scholarly journals HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene

1998 ◽  
Vol 26 (17) ◽  
pp. 3971-3976 ◽  
Author(s):  
C. Udell
Keyword(s):  
Cell Cycle ◽  
Fission Yeast ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Control Gene ◽  
Cycle Checkpoint

Human and Mouse Homologs of theSchizosaccharomyces pombe rad17+Cell Cycle Checkpoint Control Gene

Genomics ◽  
1999 ◽  
Vol 55 (2) ◽  
pp. 219-228 ◽  
Author(s):  
Hans A.R. Bluyssen ◽  
Nicole C. Naus ◽  
Roselinde I. van Os ◽  
Iris Jaspers ◽  
Jan H.J. Hoeijmakers ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Control Gene ◽  
Cycle Checkpoint ◽  
Human And Mouse

A Human and Mouse Homolog of theSchizosaccharomyces pombe rad1+Cell Cycle Checkpoint Control Gene

Genomics ◽  
1998 ◽  
Vol 54 (2) ◽  
pp. 331-337 ◽  
Author(s):  
Hans A.R. Bluyssen ◽  
Roselinde I. van Os ◽  
Nicole C. Naus ◽  
Iris Jaspers ◽  
Jan H.J. Hoeijmakers ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Control Gene ◽  
Mouse Homolog ◽  
Cycle Checkpoint ◽  
Human And Mouse

DNA damage checkpoint kinases in cancer

2020 ◽  
Vol 22 ◽  
Author(s):  
Hannah L. Smith ◽  
Harriet Southgate ◽  
Deborah A. Tweddle ◽  
Nicola J. Curtin
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Environmental Dna ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Control ◽  
Integrated Network ◽  
Checkpoint Kinases ◽  
G1 Checkpoint ◽  
Cycle Checkpoint ◽  
High Level

Abstract DNA damage response (DDR) pathway prevents high level endogenous and environmental DNA damage being replicated and passed on to the next generation of cells via an orchestrated and integrated network of cell cycle checkpoint signalling and DNA repair pathways. Depending on the type of damage, and where in the cell cycle it occurs different pathways are involved, with the ATM-CHK2-p53 pathway controlling the G1 checkpoint or ATR-CHK1-Wee1 pathway controlling the S and G2/M checkpoints. Loss of G1 checkpoint control is common in cancer through TP53, ATM mutations, Rb loss or cyclin E overexpression, providing a stronger rationale for targeting the S/G2 checkpoints. This review will focus on the ATM-CHK2-p53-p21 pathway and the ATR-CHK1-WEE1 pathway and ongoing efforts to target these pathways for patient benefit.

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