scholarly journals Peroxisome proliferator-activated receptor alpha plays a crucial role in L-carnitine anti-apoptosis effect in renal tubular cells

2009 ◽  
Vol 24 (10) ◽  
pp. 3042-3049 ◽  
Author(s):  
H.-H. Chen ◽  
Y.-M. Sue ◽  
C.-H. Chen ◽  
Y.-H. Hsu ◽  
C.-C. Hou ◽  
...  
Keyword(s):  
Crucial Role ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Tubular Cells ◽  
Receptor Alpha ◽  
Renal Tubular Cells ◽  
Renal Tubular

scholarly journals Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice

2015 ◽  
Vol 4 (7) ◽  
pp. 528-536 ◽  
Author(s):  
Giuseppe D'Agostino ◽  
Claudia Cristiano ◽  
David J. Lyons ◽  
Rita Citraro ◽  
Emilio Russo ◽  
...  
Keyword(s):  
Cognitive Flexibility ◽  
Crucial Role ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Receptor Alpha

scholarly journals Nox4 has a crucial role in uric acid-induced oxidative stress and apoptosis in renal tubular cells

2016 ◽  
Vol 13 (5) ◽  
pp. 4343-4348 ◽  
Author(s):  
Zhuohang Li ◽  
Yiyu Sheng ◽  
Cheng Liu ◽  
Kuiqing Li ◽  
Xin Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Crucial Role ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Renal Tubular

scholarly journals High Glucose Promotes CD36 Expression by Upregulating Peroxisome Proliferator-Activated Receptor γ Levels to Exacerbate Lipid Deposition in Renal Tubular Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Lei Feng ◽  
Chengwu Gu ◽  
Yanxia Li ◽  
Jiasui Huang
Keyword(s):  
Signaling Pathway ◽  
High Glucose ◽  
Peroxisome Proliferator ◽  
Lipid Deposition ◽  
Peroxisome Proliferator Activated Receptor ◽  
Diabetic Kidney ◽  
Beneficial Effects ◽  
Renal Tubular Cells ◽  
Cd36 Expression ◽  
Renal Tubular

Diabetic kidney disease (DKD) appears to be closely related to lipid deposition in kidney. The aim of this study was to determine whether high glucose (HG) exacerbated lipid deposition by increasing CD36 expression via AKT-PPARγ signaling pathway. Our results showed that HG activated AKT signaling pathway, followed by an increase in PPARγ that induced CD36 overexpression, ultimately causing lipid deposition in HK-2 cells. We also found that inhibition of AKT-PPARγ signaling pathway or knockdown of CD36 could reduce HG-induced lipid accumulation in HK-2 cells. These results indicated that AKT-PPARγ signaling pathway mediated HG-induced lipid deposition by upregulating CD36 expression in HK-2 cells and that inhibition of AKT-PPARγ signaling pathway had the potential beneficial effects of reducing lipid deposition in diabetic kidney.

scholarly journals Human antigen R regulates hypoxia‐induced mitophagy in renal tubular cells through PARKIN/BNIP3L expressions

2021 ◽  
Author(s):  
Shao‐Hua Yu ◽  
Kalaiselvi Palanisamy ◽  
Kuo‐Ting Sun ◽  
Xin Li ◽  
Yao‐Ming Wang ◽  
...  
Keyword(s):  
Tubular Cells ◽  
Human Antigen R ◽  
Renal Tubular Cells ◽  
Renal Tubular
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