Haematological investigations

10.1093/med/9780199683307.003.0016 ◽

2015 ◽

Author(s):

Drew Provan ◽

Trevor Baglin ◽

Inderjeet Dokal ◽

Johannes de Vos

Keyword(s):

Blood Count ◽

Human Leucocyte Antigen ◽

Plasma Viscosity ◽

Blood Film ◽

Hla Typing ◽

Full Blood Count

Full blood count - Blood film - Plasma viscosity - ESR - Haematinic assays - Haemoglobin electrophoresis - Haptoglobin - Schumm’s test - Kleihauer test - Reticulocytes - Urinary haemosiderin - Ham’s test - Immunophenotyping - Cytogenetics - Human leucocyte antigen (HLA) typing

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Introduction to haematology

Oxford Textbook of Medicine ◽

10.1093/med/9780198746690.003.0510 ◽

2020 ◽

pp. 5169-5171

Author(s):

Chris Hatton

Keyword(s):

Bone Marrow ◽

Weight Loss ◽

Diagnostic Tests ◽

Blood Count ◽

Modern Medicine ◽

Blood Film ◽

Full Blood Count ◽

Cellular Infiltration ◽

Haematological Disorder ◽

History Of

Haematology is the study of the composition, function, and diseases of the blood. The approach to a patient suspected of having a haematological disorder begins with taking a history (particularly noting fatigue, weight loss, fever, and history of bleeding) and performing a clinical examination (looking for signs of anaemia, infection, bleeding, and signs of cellular infiltration causing splenomegaly and/or lymphadenopathy). Key investigations include a full blood count, a blood film, and (in selected cases) examination of the bone marrow. Further diagnostic tests now routinely performed on blood and marrow samples include immunophenotyping and cytogenetic and molecular analysis. Mutational signatures may be diagnostically useful and potentially define treatment, keeping haematology in the vanguard of advances in modern medicine.

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Interpreting the full blood count

InnovAiT Education and inspiration for general practice ◽

10.1177/17557380211065773 ◽

2022 ◽

pp. 175573802110657

Author(s):

Martin Haywood

Keyword(s):

Laboratory Tests ◽

Blood Count ◽

Blood Film ◽

Full Blood Count ◽

State Of Health ◽

General State ◽

Blood Tests ◽

Morphological Findings ◽

Individual Laboratory ◽

Clinical Presentations

The full blood count (FBC) is one of the most commonly requested blood tests in medical practice and can provide a wealth of useful information about a patient’s general state of health, as well as highlighting abnormalities which indicate systemic or sinister pathologies. This article seeks to explore the different parameters of the FBC, and how these relate to some more common clinical presentations, as well as their relation to morphological findings seen on the blood film. As with most investigations, differential diagnoses suggested by any individual laboratory tests are wide and are most valuable when combined with history and examination.

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Haematology

Oxford Handbook of Clinical and Laboratory Investigation ◽

10.1093/med/9780199233717.003.0003 ◽

2010 ◽

pp. 211-308 ◽

Cited By ~ 1

Keyword(s):

Platelet Count ◽

Blood Cell ◽

Cell Morphology ◽

Blood Count ◽

Iron Status ◽

Blood Film ◽

Full Blood Count ◽

Red Cell ◽

Cell Parameters ◽

Blood Cell Morphology

Full blood count 212 Red cell parameters 214 White cells 216 Platelet count 217 Peripheral blood film 218 Red cell morphology 219 Parasites on the blood film & marrow 222 White blood cell morphology 224 Assessment of iron status 226 Assessment of vitamin B12...

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Diagnosis and investigation in haematology

10.1093/med/9780199568741.003.0278 ◽

2018 ◽

Author(s):

Chris Bunch

Keyword(s):

Bone Marrow ◽

Blood Count ◽

Iliac Crest ◽

Bone Marrow Examination ◽

Needle Aspiration ◽

Blood Film ◽

Full Blood Count ◽

Clinical Context ◽

Posterior Iliac Crest ◽

Haematological Disorders

This chapter addresses the interpretation of the full blood count, blood film, bone marrow examination, and related tests in the diagnosis of haematological disorders. Examination of a stained blood film, which should always be requested if a blood count abnormality cannot readily be explained by the clinical context, may give clues to the cause of the abnormality or prove diagnostic. Examination of the bone marrow is essential to the proper evaluation and diagnosis of many haematological disorders. The simplest form of marrow examination involves needle aspiration of marrow cells from the posterior iliac crest; smears are made and stained in the same way as a blood film. Bone marrow can also be biopsied for histological examination, at the same time as marrow aspiration.

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Analysis of Full Blood Count and Bone Marrow Aspirations at Presentation in Children Diagnosed with Acute Leukaemias – A Single Centre Experience in Southern Nigeria

Journal of Cancer and Tumor International ◽

10.9734/jcti/2021/v11i230145 ◽

2021 ◽

pp. 1-8

Author(s):

G. K. Eke ◽

K. I. Korubo

Keyword(s):

Bone Marrow ◽

Acute Lymphoblastic Leukaemia ◽

Teaching Hospital ◽

Lymphoblastic Leukaemia ◽

Blood Count ◽

Paediatric Oncology ◽

Blood Film ◽

Full Blood Count ◽

Malignant Neoplasms ◽

Southern Nigeria

Introduction: Acute leukaemias are the most common malignant neoplasms in childhood, presenting with a variety of nonspecific symptoms. Though many of the recent more sophisticated methods of diagnosis have important prognostic implications, they are often not available in low- and middle-income countries. Objective: To review the full blood count and bone marrow aspirations at presentation in children diagnosed with acute leukaemias at a teaching hospital in southern Nigeria. Methodology: A retrospective survey of children with acute leukaemias admitted into the Paediatric Oncology unit of the University of Port Harcourt Teaching Hospital (UPTH), from January 2014 to December 2020. Their clinical profile, full blood count and bone marrow aspirations were analyzed using SPSS version 25.0 Results: Forty-three children aged 8 months to 17 years, with a median age of 9 years, were diagnosed with acute leukaemia within the period under review, 28 (65.1%) were males and 15 (34.9%) females, giving a M:F ratio of 1.9:1. Commonest clinical features at presentation were fever (n=28, 65.1%), pallor (n=18, 41.9%) and gum bleeding (n=16, 37.2%); while 38 (88.4%) of them presented with anaemia, 20 (46.5%) had leukocytosis and 36 (83.7%) had thrombocytopoenia with a median platelet count of 42x109/L and circulating blasts were present in the peripheral blood film of most of the patients. Acute lymphoblastic leukaemia (ALL) was the diagnosis in 30 (70%) children, and AML in 9 (21%). The bone marrow was hypercellular in 30 cases (69.8%) and erythropoiesis was depressed in 39 (90.7%) children. Conclusion: At the UPTH, children with acute leukaemias were mostly males. Fever, pallor and gum bleeding were the commonest symptoms with most of them having circulating blasts. Acute lymphoblastic leukaemia was the commonest type and bone marrow was mainly hypercellular with depressed erythropoiesis.

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