Statin use is associated with early recovery of kidney injury after vascular surgery and improved long-term outcome

Abstract Acute kidney injury is a common sequela after major burn injury, but only a small proportion of patients need renal replacement therapy. In the majority of patients, need for renal replacement therapy subsides before discharge from the burn center but limited literature exists on long-term outcomes. A few studies report an increased risk for chronic renal failure after burn injury. We investigated the long-term outcome of severely burned patients receiving renal replacement therapy during acute burn injury treatment. Data on 68 severely burned patients who received renal replacement therapy in Helsinki Burn Centre between November 1988 and December 2015 were collected retrospectively. Thirty-two patients survived and remained for follow-up after the primary hospital stay until December 31, 2016. About 56.3% of discharged patients were alive at the end of follow-up. In 81.3% of discharged patients, need for renal replacement therapy subsided before discharge. Two patients received renal replacement therapy for longer than 3 months; however, need for renal replacement therapy subsided in both patients. One patient required dialysis several years later on after the need for renal replacement therapy had subsided. This study showed that long-term need for renal replacement therapy is rare after severe burn injury. In the vast majority of patients, need for renal replacement therapy subsided before discharge from primary care. Acute kidney injury in association with burns is a potential but small risk factor for later worsening of kidney function in fragile individuals.

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Long-Term Outcome of Acute Kidney Injury

Management of Acute Kidney Problems ◽

10.1007/978-3-540-69441-0_27 ◽

2009 ◽

pp. 261-267

Author(s):

Michael Joannidis ◽

Philipp G. H. Metnitz

Keyword(s):

Acute Kidney Injury ◽

Kidney Injury ◽

Term Outcome ◽

Long Term Outcome

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Systematic Strategy of Prophylactic Coronary Angiography Improves Long-Term Outcome After Major Vascular Surgery in Medium- to High-Risk Patients

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2009.05.041 ◽

2009 ◽

Vol 54 (11) ◽

pp. 989-996 ◽

Cited By ~ 94

Author(s):

Mario Monaco ◽

Paolo Stassano ◽

Luigi Di Tommaso ◽

Paolo Pepino ◽

Arturo Giordano ◽

...

Keyword(s):

High Risk ◽

Coronary Angiography ◽

Vascular Surgery ◽

Term Outcome ◽

Long Term Outcome ◽

High Risk Patients ◽

Systematic Strategy ◽

Risk Patients ◽

Major Vascular Surgery

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Long-term Outcome of Patients Treated With Prophylactic Nesiritide for the Prevention of Acute Kidney Injury Following Cardiovascular Surgery

Clinical Cardiology ◽

10.1002/clc.20750 ◽

2010 ◽

Vol 33 (4) ◽

pp. 217-221 ◽

Cited By ~ 11

Author(s):

Vijaykumar Lingegowda ◽

Quoc C. Van ◽

Michiko Shimada ◽

Thomas M. Beaver ◽

Bhagwan Dass ◽

...

Keyword(s):

Acute Kidney Injury ◽

Cardiovascular Surgery ◽

Kidney Injury ◽

Term Outcome ◽

Long Term Outcome

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Long-Term Outcome of Prophylactic Coronary Revascularization in Cardiac High-Risk Patients Undergoing Major Vascular Surgery (from the Randomized DECREASE-V Pilot Study)

Yearbook of Surgery ◽

10.1016/s0090-3671(10)79846-3 ◽

2010 ◽

Vol 2010 ◽

pp. 394-395

Author(s):

T.S. Huber

Keyword(s):

Pilot Study ◽

High Risk ◽

Vascular Surgery ◽

Coronary Revascularization ◽

Term Outcome ◽

Long Term Outcome ◽

High Risk Patients ◽

Risk Patients ◽

Major Vascular Surgery

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Association between statin use and clinical course, microbiologic characteristics, and long-term outcome of early Lyme borreliosis. A post hoc analysis of prospective clinical trials of adult patients with erythema migrans

PLoS ONE ◽

10.1371/journal.pone.0261194 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0261194

Author(s):

Daša Stupica ◽

Fajko F. Bajrović ◽

Rok Blagus ◽

Tjaša Cerar Kišek ◽

Stefan Collinet-Adler ◽

...

Keyword(s):

Clinical Trials ◽

Lyme Borreliosis ◽

Erythema Migrans ◽

Term Outcome ◽

Long Term Outcome ◽

Post Hoc Analysis ◽

Associated Symptoms ◽

Post Hoc ◽

Statin Use

Background Statins were shown to inhibit borrelial growth in vitro and promote clearance of spirochetes in a murine model of Lyme borreliosis (LB). We investigated the impact of statin use in patients with early LB. Methods In this post-hoc analysis, the association between statin use and clinical and microbiologic characteristics was investigated in 1520 adult patients with early LB manifesting as erythema migrans (EM), enrolled prospectively in several clinical trials between June 2006 and October 2019 at a single-center university hospital. Patients were assessed at enrollment and followed for 12 months. Results Statin users were older than patients not using statins, but statin use was not associated with Borrelia seropositivity rate, Borrelia skin culture positivity rate, or disease severity as assessed by erythema size or the presence of LB-associated symptoms. The time to resolution of EM was comparable in both groups. The odds for incomplete recovery decreased with time from enrollment, were higher in women, in patients with multiple EM, and in those reporting LB-associated symptoms at enrollment, but were unaffected by statin use. Conclusion Statin use was not associated with clinical and microbiologic characteristics or long-term outcome in early LB.

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