽  
Continuous Use

Spondyloarthritis or spondyloarthropathy (SpA) is a group of related rheumatic disorders, which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA. For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used as the first-line drugs to treat the disease. Research has shown that other than pain relief, NSAIDs have disease-modifying effects in SpA. However, to achieve these effects, continuous and/or long-term NSAID use is usually required. This review will give an overview of SpA, discuss NSAIDs and their disease-modifying effects in SpA, and highlight some of the important adverse effects of long-term and continuous NSAID use, particularly those related to the gastrointestinal, renal, and cardiovascular systems.

Musculoskeletal system

2011 ◽  
pp. 411-414
Author(s):  
Dr Mark Harrison
Keyword(s):  
Musculoskeletal System ◽  
Early Mobilization ◽  
Musculoskeletal Injuries ◽  
Pharmacological Intervention ◽  
Term Outcome ◽  
Long Term Outcome ◽  
System P ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

8.1 Nonpharmacological measures, 412 8.2 Nonsteroidal anti-inflammatory drugs (NSAIDs), 412 8.3 Corticosteroids, 414 8.4 Drugs used in gout and hyperuricaemia, 414 • Management of musculoskeletal injuries and diseases involves more than just pharmacological intervention. • Consideration of splinting, physiotherapy, and early mobilization can be the most effective way to ease pain and improve long-term outcome....

Treatment: NSAIDs

2016 ◽  
Author(s):  
Jonathan Chan ◽  
Nigil Haroon
Keyword(s):  
Symptom Control ◽  
Pharmacological Therapy ◽  
First Line ◽  
Safety Concerns ◽  
Randomized Controlled ◽  
Equivalent Effect ◽  
Inhibit Prostaglandin Synthesis ◽  
Inflammatory Drugs ◽  
Disease Modifying

Non-steroidal anti-inflammatory drugs (NSAIDs) constitute a diverse group of medications that inhibit prostaglandin synthesis. NSAIDs form the first-line pharmacological therapy in ankylosing spondylitis (AS). A number of randomized controlled trials (RCTs) support the efficacy of NSAIDs in reducing pain and improving patient function. Head-to-head comparisons have demonstrated equivalent effect of different NSAIDs in symptom control. The proposed disease-modifying potential of regular NSAID therapy is debatable and recent literature provides evidence to the contrary. Several safety concerns have been raised regarding long-term use of NSAIDs, especially an increase in cardiovascular risk. This chapter discusses the pharmacology, efficacy in treatment of AS, disease-modifying potential, and safety concerns of NSAIDs.

scholarly journals The Comparative Efficacy and Safety of Long- and Short-Term Continuous Use of Non-Steroidal Anti-Inflammatory Drugs for the Treatment of Knee Osteoarthritis

2020 ◽  
Vol 26 (2) ◽  
pp. 120-127
Author(s):  
B. V. Zavodovskiy ◽  
E. V. Papichev ◽  
L. E. Sivordova ◽  
Yu. V. Polyakova ◽  
Yu. R. Akhverdyan
Keyword(s):  
Knee Osteoarthritis ◽  
Pain Syndrome ◽  
Pain Level ◽  
Short Term ◽  
On Demand ◽  
Average Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Continuous Use

Objective. To compare the efficacy and tolerability of long-term and short-term continuous NSAIDs in patients with knee osteoarthritis with insufficient efficacy “on demand” NSAIDs and SYSADOA.Study design. 12-week, prospective, comparative, randomized, single-center study.Materials and Methods. 180 patients with primary knee osteoarthritis aged 40 to 85 years with insufficient efficacy of “on demand” NSAIDs and SYSADOA were examined. Anti-inflammatory drugs were recommended for everyone: 56 people took Naproxen (31.11%), 63 — Etoricoxib (35%), 61 — Ketoprofen (33.89%). Patients were randomized into two groups: 1st group — with 8-week continuous intake of NSAIDs, 2nd group — with a 2-week continuous course of NSAIDs.Results. There was a positive dynamics of pain syndrome according to VAS and decrease in the level of the WOMAC index in both groups after 2 weeks of therapy. The pain level (VAS) and WOMAC indices in 1st group achieved after 8 weeks significantly differed from the ones after 2 weeks of therapy (VAS dynamics —10.93±2.43 mm, t = 42.64; p<0.001). In both groups we noted gradual significant increase in the average pain level according to VAS and WOMAC indices after NSAIDs cancellation. However, there was better control of pain in 1st group with long-term NSAID than in 2nd one. Safety profile of drug therapy was similar in both groups.Conclusion. The long-term 8-week use of NSAIDs in patients with knee osteoarthritis with insufficient efficacy “on demand” NSAIDs and SYSADOA provides better dynamics of the pain syndrome than with 2-week therapy. After treatment is canceled longer prior NSAID therapy contributes to better control of the pain syndrome. Continuous use of NSAIDs demonstrated good tolerance and safety, did not require dose reduction and/or discontinuation of therapy. Thus, anti-inflammatory therapy of osteoarthritis in this group of patients may be prescribed for a longer period with continuous use of NSAIDs.

Prolonged Cholestatic Jaundice Associated With Flurbiprofen

2013 ◽  
Vol 27 (4) ◽  
pp. 396-398 ◽  
Author(s):  
Serkan Dogan ◽  
Mehmet Celikbilek ◽  
Kutay Demirkan ◽  
Semih Yilmaz ◽  
Kemal Deniz ◽  
...  
Keyword(s):  
Pain Relief ◽  
Adverse Effects ◽  
Cholestatic Jaundice ◽  
The World ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed drugs throughout the world for pain relief. Although the adverse effects of NSAIDs to the liver are well known, flurbiprofen-induced liver cholestasis is extremely rare. Herein, we present a patient with prolonged icterus that is associated with the use of flurbiprofen without causing ductopenia.

Drugs used in rheumatology

2011 ◽  
pp. 545-588
Author(s):  
Alan J. Hakim ◽  
Gavin P.R. Clunie ◽  
Inam Haq
Keyword(s):  
Pulmonary Hypertension ◽  
Pain Relief ◽  
Opioid Analgesics ◽  
Biologic Therapies ◽  
Inflammatory Drugs ◽  
Disease Modifying ◽  
Anti Inflammatory

Introduction 546 Principles of rehabilitation 548 Pain relief 550 Opioid analgesics 554 Non-steroidal anti-inflammatory drugs 556 Antidepressants 560 Anticonvulsants 562 Glucocorticoids 564 (Non-biologic) disease-modifying anti-rheumatic drugs 566 Biologic therapies 580 Other medication 586 Drugs used in the management of hyperuricaemia, pulmonary hypertension, and osteoporosis are discussed in ...

Orthotic therapy in the management of osteoarthritis

1992 ◽  
Vol 82 (3) ◽  
pp. 136-139 ◽  
Author(s):  
JA Thompson ◽  
MB Jennings ◽  
W Hodge
Keyword(s):  
Drug Therapy ◽  
Pain Relief ◽  
Foot And Ankle ◽  
Inflammatory Drug ◽  
Treatment Regimens ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Term Management

The authors evaluate the use of orthoses as a primary therapeutic means in the long-term management of patients with osteoarthritis of the foot and ankle. A comparison of the amount of pain relief experienced by 64 subjects (mean age 63 years) with different treatment regimens for osteoarthritis was made to determine the role orthoses played in helping to reduce or eliminate pain. One hundred percent of the subjects wearing orthoses only for relief of pain had a statistically significant longer period of pain relief than those on nonsteroidal anti-inflammatory drugs. Fifty-five percent of the subjects using orthoses and nonsteroidal anti-inflammatory drug therapy also had a statistically significant longer period of pain relief than those receiving nonsteroidal anti-inflammatory drug therapy only.

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