scholarly journals Deranged hematological profile in patients presenting with malarial parasitaemia

2021 ◽  
Author(s):  
Amber Haroon ◽  
Huda Zameer ◽  
Aneeqa Naz ◽  
Sohaib Afzal ◽  
Tooba Ammar ◽  
...  
Keyword(s):  
Platelet Count ◽  
Plasmodium Vivax ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Blood Film ◽  
Bleeding Disorders ◽  
Peripheral Blood Film ◽  
Duration Of Disease ◽  
Low Platelet Count

Background: Alterations in the hematological parameters are thought to have the capacity to act as an adjuvant tool in strengthening the suspicion of malaria, thereby prompting a more meticulous search for malaria parasites.Methods: 186 cases with malaria positive for immunochromatographic test (ICT) malaria presenting with fever ≥101 °F, confirmed on peripheral blood film, of 20-60 years were included. Patients with coagulopathy and bleeding disorders such as hemophilia, brain tumors, tuberculosis meningitis, viral or bacterial encephalitis and multiple sclerosis were excluded. Sample was taken to the laboratory, for routine investigations like ICT malaria and complete blood count (CBC) to diagnose anemia and low platelet count.Results: Patients of 20 to 60 years of age with mean 41.80±8.51. Out of 186 patients, 101 (54.30%) were male and 85 (45.70%) were female with 1:2:1 ratio. Mean duration of disease was 4.91±1.32 days. Frequency of derangement in hematological parameters was anemia in 27 (14.52%) patients and 142 (76.34%) with thrombocytopenia. 127 cases were of Plasmodium vivax and 59 cases were of Plasmodium falciparum. Patients were more anemic as disease period prolonged. Patients infected by Plasmodium vivax showed more tendencies towards anemia and reduction in platelet count as compare to Plasmodium falciparum.Conclusions: The frequency of derangement in hematological parameters i.e. anemia and low platelet count, among malarial patients is quite high and more cases were of Plasmodium vivax and it showed anemia and thrombocytopenia was more pronounced in Plasmodium vivax.

Normal Reference Values of Complete Blood Count in Healthy Adult Population of Pakistan; A Multicentre Study

2021 ◽  
Vol 15 (11) ◽  
pp. 3040-3042
Author(s):  
Neelam Mazhar ◽  
Sarah Rafi ◽  
Saima Farhan ◽  
Shazia Yaseen ◽  
Nisar Ahmed
Keyword(s):  
Reference Values ◽  
Blood Count ◽  
Blood Donors ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Adult Population ◽  
Armed Forces ◽  
Reference Ranges ◽  
Medical College ◽  
Normal Reference

Aim: To establish the reference values of hematological parameters in blood donors of all the four provinces of Pakistan as a general population. Methods: This was a multicenter cross-sectional study conducted from Jan 2017-Oct 2017 in the blood bank and the Dept. of Haematology, The CH&ICH, Lahore, Fatimid Foundation, Karachi, Bolan medical college, Quetta, Armed Forces Institute of Transfusion, Rawalpindi & Ayub medical college, Abbottabad, KPK. Blood samples of 1060 male and female blood donors were collected from the blood banks of all the centers mentioned above. CBC and differential were performed using an automated hematology analyzer in the respective departments. Results: The mean and 95% reference values (2.5th-97.5th) for males WBC 7.752+4.506×109 cells/L, RBC 4.958 +1.331, HB 14.258 +3.423 g/dl, HCT 41.967 +16.345, MCV 84.584 +15.933, PLT 219.485 +197.331, LYM 3.346 +10.112, NEUT 6.843+23.557, MONO 0.811 +3.601, EO 0.327 +0.995. For females WBC 7.174+3.037, RBC4.567 +1.086, HB 12.972 +2.752, HCT39.647 +48.186, PLT 264.07+175.079, LYM 2.537+5.005, NEUT 4.769+11.314, MONO 0.460 +0.909, EO 0.188+0.39 Conclusion: The hematological profile of the population in all four provinces of Pakistan differed from the reports of other countries and the standard reference ranges described in the textbook. So, our own hematological parameters must be followed. More studies must be carried out on other age groups and even on adults to strengthen our results. Keywords: Normal reference values, Complete blood count, Healthy adults of Pakistan

scholarly journals Ethylenediaminetetraacetic Acid‑Dependent Pseudothrombocytopenia in Patient Previously Treated as Dengue Fever

2021 ◽  
Vol 17 (1) ◽  
pp. 65
Author(s):  
Hendra Wana Nur’amin ◽  
Muhammad Darwin Prenggono ◽  
Wivina Riza Devi
Keyword(s):  
Bone Marrow ◽  
Platelet Count ◽  
Dengue Fever ◽  
Complete Blood Count ◽  
Ethylenediaminetetraacetic Acid ◽  
Bone Marrow Aspiration ◽  
Normal Platelet ◽  
Low Platelet Count ◽  
Bleeding Manifestation ◽  
Secondary Hospital

Abstract: One of the most widely used anticoagulants for a complete blood count is ethylenediaminetetraacetic acid (EDTA).  Pseudothrombocytopenia (PTCP) may be caused by EDTA, this condition may lead to inappropriate diagnosis and treatment. We report a 25-year-old female with unspecific headache and joint pain with very low platelet count since 1 month before hospital admission. She was diagnosed with Dengue fever infection and got some platelet transfusion from the previous secondary hospital. She was carried out for a blood test with another anticoagulant (sodium citrate) and bone marrow aspiration. The results showed that she had normal platelet count and bone marrow cellularity. When a patient was identified with thrombocytopenia without any bleeding manifestation, hematology disease, and family history, PTCP should be taken into consideration to prevent unnecessary intervention. Keywords: platelet, pseudothrombocytopenia, ethylenediaminetetraacetic acid, Dengue fever

scholarly journals Hematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M'diq-Fnideq provinces)

2018 ◽  
Vol 29 ◽  
Author(s):  
Saad Bakrim ◽  
Youssef Motiaa ◽  
Ali Ouarour ◽  
Azlarab Masrar
Keyword(s):  
Pregnant Women ◽  
Reference Values ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Healthy Population ◽  
Corpuscular Hemoglobin ◽  
Significant Difference

Introduction: numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature. Methods: blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N® analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential. Results: a statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001). Conclusion: the present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.

scholarly journals Relationship between CBC and ESR and duration of disease in patients with systemic lupus erythematosus (SLE)

2018 ◽  
Vol 13 (2) ◽  
pp. 41-46
Author(s):  
Mahmuda Abira ◽  
Qazi Shamima Akhter
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Systemic Lupus ◽  
Initial Manifestation ◽  
Cross Sectional ◽  
Duration Of Disease

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease and is associated with considerable morbidity. Hematological abnormalities may be the initial manifestation. Duration may have impact on their hematological parameters. Objective: To observe the relationship of Complete Blood Count (CBC) and Erythrocyte sedimentation Rate(ESR) with duration of disease in patients with SLE. Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2016 to June 2017. Total 60 subjects including both sexes were selected with age ranging from 18 to 55 years. Among them, 30 subjects with SLE were study group and 30 age matched healthy subjects were control group. Total count of RBC, WBC, Platelet and ESR were estimated by automated hematology analyzer. Statistical analysis was done by unpaired Students æt” test, Chi Square test and Pearson’s correlation coefficient (r) test. Results: In this study, ESR was significantly (p<0.001) higher and RBC,WBC and platelet counts were significantly (p<0.001) lower in SLE patients in comparison to that of control. On correlation analysis, RBC and WBC showed significant negative correlation with duration of disease in patients with SLE. Conclusion: This study concludes that CBC and ESR were altered in SLE patients and it was related to duration of disease. J Bangladesh Soc Physiol. 2018, December; 13(2): 41-46

Haematology

2014 ◽  
Author(s):  
Murray Longmore ◽  
Ian B. Wilkinson ◽  
Andrew Baldwin ◽  
Elizabeth Wallin
Keyword(s):  
Iron Deficiency Anaemia ◽  
Sickle Cell Anaemia ◽  
White Cell Count ◽  
Pernicious Anaemia ◽  
Blood Film ◽  
Bleeding Disorders ◽  
Macrocytic Anaemia ◽  
Sideroblastic Anaemia ◽  
Anaemia Of Chronic Disease ◽  
Peripheral Blood Film

On the taking of blood and of holidaysAnaemiaIron-deficiency anaemiaAnaemia of chronic diseaseSideroblastic anaemiaThe peripheral blood filmThe differential white cell countMacrocytic anaemiab12 deficiency and pernicious anaemiaAn approach to haemolysisCauses of haemolysisSickle-cell anaemiaThalassaemiaBleeding disorders...

scholarly journals M2G1G2 white blood cell flag by three-part automated hematology analyzer: A hint to dengue infection in appropriate clinical context

2019 ◽  
Vol 11 (02) ◽  
pp. 103-106
Author(s):  
Maitrayee Roy ◽  
Akshay Bali
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Dengue Infection ◽  
Blood Film ◽  
Clinical Context ◽  
Normal Limits ◽  
Hematology Analyzer ◽  
Automated Hematology Analyzer

Abstract BACKGROUND: Automated hematology analyzers often generate many flags which can provide important clues to the underlying hematological abnormality. Although pathologists are generally well versed in recognizing the importance of flags indicating potential leukemic blasts, their utility in hinting toward infectious etiology, especially during epidemics, is less well known. We analyzed any abnormal flags generated by a three-part automated hematology analyzer in serologically confirmed cases of dengue. MATERIALS AND METHODS: The study included 28 patients diagnosed with serologically confirmed dengue infection. The venous samples were run on ABX Miros-60 three-part hematology analyzer. The complete blood count data and any abnormal flags were noted and correlated with peripheral blood film findings in all patients. RESULTS: An abnormal white blood cell (WBC) flag was noted in all 28 patients, including two in whom all other hematological parameters were within normal limits. In 26 (93%) patients, M2G1G2 WBC flag was noted while the samples of the remaining two patients generated M2G1 and L1M2G1G2 WBC flags, respectively. CONCLUSION: An abnormal WBC flag, when correlated in appropriate clinical context, especially during a dengue outbreak, can aid in targeting the cohort of patients who will require immediate referral for serological confirmation.

Is anti-D immunoglobulin still a frontline treatment option for immune thrombocytopenia?

Hematology ◽  
2013 ◽  
Vol 2013 (1) ◽  
pp. 283-285 ◽  
Author(s):  
Jenny M. Despotovic ◽  
Cindy E. Neunert
Keyword(s):  
Platelet Count ◽  
Treatment Option ◽  
Drug Administration ◽  
Immune Thrombocytopenia ◽  
Blood Count ◽  
Complete Blood Count ◽  
Initial Therapy ◽  
Black Box ◽  
Frontline Treatment ◽  
Mucosal Bleeding

Abstract A 5-year-old boy presents with platelet count of 2 × 109/L and clinical and laboratory evidence of immune thrombocytopenia. He has epistaxis and oral mucosal bleeding. Complete blood count reveals isolated thrombocytopenia without any decline in hemoglobin and he is Rh+. You are asked if anti-D immunoglobulin is an appropriate initial therapy for this child given the 2010 Food and Drug Administration “black-box” warning.

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