Community-acquired pneumonia and acute kidney injury

2018 ◽  
Author(s):  
Norbert Lameire
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Organ Dysfunction ◽  
Kidney Injury ◽  
Community Acquired Pneumonia

It is known that in one-half of the patients hospitalized for community-acquired pneumonia, severe sepsis develops, with non-pulmonary organ dysfunction developing in more than one-third and septic shock in 4.5%. Some years ago, it was found that acute kidney injury was common in community-acquired pneumonia even in patients who appeared to have an uncomplicated course of community-acquired pneumonia and where acute kidney injury was observed in one-quarter of them.

Positive fluid balance as a prognostic factor for mortality and acute kidney injury in severe sepsis and septic shock

2015 ◽  
Vol 30 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Fernando Saes Vilaça de Oliveira ◽  
Flavio Geraldo Resende Freitas ◽  
Elaine Maria Ferreira ◽  
Isac de Castro ◽  
Antonio Toneti Bafi ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Prognostic Factor ◽  
Fluid Balance ◽  
Kidney Injury ◽  
Positive Fluid Balance ◽  
Sepsis And Septic Shock

scholarly journals MP265OBESITY, ACUTE KIDNEY INJURY AND MORTALITY IN PATIENTS WITH SEVERE SEPSIS OR SEPTIC SHOCK: A COHORT ANALYSIS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii524-iii524
Author(s):  
Joana Gameiro ◽  
Marta Pereira ◽  
Natacha Rodrigues ◽  
Iolanda Godinho ◽  
Marta Neves ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Cohort Analysis ◽  
Kidney Injury

A Comparison of Acute Kidney Injury Classifications in Patients With Severe Sepsis and Septic Shock

2012 ◽  
Vol 344 (5) ◽  
pp. 350-356 ◽  
Author(s):  
Jin Won Huh ◽  
Chae-Man Lim ◽  
Younsuck Koh ◽  
Sang-Bum Hong ◽  
Won Young Kim
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Kidney Injury ◽  
Sepsis And Septic Shock

scholarly journals Acute Kidney Injury in Severe Sepsis and Septic Shock in Patients with and without Diabetes Mellitus: A Multicenter Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0127411 ◽  
Author(s):  
Marion Venot ◽  
Lise Weis ◽  
Christophe Clec’h ◽  
Michael Darmon ◽  
Bernard Allaouchiche ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Multicenter Study ◽  
Kidney Injury ◽  
Sepsis And Septic Shock

Association between left ventricular diastolic dysfunction and septic acute kidney injury in severe sepsis and septic shock: A multicenter retrospective study

Perfusion ◽  
2021 ◽  
pp. 026765912198896
Author(s):  
Guangwei Yu ◽  
Kun Cheng ◽  
Qing Liu ◽  
Xiaohong Lin ◽  
Fenghui Lin ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Retrospective Study ◽  
Kidney Injury ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Septic Acute Kidney Injury ◽  
Ventricular Diastolic Dysfunction ◽  
Sepsis And Septic Shock

Introduction: Left ventricular diastolic dysfunction (LVDD) adversely impacts renal function, and E/e′ is a significant predictor of adverse kidney events under different clinical conditions. However, no studies have evaluated the association between LVDD and septic acute kidney injury (AKI) among patients with severe sepsis and septic shock. Methods: This multicenter retrospective study evaluated adult patients with severe sepsis or septic shock between January 1, 2013, and December 31, 2019, who underwent echocardiography within 24 hours after admission to an intensive care unit. Results: A total of 495 adult patients were enrolled in the study. LVDD grades II and III were associated with severe (stage 3) AKI ( p < 0.001, p for trend < 0.001). E/e′ and e′ were risk factors for septic AKI (OR, 1.155; 95% CI, 1.088–1.226, p < 0.001; and OR, 7.218; 95% CI, 2.942–17.712, p < 0.001, respectively) in the multivariate logistic regression analysis. The area under the receiver operating characteristic curve of E/e′ and e′ was 0.728 (95% CI, 0.680–0.777, p < 0.001) and 0.715 (95% CI, 0.665–0.764, p < 0.001), respectively. Conclusions: LVDD was associated with septic AKI, and E/e′ and e′ are useful predictors of septic AKI among patients with severe sepsis or septic shock. Trial registration The study was registered at the Chinese Clinical Trial Registry (Protocol No. ChiCTR2000033083).

Blood Product Transfusion And Acute Kidney Injury In Severe Sepsis, Septic Shock Patients

2012 ◽  
Author(s):  
Insara Jaffer Sathick ◽  
Rahul Kashyap ◽  
Juan Valerio-Rojas ◽  
Anil Paturi ◽  
Kianoush Kashani ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Severe Sepsis ◽  
Blood Product ◽  
Kidney Injury ◽  
Blood Product Transfusion

Association Between Unbalanced Solutions and Acute Kidney Injury During Fluid Resuscitation in Children With Sepsis

2021 ◽  
pp. 088506662110044
Author(s):  
Jaime Fernández-Sarmiento ◽  
Catalina Alcalá-Lozano ◽  
Pedro Alexander Barrera ◽  
Sofía Camila Erazo Vargas ◽  
Laura Bibiana Gómez Cortes ◽  
...  
Keyword(s):  
Septic Shock ◽  
Acute Kidney Injury ◽  
Metabolic Acidosis ◽  
Propensity Score ◽  
Organ Dysfunction ◽  
Fluid Resuscitation ◽  
Kidney Injury ◽  
Middle Income Country ◽  
Middle Income ◽  
Balanced Solutions

Objective: To evaluate the outcomes of patients with sepsis-associated organ dysfunction and septic shock who receive fluid resuscitation with balanced and unbalanced solutions in a middle-income country. Design: An observational, analytical cohort study with propensity score matching (PSM) in children admitted to a pediatric intensive care unit (PICU). Patients from one month to 17 years old who required fluid boluses due to hemodynamic instability were included. The primary outcome was the presence of acute kidney injury and the secondary outcomes were the need to begin continuous renal replacement therapy (CRRT), metabolic acidosis, PICU length of stay and mortality. Measurements and Main Results: Out of the 1,074 admissions to the PICU during the study period, 99 patients had sepsis-associated organ dysfunction and septic shock. Propensity score matching was performed including each patient´s baseline characteristics. The median age was 9.9 months (IQR 4.9-22.2) with 55.5% of the patients being male. Acute kidney injury was seen less frequently in children who received a balanced solution than in those who received an unbalanced solution (20.3% vs 25.7% P = 0.006 ORa, 0.75; 95% CI, 0.65-0.87), adjusted for disease severity. In addition, the group that received balanced solutions had less need for CRRT (3.3 % vs 6.5%; P = 0.02 ORa 0.48; 95% CI, 0.36-0.64) and a shorter PICU stay (6 days IQR 4.4-20.2 vs 10.2 days IQR 4.7-26; P < 0.001) than the group with unbalanced solutions. We found no difference in the frequency of metabolic acidosis ( P = 0.37), hyperchloremia ( P = 0.11) and mortality ( P = 0.25) between the 2 groups. Conclusion: In children with sepsis-associated organ dysfunction and septic shock, the use of unbalanced solutions for fluid resuscitation is associated with a higher frequency of acute kidney injury, a greater need for continuous renal support and a longer PICU stay compared to the use of balanced solutions, in a middle-income country.

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