scholarly journals DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining

2004 ◽  
Vol 32 (17) ◽  
pp. 5249-5259 ◽  
Author(s):  
J. Bentley
Keyword(s):  
Bladder Cancer ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Human Bladder Cancer ◽  
End Joining ◽  
Human Bladder ◽  
Dna Double Strand Break ◽  
Break Repair

scholarly journals Regulation of Error-Prone DNA Double-Strand Break Repair and Its Impact on Genome Evolution

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1657 ◽  
Author(s):  
Terrence Hanscom ◽  
Mitch McVey
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Dna Lesions ◽  
Double Strand Break Repair ◽  
End Joining ◽  
Genetic Changes ◽  
Strand Breaks ◽  
Dna Double Strand Break ◽  
Alternative End Joining ◽  
Break Repair

Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation of the genome. These detrimental outcomes are significant drivers of human diseases, including many cancers. Mutagenic double-strand break repair also facilitates heritable genetic changes that drive organismal adaptation and evolution. In this review, we discuss the mechanisms of various error-prone DNA double-strand break repair processes and the cellular conditions that regulate them, with a focus on alternative end joining. We provide examples that illustrate how mutagenic double-strand break repair drives genome diversity and evolution. Finally, we discuss how error-prone break repair can be crucial to the induction and progression of diseases such as cancer.

scholarly journals Bcl2 Negatively Regulates DNA Double-Strand-Break Repair through a Nonhomologous End-Joining Pathway

2008 ◽  
Vol 29 (4) ◽  
pp. 488-498 ◽  
Author(s):  
Qinhong Wang ◽  
Fengqin Gao ◽  
W. Stratford May ◽  
Yangde Zhang ◽  
Tammy Flagg ◽  
...  
Keyword(s):  
Strand Break ◽  
Double Strand Break ◽  
Nonhomologous End Joining ◽  
Double Strand Break Repair ◽  
End Joining ◽  
Dna Double Strand Break ◽  
Break Repair
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