Bladder stones

Author(s):  
John Reynard ◽  
Ben Turney

The majority of bladder stones in Western practice are secondary to underlying pathology—bladder outlet obstruction due to benign prostatic enlargement in men and urethral obstruction from pelvic prolapse or cystocele in women, chronic infection in the neuropathic or augmented bladder, or in the neobladder. While the pathology of endemic bladder stones remains as it always was, the advent of augmentation cystoplasty and rising use of the neobladder after cystectomy has, through a different pathological mechanism, led to a rise in frequency of bladder stones. The mode of presentation of bladder stones and diagnostic technique are reviewed in this chapter. Treatment options are determined, to a significant degree, by the clinical context in which the stone arise, the major determinant of the approach to such stones being the calibre of the conduit (urethra or Mitrofanoff) through which access to the bladder is achieved.

2015 ◽  
Vol 95 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Hoon Choi ◽  
Ji Sung Sim ◽  
Jae Young Park ◽  
Jae Hyun Bae

Aims: To estimate efficacy and treatment satisfaction with tamsulosin 0.2 mg in patients with symptomatic bladder outlet obstruction secondary to benign prostatic enlargement and lower urinary tract symptoms in relation to personal satisfaction. Methods: The study was conducted in 1,260 subjects who were asked to fill in detailed questionnaires designed to evaluate their satisfaction with the treatment and symptom improvement 8 weeks after receiving tamsulosin 0.2 mg. Results: After being treated with tamsulosin 0.2 mg for 8 weeks, the International Prostate Symptom Score (IPSS) score improved significantly. Among the 1,260 patients, 813 (64.52%) were satisfied, while 447 (35.48%) were dissatisfied with tamsulosin 0.2 mg. The reasons for patient dissatisfaction were efficacy problems (79.87%) and side effects (4.25%). Treatment satisfaction was affected by age, underlying medical disease and baseline IPSS severity (p = 0.020, 0.0427 and <0.001, respectively), but only age and baseline IPSS were risk factors for dissatisfaction. Conclusions: Tamsulosin 0.2 mg was effective in symptomatic improvement, but a relatively high proportion of patients were dissatisfied with the treatment. Efficacy problems were selected by patients as the main reason for dissatisfaction. It is also significant to note that the degree of satisfaction was related to age and baseline IPSS severity.


2005 ◽  
Vol 4 (3) ◽  
pp. 187
Author(s):  
A. Kalantzis ◽  
A. Argiropoulos ◽  
O. Aristas ◽  
K. Doumas ◽  
I. Gkialas ◽  
...  

1970 ◽  
Vol 16 (1) ◽  
Author(s):  
Basuki B Purnomo ◽  
I Wayan Widharse ◽  
Aulani’am Aulani’am

OBJECTIVE: To prove that glucose treatment in human prostatic stromal cells (HPSC) culture would increase PKC alpha isozyme activity. MaterialS & Methods: Primary cultures of HPSC were obtained from patients with bladder outlet obstruction caused by benign prostatic enlargement. The effects of various concentrations of glucose (5, 10, 15, 20, 25, 30, 35 micro-Mol) on PKC-alpha isozyme activity were examined quantitatively by spectrophotometry methods. ResultS: Spectrophotometry analysis, which is used to assess isozyme activity quantitatively, showed that exposures to various doses of glucose resulted in increased isozyme activity. The increment of activity is linear with the increment of glucose dose. There is a strong correlation between glucose doses and PKC-alpha activity, with R2 = 0,91. Conclusion: At different concentrations glucose increases PKC-alpha isozyme activity of HPSC.


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