scholarly journals Demarcation of a sequence involved in mediating catabolite repression of the gene for the 11 kDa subunit VIII of ubiquinol-cytochrome c oxidoreductase in Saccharomyces cerevisiae

1988 ◽  
Vol 16 (13) ◽  
pp. 5797-5811 ◽  
Author(s):  
A.C. Maarse ◽  
M. de Haan ◽  
A. Bout ◽  
L.A. Grivell
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cytochrome C ◽  
Catabolite Repression

scholarly journals DELETIONS OF THE ISO-1-CYTOCHROME c AND ADJACENT GENES OF YEAST: DISCOVERY OF THE OSM1 GENE CONTROLLING OSMOTIC SENSITIVITY

Genetics ◽  
1978 ◽  
Vol 89 (4) ◽  
pp. 653-665
Author(s):  
Arjun Singh ◽  
Fred Sherman
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cytochrome C ◽  
Uv Light ◽  
Yeast Saccharomyces Cerevisiae ◽  
Osmotic Sensitivity ◽  
Inhibition Of Growth

ABSTRACT Some of the deletions in the yeast Saccharomyces cerevisiae that encompass the CYC1 gene, which determines iso-1-cytochrome c, extend into the OSM1 gene, causing inhibition of growth on hypertonic media, and into the RAD7 gene, causing sensitivity to UV light. Two deletions (cyc1-363 and cyc1-367) encompass only the CYC1 gene, two deletions (cyc1-366 and cyc1-368) encompass the CYC1 and OSM1 genes, three deletions (cyc1-1, cyc1-364 and cyc1-365) encompass the CYC1, OSM1 and RAD7 genes, while none of the deletions extend into the closely linked SUP4 gene.

Global regulation of mitochondrial biogenesis in Saccharomyces cerevisiae: ABF1 and CPF1 play opposite roles in regulating expression of the QCR8 gene, which encodes subunit VIII of the mitochondrial ubiquinol-cytochrome c oxidoreductase

1992 ◽  
Vol 12 (6) ◽  
pp. 2872-2883
Author(s):  
J H de Winde ◽  
L A Grivell
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cytochrome C ◽  
Mitochondrial Biogenesis ◽  
Binding Sites ◽  
Promoter Region ◽  
S Phase ◽  
Negative Regulator ◽  
Global Regulation ◽  
Two Factors ◽  
Efficient Induction

The multifunctional DNA-binding proteins ABF1 and CPF1 bind in a mutually exclusive manner to the promoter region of the QCR8 gene, which encodes 11-kDa subunit VIII of the Saccharomyces cerevisiae mitochondrial ubiquinol-cytochrome c oxidoreductase (QCR). We investigated the roles that the two factors play in transcriptional regulation of this gene. To this end, the overlapping binding sites for ABF1 and CPF1 were mutated and placed in the chromosomal context of the QCR8 promoter. The effects on transcription of the QCR8 gene were analyzed both under steady-state conditions and during nutritional shifts. We found that ABF1 is required for repressed and derepressed transcription levels and for efficient induction of transcription upon escape from catabolite repression, independently of DNA replication. CPF1 acts as a negative regulator, modulating the overall induction response. Alleviation of repression through CPF1 requires passage through the S phase. Implications of these findings for the roles played by ABF1 and CPF1 in global regulation of mitochondrial biogenesis are discussed.

Cytochrome c Trp65Ser substitution results in inhibition of acetic acid-induced programmed cell death in Saccharomyces cerevisiae

Mitochondrion ◽  
2011 ◽  
Vol 11 (6) ◽  
pp. 987-991 ◽  
Author(s):  
Nicoletta Guaragnella ◽  
Salvatore Passarella ◽  
Ersilia Marra ◽  
Sergio Giannattasio
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Death ◽  
Acetic Acid ◽  
Cytochrome C ◽  
Programmed Cell Death

Evolution of moonlighting proteins: insight from yeasts

2014 ◽  
Vol 42 (6) ◽  
pp. 1715-1719 ◽  
Author(s):  
Carlos Gancedo ◽  
Carmen-Lisset Flores ◽  
Juana M. Gancedo
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Present Article ◽  
Catabolite Repression ◽  
Kluyveromyces Lactis ◽  
Approaches To Studying ◽  
Moonlighting Proteins ◽  
Experimental Approaches ◽  
Gal Genes

The present article addresses the possibilities offered by yeasts to study the problem of the evolution of moonlighting proteins. It focuses on data available on hexokinase from Saccharomyces cerevisiae that moonlights in catabolite repression and on galactokinase from Kluyveromyces lactis that moonlights controlling the induction of the GAL genes. Possible experimental approaches to studying the evolution of moonlighting hexose kinases are suggested.

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