scholarly journals Systemic Sepsis following Hemorrhagic Shock: Alleviation with Oral Interleukin-6

1997 ◽  
Vol 162 (5) ◽  
pp. 366-370 ◽  
Author(s):  
Florence M. Rollwagen ◽  
Ying-Yue Y. Li ◽  
Nancy D. Pacheco ◽  
Shahida Baqar
Keyword(s):  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Systemic Sepsis

Shenfu injection improves cerebral microcirculation and reduces brain injury in a porcine model of hemorrhagic shock; SFI reduces brain injury after hemorrhagic shock

2021 ◽  
pp. 1-11
Author(s):  
Junyuan Wu ◽  
Zhiwei Li ◽  
Wei Yuan ◽  
Qiang Zhang ◽  
Yong Liang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Aquaporin 4 ◽  
Flow Index ◽  
Sham Operation ◽  
Volume Resuscitation ◽  
Cerebral Microcirculation ◽  
Shenfu Injection ◽  
Tnf Α

BACKGROUND: Shenfu injection (SFI) is a traditional Chinese herbal medicine which has been clinically used for treatment of septic shock and cardiac shock. The aim of this study was to clarify effects of SFI on cerebral microcirculation and brain injury after hemorrhagic shock (HS). METHODS: Twenty-one domestic male Beijing Landrace pigs were randomly divided into three groups: SFI group (SFI, n = 8), saline group (SA, n = 8) or sham operation group (SO, n = 5). In the SFI group, animals were induced to HS by rapid bleeding to a mean arterial pressure of 40 mmHg within 10 minutes and maintained at 40±3 mmHg for 60 minutes. Volume resuscitation (shed blood and crystalloid) and SFI were given after 1 hour of HS. In the SA group, animals received the same dose of saline instead of SFI. In the SO group, the same surgical procedure was performed but without inducing HS and volume resuscitation. The cerebral microvascular flow index (MFI), nitric oxide synthase (NOS) expression, aquaporin-4 expression, interleukin-6, tumor necrosis factor-α (TNF-α) and ultrastructural of microvascular endothelia were measured. RESULTS: Compared with the SA group, SFI significantly improved cerebral MFI after HS. SFI up regulated cerebral endothelial NOS expression, but down regulated interleukin-6, TNF-α, inducible NOS and aquaporin-4 expression compared with the SA group. The cerebral microvascular endothelial injury and interstitial edema in the SFI group were lighter than those in the SA group. CONCLUSIONS: Combined application of SFI with volume resuscitation after HS can improve cerebral microcirculation and reduce brain injury.

Shenfu Injection Improves Cerebral Microcirculation and Reduces Brain Injury in a Porcine Model of Hemorrhagic Shock

2020 ◽  
Author(s):  
Junyuan Wu ◽  
Zhiwei Li ◽  
Wei Yuan ◽  
Qiang Zhang ◽  
Yong Liang ◽  
...  
Keyword(s):  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Aquaporin 4 ◽  
Flow Index ◽  
Sham Operation ◽  
Volume Resuscitation ◽  
Cerebral Microcirculation ◽  
Sham Operation Group ◽  
Tnf Α

Abstract Background: The aim of this study was to clarify effects of Shenfu infusion (SFI) on cerebral microcirculation and brain injury after hemorrhagic shock (HS).Methods: Twenty-one domestic male Beijing Landrace pigs were randomly divided into three groups: SFI group (SFI, n=8), saline group (SA, n=8) or sham operation group (SO, n=5). In the SFI group, animals were induced to HS by rapid bleeding to a mean arterial pressure of 40 mmHg within 10 minutes and maintained at 40 ± 3 mmHg for 60 minutes. Volume resuscitation (shed blood and crystalloid) and SFI were given after 1 hour of HS. In the SA group, animals received the same dose of saline instead of SFI. In the SO group, the same surgical procedure was performed but without inducing HS and volume resuscitation. The cerebral microvascular flow index (MFI), nitric oxide synthase (NOS) expression, aquaporin-4 expression, interleukin 6, tumor necrosis factor-α (TNF-α) and ultrastructural of microvascular endothelia were measured.Results: Compared with the SA group, SFI significantly improved cerebral MFI after HS. SFI up regulated cerebral endothelial NOS expression, but down regulated interleukin 6, TNF-α, inducible NOS and aquaporin-4 expression compared with the SA group. The cerebral microvascular endothelial injury and interstitial edema in the SFI group were lighter than those in the SA group.Conclusions: Combined application of SFI with volume resuscitation after HS can improve cerebral microcirculation and reduce brain injury.

GLUTAMINE DIPEPTIDES-SUPPLEMENTED PARENTERAL NUTRITION REVERSES GUT MUCOSAL STRUCTURE AND INTERLEUKIN-6 RELEASE OF RAT INTESTINAL MONONUCLEAR CELLS AFTER HEMORRHAGIC SHOCK

Shock ◽  
1998 ◽  
Vol 10 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Jörg Schröder ◽  
Volker Kahlke ◽  
Fred Fändrich ◽  
Hinnerk Gebhardt ◽  
Hartmut Erichsen ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Mononuclear Cells

Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock

1999 ◽  
Vol 119 (5-6) ◽  
pp. 332-336 ◽  
Author(s):  
Christian Hierholzer ◽  
Joerg C. Kalff ◽  
Brian Bednarski ◽  
Farnaz Memarzadeh ◽  
Young-Myeong Kim ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Simultaneous Activation

Cortisol Response to Corticotropin Stimulation in Trauma Patients

2002 ◽  
Vol 97 (4) ◽  
pp. 807-813 ◽  
Author(s):  
Sophie Hoen ◽  
Karim Asehnoune ◽  
Sylvie Brailly-Tabard ◽  
Jean-Xavier Mazoit ◽  
Dan Benhamou ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Interleukin 6 ◽  
Early Phase ◽  
Injury Severity ◽  
Late Phase ◽  
Early Response ◽  
Adrenocortical Function ◽  
Trauma Patients ◽  
Cortisol Response ◽  
Corticotropin Stimulation

Background An abnormal adrenocortical function and a vasopressor dependency have been demonstrated during septic shock. Because trauma and hemorrhage are the leading causes of noninfectious inflammatory syndromes, the goal of this study was to assess the adrenal reserve of trauma patients and its relation with clinical course. Methods Cortisol response to an intravenous corticotropin bolus was obtained in 34 young trauma patients (Injury Severity Score =29.1 +/- 7.3) at the end of the resuscitative period ("early phase") and at the end of the first posttraumatic week ("late period"). Cortisol response less than +9 g/dl defined an impaired adrenal function, and the corresponding patient was called a nonresponder. According to the early response, hemorrhagic shock, circulating interleukin-6, need for vasopressor therapy, subsequent organ dysfunction and infection, and outcomes were studied. Results Sixteen patients (47%) were nonresponders at the end of the early phase. Hemorrhagic shock was more frequent (69 vs. 28%; = 0.037) and interleukin-6 concentrations were higher (728 +/- 589 vs. 311 +/- 466 pg/ml; = 0.048) in these patients. The early cortisol responses were negatively correlated with the concomitant interleukin-6 serum concentrations (r(2) = 0.298; = 0.003). Four early nonresponders (and shock patients) remained nonresponders during the late phase (25%). Morbidity and mortality were similar in early nonresponders and responders. The duration of norepinephrine treatment and the total amount of infused drug were significantly higher in early nonresponders. Conclusions A sustained impairment of adrenal reserve is frequently observed in trauma patients. This abnormal cortisol response to corticotropin stimulation is related with the inflammatory consequences of hemorrhagic shock and is followed by a prolonged vasopressor dependency.

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