scholarly journals Decreased protamine-1 transcript levels in testes from infertile men

2003 ◽  
Vol 9 (6) ◽  
pp. 331-336 ◽  
Author(s):  
K. Steger
Keyword(s):  
Transcript Levels ◽  
Infertile Men ◽  
Protamine 1

Comparison of polymorphism 139C > A ( (rs737008) of protamine 1 gene in infertile men with diagnosis of oligospermia and asthenospermia

Meta Gene ◽  
2021 ◽  
pp. 100978
Author(s):  
Mehdi Mohsenzadeh ◽  
Aliyar Pirouzi ◽  
Seyedeh Fereshteh Saadat ◽  
Mahmood Dehghani Ashkezari
Keyword(s):  
Infertile Men ◽  
Protamine 1

Round spermatids from infertile men exhibit decreased protamine-1 and -2 mRNA

2001 ◽  
Vol 16 (4) ◽  
pp. 709-716 ◽  
Author(s):  
Klaus Steger ◽  
Klaus Failing ◽  
Thomas Klonisch ◽  
Hermann M. Behre ◽  
Martina Manning ◽  
...  
Keyword(s):  
Infertile Men ◽  
Protamine 1

scholarly journals Sperm DNA Damage and Protamine Transcripts Content in Iranian Men with Unexplained Infertility

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mehran Dorostghoal ◽  
Hamid Galehdari ◽  
Masoud Hemadi ◽  
Saba Abdi
Keyword(s):  
Dna Damage ◽  
Dna Fragmentation ◽  
Chromatin Condensation ◽  
Normal Morphology ◽  
Transcript Levels ◽  
Sperm Dna Damage ◽  
Infertile Men ◽  
Sperm Dna ◽  
Polymerase Chain ◽  
Infertile Patients

Background: Incomplete chromatin condensation caused by altered amount of sperm protamines results in DNA fragmentation, which in turn leads to a lack of success in the development of the human embryo. Objectives: This study evaluated the sperm DNA damage and protamine transcripts content in Iranian normozoospermic fertile and infertile men. Methods: DNA damage was analyzed using comet assay. Transcript levels of protamine-1 (PRM1) and protamine-2 (PRM2) in ejaculated spermatozoa were assessed by quantitative real-time polymerase chain reaction (PCR). Results: Significantly higher levels of DNA damage were observed in unexplained infertile men (P = 0.001). DNA fragmentation correlated significantly with sperm total motility (r = -0.413, P = 0.032) and normal morphology (r = -0.424, P = 0.028). PRM1 and PRM2 transcripts contents were significantly lower in normozoospermic infertile men than healthy controls. Sperm PRM1 and PRM2 mRNA ratios were significantly higher (P = 0.035) in unexplained infertile patients than fertile men. Higher DNA damage was found to be significantly associated with reduced transcript levels of PRM1 (r = -0.453, P = 0.018) and PRM2 (r = -0.492, P = 0.009). Protamine transcripts ratios were significantly correlated with sperm normal morphology (r = -0.421, P = 0.029). Conclusions: Our findings showed the prognostic value and clinical utility of the sperm DNA damage and protamine transcripts contents for the discrimination between healthy fertile and unexplained infertile men.

1356: The Reversibility of Hyperthermia Effects on Semen Quality in Infertile Men

2005 ◽  
Vol 173 (4S) ◽  
pp. 368-368
Author(s):  
Shai Shefi ◽  
Phiroz Tarapore ◽  
Paul J. Turek
Keyword(s):  
Semen Quality ◽  
Infertile Men

1574: The Incidence of Testicular Cancer in Infertile Men

2004 ◽  
Vol 171 (4S) ◽  
pp. 415-415
Author(s):  
Deborah M. Spaine ◽  
Renato Fraietta ◽  
Carolina Homsi ◽  
Agnaldo P. Cedenho ◽  
Miguel Srougi
Keyword(s):  
Testicular Cancer ◽  
Infertile Men

1386: Role of Seminal Growth Factors in Infertile Men with Varicocele

2004 ◽  
Vol 171 (4S) ◽  
pp. 365-365
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Mohamed A. Bedaiwy ◽  
...  
Keyword(s):  
Growth Factors ◽  
Infertile Men

The correlation between the sociodemographic characteristics and some hormones with the infertility of women and men

10.32947/357 ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 1-10
Keyword(s):  
Soft Drink ◽  
Serum Prolactin ◽  
Age Group ◽  
Tea Consumption ◽  
Obese Women ◽  
Overweight Women ◽  
Infertile Women ◽  
Infertile Men ◽  
Overweight Group ◽  
Prolactin Hormone

Thirty three infertile women were divided into two groups according to their BMI (21 obese and 12 overweight) there age ranges between (16-41) years, with their husbands twenty one infertile men and twelve fertile men and their ages range between (23-46) years. In the present study we observed that several indicators affect the fertility such as BMI in infertile obese women which was 34.65 kg/m2. That is higher than that of overweight infertile women that recorded 24.87 kg/m2. obese housewives scored the highest percentage (85.71%) compared with the overweight group (25%), In addition the obese age group between 30-41 years scored (66.67%) compared with the overweight group whose members’ age 16-29.9 years scored 75%. However, drinking cola (soft drink) percentage in obese infertile women was (85.71%) and the tea consumption was higher in overweight group (66.67%). The hormones FSH and LH decrease in obese women but serum prolactin hormone increased twice about 29.27 ng/ml in comparison with overweight group. Testosterone hormone decreased in obese women but Leptin in obese women (19.52 μg/L) was higher than that of overweight women (11.03 μg/L). Infertile unemployed men got the highest percentage of 66.67%. Besides, the smoker infertile men were higher in percentage (80.95%) compared with fertile men 41.67%. The elevated LH, FSH and prolactin values are significantly high (p<0.01) (7.895 mlU/ml, 9.89 mlU/ml and 13.33 ng/ml) respectively, but the testosterone was significantly low (3.91 ng/dl) in comparison with fertile men(21.76ng/dl). Whileleptin significantly increased in infertile men more than the fertile ones. These changes in hormones have a great correlation with semen characteristics as the abnormalities in sperms increased to (64.52) and the percentage of rapid, progressive and non -progressive motility decreased, but the immotile motility was highly significant (65.71) in infertile men. As a result this indicates that the reason of infertility is shared between the wife and husband.

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