Haematology

On the taking of blood and of holidaysAnaemiaIron-deficiency anaemiaAnaemia of chronic diseaseSideroblastic anaemiaThe peripheral blood filmThe differential white cell countMacrocytic anaemiab12 deficiency and pernicious anaemiaAn approach to haemolysisCauses of haemolysisSickle-cell anaemiaThalassaemiaBleeding disorders...

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Deranged hematological profile in patients presenting with malarial parasitaemia

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20214450 ◽

2021 ◽

Author(s):

Amber Haroon ◽

Huda Zameer ◽

Aneeqa Naz ◽

Sohaib Afzal ◽

Tooba Ammar ◽

...

Keyword(s):

Platelet Count ◽

Plasmodium Vivax ◽

Blood Count ◽

Complete Blood Count ◽

Hematological Parameters ◽

Blood Film ◽

Bleeding Disorders ◽

Peripheral Blood Film ◽

Duration Of Disease ◽

Low Platelet Count

Background: Alterations in the hematological parameters are thought to have the capacity to act as an adjuvant tool in strengthening the suspicion of malaria, thereby prompting a more meticulous search for malaria parasites.Methods: 186 cases with malaria positive for immunochromatographic test (ICT) malaria presenting with fever ≥101 °F, confirmed on peripheral blood film, of 20-60 years were included. Patients with coagulopathy and bleeding disorders such as hemophilia, brain tumors, tuberculosis meningitis, viral or bacterial encephalitis and multiple sclerosis were excluded. Sample was taken to the laboratory, for routine investigations like ICT malaria and complete blood count (CBC) to diagnose anemia and low platelet count.Results: Patients of 20 to 60 years of age with mean 41.80±8.51. Out of 186 patients, 101 (54.30%) were male and 85 (45.70%) were female with 1:2:1 ratio. Mean duration of disease was 4.91±1.32 days. Frequency of derangement in hematological parameters was anemia in 27 (14.52%) patients and 142 (76.34%) with thrombocytopenia. 127 cases were of Plasmodium vivax and 59 cases were of Plasmodium falciparum. Patients were more anemic as disease period prolonged. Patients infected by Plasmodium vivax showed more tendencies towards anemia and reduction in platelet count as compare to Plasmodium falciparum.Conclusions: The frequency of derangement in hematological parameters i.e. anemia and low platelet count, among malarial patients is quite high and more cases were of Plasmodium vivax and it showed anemia and thrombocytopenia was more pronounced in Plasmodium vivax.

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Evans Syndrome: A Case Report

Bangladesh Medical Journal ◽

10.3329/bmj.v47i3.43497 ◽

2019 ◽

Vol 47 (3) ◽

pp. 37-40

Author(s):

Sunil Kumar Biswas ◽

Tonmoy Biswas ◽

Noornabi Khondoker ◽

Md Rafiqul Alam ◽

Md Abdur Rahim ◽

...

Keyword(s):

White Cell Count ◽

Iga Deficiency ◽

Blood Film ◽

Evans Syndrome ◽

Intermittent Fever ◽

Exertional Dyspnea ◽

Dark Urine ◽

Peripheral Blood Film ◽

Acquired Immunodeficiency

Evans syndrome, a combined clinical condition of autoimmune haemolytic anaemia (AHA) and idiopathic thrombocytopaenic purpura (ITP) and has non-specific pathogenesis. The clinical cases are extremely rare, since only 4% of AHA or ITP are incorporated with Evans. It is distinguished from differentials, such as lupus, IgA deficiency, and acquired immunodeficiency, by peripheral blood film, bone marrow, Coombs test, and coagulation profile. A case of adult female from Pabna, Bangladesh is documented in this report. She complained of high grade intermittent fever, exertional dyspnea, icteric skin and sclera. Other features included mild splenomegaly, dark urine, and profuse sweating after fever. Investigation reports were consistent with AHA and ITP, with normal coagulation and viral profile. However, the patient was treated with corticosteroids, platelet and blood transfusion. And in follow-up visits, there was a pattern of gradual decline in erythrocyte sedimentation rate (ESR) and reticulocyte count, with normalization of haemoglobin, red cell, and white cell count. No association with other diseases was found in this case. Bangladesh Med J. 2018 Jan; 47 (3): 37-40

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Haematology

Oxford Handbook of Clinical Medicine ◽

10.1093/med/9780199689903.003.0008 ◽

2017 ◽

pp. 322-377

Author(s):

Ian B. Wilkinson ◽

Tim Raine ◽

Kate Wiles ◽

Anna Goodhart ◽

Catriona Hall ◽

...

Keyword(s):

Myeloid Leukaemia ◽

Hodgkin’S Lymphoma ◽

Bone Marrow Failure ◽

White Cell Count ◽

Pernicious Anaemia ◽

Myeloproliferative Disorders ◽

Immunosuppressive Drugs ◽

Plasma Viscosity ◽

Blood Film ◽

Hodgkin's Lymphoma

This chapter presents all aspects of haematology, including the history of haematology, iron-deficiency anaemia, anaemia of chronic disease, sideroblastic anaemia, peripheral blood film, differential white cell count, macrocytic anaemia, B12 deficiency and pernicious anaemia, haemolytic anaemia, sickle-cell anaemia, thalassaemia, bleeding disorders, coagulations pathways, blood transfusion and blood products, anticoagulants, leukaemia and the on-call junior doctor, acute lymphoblastic leukaemia, acute myeloid leukaemia, chronic myeloid leukaemia, chronic lymphocytic leukaemia, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma, pancytopenia and bone marrow failure, myeloproliferative disorders, myeloma, paraproteinaemia, amyloidosis, erythrocyte sedimentation rate (ESR), plasma viscosity (PV), hyperviscosity syndrome, spleen and splenectomy, thrombophilia, and immunosuppressive drugs.

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Haematology

Oxford Handbook of Geriatric Medicine ◽

10.1093/med/9780199586097.003.0016 ◽

2012 ◽

pp. 451-464

Author(s):

Lesley K Bowker ◽

James D Price ◽

Sarah C Smith

Keyword(s):

Multiple Myeloma ◽

Chronic Disease ◽

Iron Deficiency ◽

Older People ◽

Myelodysplastic Syndrome ◽

Iron Deficiency Anaemia ◽

Macrocytic Anaemia ◽

Deficiency Anaemia ◽

Anaemia Of Chronic Disease ◽

Haematopoietic System

The ageing haematopoietic system 452 Investigating anaemia in older people 453 Iron deficiency anaemia: diagnosis 454 HOW TO . . . Investigate iron deficiency anaemia 455 Iron deficiency anaemia: treatment 456 Macrocytic anaemia 457 Anaemia of chronic disease 458 Paraproteinaemias 459 Multiple myeloma 460 Myelodysplasia and myelodysplastic syndrome ...

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Haematology

10.1093/med/9780198738381.003.0016 ◽

2018 ◽

Author(s):

Lesley K. Bowker ◽

James D. Price ◽

Ku Shah ◽

Sarah C. Smith

Keyword(s):

Multiple Myeloma ◽

Chronic Disease ◽

Iron Deficiency ◽

Myelodysplastic Syndrome ◽

Iron Deficiency Anaemia ◽

Lymphocytic Leukaemia ◽

Macrocytic Anaemia ◽

Deficiency Anaemia ◽

Anaemia Of Chronic Disease ◽

Haematopoietic System

This chapter provides information on the ageing haematopoietic system, investigating anaemia in older people, diagnosis of iron deficiency anaemia, treatment of iron deficiency anaemia, macrocytic anaemia, anaemia of chronic disease, paraproteinaemias, multiple myeloma, myelodysplasia and myelodysplastic syndrome, and chronic lymphocytic leukaemia.

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THE PERIPHERAL BLOOD FILM

Journal of Clinical Pathology ◽

10.1136/jcp.21.6.788-b ◽

1968 ◽

Vol 21 (6) ◽

pp. 788-788

Author(s):

A. G. Signy

Keyword(s):

Peripheral Blood ◽

Blood Film ◽

Peripheral Blood Film

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Anti-pernicious-anaemia Factor for Tropical Macrocytic Anaemia

BMJ ◽

10.1136/bmj.2.4586.934 ◽

1948 ◽

Vol 2 (4586) ◽

pp. 934-935 ◽

Cited By ~ 4

Author(s):

J. C. Patel

Keyword(s):

Pernicious Anaemia ◽

Macrocytic Anaemia

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A double blind, placebo controlled randomized evaluation of the efficacy of a Polyherbal Preparation (FaradinR) in treating sickle cell anaemia in Nigerian children

Research Journal of Health Sciences ◽

10.4314/rejhs.v9i3.6 ◽

2021 ◽

Vol 9 (3) ◽

pp. 254-263

Author(s):

D.G. Gbadero ◽

T.A. Olutogun ◽

K.J. Olufemi-Aworinde ◽

L.P. Oluwadare ◽

A.T. Abolarin ◽

...

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

White Cell Count ◽

Randomized Study ◽

Organ Damage ◽

Exclusion Criterion ◽

Double Blind ◽

Hemoglobin F ◽

Transfusion Requirements ◽

Alternative Medications

Introduction: The goal of management of sickle cell anaemia (SCA), for many years, has been to manage acute intermittent crises and slow down chronic end organ damage. In the past few decades, with increasing understanding of its pathophysiology, compounds primarily preventive in action are being investigated and used. Faradin® (a poly-herbal traditional supplement mixture) has been used aspreventive measure against painful episodes by SCA patients as an over the counter medication and anecdotal evidence suggests that it reduced the frequency and severity of painful crises as well as transfusion requirements. Alternative medications that are both affordable and available should be considered viable alternatives provided safety and efficacy are assured because of the high disease burden in Nigeria.Methods: This was a double controlled randomized study was carried out on twenty children. Each enrolled patient was randomized into either the herbal mixture or placebo after permission to participate in the study was obtain from the parents/guardian for children below 15 years or from both parents/guardian and the patients where the latter are older than 15 years. The main exclusion criterion was prior use or exposure to Faradin. Primary end points were pain alteration, death during study and blood transfusion frequency. Secondary endpoints were hemoglobin levels, neutrophil count, platelet count, hemoglobin F and A2 levels, serum bilirubin, nitric oxide concentration, drug toxicity and severe complications of sickle cell anemia reported during the study.Results: There was no severe adverse event, deaths or transfusion recorded in the two groups throughout the duration of the study. Mean hematocrit was increased in the Faradin group and reticulocyte count was increased by 12 %. Faradin reduced the total white cell count to half its baseline level and increased hemoglobin F levels by 10%. Weight and appetite were reported to increased and engenders a generalfeeling of wellbeing.Conclusion: Faradin appears to be an efficacious, nontoxic, available and affordable remedy for treating SCA patients in our setting.

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