Rectal cancer

2013 ◽  
Author(s):  
Rob Glynne-Jones ◽  
Mark Harrison ◽  
David Sebag-Montefiore
Keyword(s):  
Rectal Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Preoperative Chemoradiotherapy ◽  
Preoperative Imaging ◽  
Short Course ◽  
Arc Therapy ◽  
Selection For ◽  
Postoperative Chemoradiation ◽  
Imaging Patient

Chapter 7 assesses the role of radiation therapy in rectal cancer, with emphasis on preoperative imaging, patient selection for preoperative chemoradiotherapy (CRT) and short-course preoperative radiotherapy (SCPRT), and postoperative chemoradiation. We describe the various available planning techniques. More conformal techniques such as intensity-modulated radiotherapy (IMRT), volume-modulated arc therapy (VMAT), and brachytherapy are also described. In addition, chemoradiation and radiotherapy as an adjunct to local excision and endoluminal irradiation are also reviewed.

Rectal cancer

2019 ◽  
pp. 165-195
Author(s):  
Rob Glynne-Jones ◽  
Mark Harrison
Keyword(s):  
Rectal Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Preoperative Chemoradiotherapy ◽  
Preoperative Imaging ◽  
Intensity Modulated ◽  
Short Course ◽  
Arc Therapy ◽  
Postoperative Chemoradiation ◽  
Imaging Patient

Chapter 8 assesses the role of radiation therapy in rectal cancer, with emphasis on preoperative imaging, patient selection for preoperative chemoradiotherapy and short-course preoperative radiotherapy, and postoperative chemoradiation. The various available planning techniques are described. More conformal techniques such as intensity-modulated radiotherapy, volume-modulated arc therapy, and brachytherapy are also covered. In addition, the chapter reviews chemoradiation and radiotherapy as an adjunct to local excision and endoluminal irradiation.

Rectal cancer and systemic therapy of colorectal cancer

2016 ◽  
pp. 408-443
Author(s):  
Regina Beets-Tan ◽  
Bengt Glimelius ◽  
Lars Påhlman
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Treatment Decision ◽  
Well Being ◽  
Risk Groups ◽  
Preoperative Chemoradiotherapy ◽  
Recurrence Rates ◽  
Short Course ◽  
Rectal Cancer Treatment ◽  
Long Course

In rectal cancer treatment, surgery is most important. Dissection outside the mesorectal fascia, total mesorectal excision is required for cure in most cases; a local procedure is possible in the earliest tumours. Appropriate staging is required prior to treatment decision to stratify patients into risk groups. In early tumours surgery alone is sufficient whereas in intermediate cancers local recurrence rates are too high and preoperative radiotherapy is indicated. A short-course schedule is convenient, low toxic, although some prefer long-course chemoradiotherapy. The addition of a fluoropyrimidine enhances the radiotherapy. In locally advanced tumours preoperative chemoradiotherapy is required. The value of adjuvant chemotherapy in rectal cancer is controversial, particularly if preoperative chemoradiotherapy was used. Palliative chemotherapy prolongs life and improves well-being in patients with metastatic disease. Targeted drugs further improves the results to some extent. In some patients, chemotherapy may convert non-readily resectable metastases to resectable, and result in long-term cure.

Possible role of nuclear β-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer

2017 ◽  
Vol 71 (2) ◽  
pp. 227-237 ◽  
Author(s):  
Hiroyuki Takahashi ◽  
Kie Nakamura ◽  
Akane Usami ◽  
Tomoko Tsuruta ◽  
Miki Hashimura ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Preoperative Chemoradiotherapy ◽  
Locally Advanced Rectal Cancer

ROLE OF PRE-OPERATIVE SHORT COURSE RADIATION IN FRAIL PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER (LARC)

2019 ◽  
Vol 10 (6) ◽  
pp. S36
Author(s):  
G. Soler ◽  
J.González Viguera ◽  
M.Martinez Villacampa ◽  
F. Losa ◽  
R. Frago ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Frail Patients ◽  
Short Course

Rectal cancer and systemic therapy of colorectal cancer

2016 ◽  
pp. 408-443
Author(s):  
Regina Beets-Tan ◽  
Bengt Glimelius
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Treatment Decision ◽  
Well Being ◽  
Risk Groups ◽  
Preoperative Chemoradiotherapy ◽  
Recurrence Rates ◽  
Short Course ◽  
Rectal Cancer Treatment ◽  
Long Course

In rectal cancer treatment, surgery is most important. Dissection outside the mesorectal fascia, total mesorectal excision is required for cure in most cases; a local procedure is possible in the earliest tumours. Appropriate staging is required prior to treatment decision to stratify patients into risk groups. In early tumours surgery alone is sufficient whereas in intermediate cancers local recurrence rates are too high and preoperative radiotherapy is indicated. A short-course schedule is convenient, low toxic, although some prefer long-course chemoradiotherapy. The addition of a fluoropyrimidine enhances the radiotherapy. In locally advanced tumours preoperative chemoradiotherapy is required. The value of adjuvant chemotherapy in rectal cancer is controversial, particularly if preoperative chemoradiotherapy was used. Palliative chemotherapy prolongs life and improves well-being in patients with metastatic disease. Targeted drugs further improves the results to some extent. In some patients, chemotherapy may convert non-readily resectable metastases to resectable, and result in long-term cure.

The Role of Preoperative Imaging for the Treatment of Locally Recurrent Rectal Cancer

2003 ◽  
Vol 7 (3) ◽  
pp. 31-38
Author(s):  
H. Rutten ◽  
T. Kuipers ◽  
G. Nieuwenhuijzen ◽  
R. Klaassen ◽  
Y. v Riet ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Recurrent Rectal Cancer ◽  
Preoperative Imaging ◽  
Locally Recurrent Rectal Cancer ◽  
Locally Recurrent

scholarly journals The value of brachytherapy in the age of advanced external beam radiotherapy: a review of the literature in terms of dosimetry

2021 ◽  
Author(s):  
Tibor Major ◽  
Georgina Fröhlich ◽  
Péter Ágoston ◽  
Csaba Polgár ◽  
Zoltán Takácsi-Nagy
Keyword(s):  
Cancer Treatment ◽  
External Beam Radiotherapy ◽  
Intensity Modulated Radiotherapy ◽  
High Tech ◽  
External Beam ◽  
Review Of The Literature ◽  
Comprehensive Literature Review ◽  
Dose Planning ◽  
Arc Therapy

AbstractBrachytherapy (BT) has long been used for successful treatment of various tumour entities, including prostate, breast and gynaecological cancer. However, particularly due to advances in modern external beam techniques such as intensity-modulated radiotherapy (IMRT), volume modulated arc therapy (VMAT) and stereotactic body radiotherapy (SBRT), there are concerns about its future. Based on a comprehensive literature review, this article aims to summarize the role of BT in cancer treatment and highlight its particular dosimetric advantages. The authors conclude that image-guided BT supported by inverse dose planning will successfully compete with high-tech EBRT in the future and continue to serve as a valuable modality for cancer treatment.

Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients

1998 ◽  
Vol 41 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Chuan-Gang Fu ◽  
Osamu Tominaga ◽  
Hirokazu Nagawa ◽  
Marcelo Eidi Nita ◽  
Tadahiko Masaki ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Patient Selection ◽  
Preoperative Radiotherapy ◽  
Selection For ◽  
P21 Waf1

scholarly journals Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc

Oncotarget ◽  
2017 ◽  
Vol 8 (47) ◽  
pp. 82294-82302 ◽  
Author(s):  
Raquel Conde-Muiño ◽  
Carlos Cano ◽  
Victoria Sánchez-Martín ◽  
Antonio Herrera ◽  
Ana Comino ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Preoperative Chemoradiotherapy
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