scholarly journals Aliskiren reduces sympathetic nerve activity and blood pressure in chronic kidney disease patients

2011 ◽  
Vol 26 (9) ◽  
pp. 2930-2934 ◽  
Author(s):  
L. Siddiqi ◽  
P. L. Oey ◽  
P. J. Blankestijn
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity

scholarly journals Effect of renal ablation on blood pressure and muscle sympathetic nerve activity in chronic kidney disease patients (LB722)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Genevieve Wilson ◽  
Neil Hoye ◽  
Luke Wilson ◽  
J, Kevin Shoemaker ◽  
Rob Walker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Renal Ablation

scholarly journals Nocturnal blood pressure is associated with sympathetic nerve activity in patients with chronic kidney disease

2020 ◽  
Vol 8 (20) ◽  
Author(s):  
Jin H. Jeong ◽  
Ida T. Fonkoue ◽  
Arshed A. Quyyumi ◽  
Dana DaCosta ◽  
Jeanie Park
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Nocturnal Blood Pressure

Effects of an SGLT2 inhibitor on the salt sensitivity of blood pressure and sympathetic nerve activity in a nondiabetic rat model of chronic kidney disease

2020 ◽  
Vol 43 (6) ◽  
pp. 492-499 ◽  
Author(s):  
Ningning Wan ◽  
Yoshihide Fujisawa ◽  
Hideki Kobara ◽  
Tsutomu Masaki ◽  
Daisuke Nakano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Rat Model ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Sglt2 Inhibitor ◽  
Salt Sensitivity ◽  
Nerve Activity

scholarly journals Augmented Respiratory–Sympathetic Coupling and Hemodynamic Response to Acute Mild Hypoxia in Female Rodents With Chronic Kidney Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Manash Saha ◽  
Qi-Jian Sun ◽  
Cara M. Hildreth ◽  
Peter G. R. Burke ◽  
Jacqueline K. Phillips
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Acute Hypoxia ◽  
Area Under The Curve ◽  
Female Rats ◽  
Nerve Activity ◽  
Mild Hypoxia

Carotid body feedback and hypoxia may serve to enhance respiratory–sympathetic nerve coupling (respSNA) and act as a driver of increased blood pressure. Using the Lewis polycystic kidney (LPK) rat model of chronic kidney disease, we examined respSNA in adult female rodents with CKD and their response to acute hypoxia or hypercapnia compared to Lewis control animals. Under urethane anesthesia, phrenic nerve activity, splanchnic sympathetic nerve activity (sSNA), and renal sympathetic nerve activity (rSNA) were recorded under baseline conditions and during mild hypoxic or hypercapnic challenges. At baseline, tonic SNA and blood pressure were greater in female LPK rats versus Lewis rats (all P < 0.05) and respSNA was at least two-fold larger [area under the curve (AUC), sSNA: 7.8 ± 1.1 vs. 3.4 ± 0.7 μV s, rSNA: 11.5 ± 3 vs. 4.8 ± 0.7 μV s, LPK vs. Lewis, both P < 0.05]. Mild hypoxia produced a larger pressure response in LPK [Δ mean arterial pressure (MAP) 30 ± 6 vs. 12 ± 6 mmHg] and augmented respSNA (ΔAUC, sSNA: 8.9 ± 3.4 vs. 2 ± 0.7 μV s, rSNA: 6.1 ± 1.2 vs. 3.1 ± 0.7 μV s, LPK vs. Lewis, all P ≤ 0.05). In contrast, central chemoreceptor stimulation produced comparable changes in blood pressure and respSNA (ΔMAP 13 ± 3 vs. 9 ± 5 mmHg; respSNA ΔAUC, sSNA: 2.5 ± 1 vs. 1.3 ± 0.7 μV s, rSNA: 4.2 ± 0.9 vs. 3.5 ± 1.4 μV s, LPK vs. Lewis, all P > 0.05). These results demonstrate that female rats with CKD exhibit heightened respSNA coupling at baseline that is further augmented by mild hypoxia, and not by hypercapnia. This mechanism may be a contributing driver of hypertension in this animal model of CKD.

The effect of losartan on differential reflex control of sympathetic nerve activity in chronic kidney disease

2015 ◽  
Vol 33 (6) ◽  
pp. 1249-1260 ◽  
Author(s):  
Yimin Yao ◽  
Cara M. Hildreth ◽  
Melissa M. Farnham ◽  
Manash Saha ◽  
Qi-Jian Sun ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Reflex Control

ALISKIREN REDUCES SYMPATHETIC NERVE ACTIVITY IN CHRONIC KIDNEY DISEASE PATIENTS: PP.24.467

2010 ◽  
Vol 28 ◽  
pp. e386
Author(s):  
L Siddiqi ◽  
PL Oey ◽  
PJ Blankestijn
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity

scholarly journals Mindfulness meditation lowers muscle sympathetic nerve activity and blood pressure in African-American males with chronic kidney disease

2014 ◽  
Vol 307 (1) ◽  
pp. R93-R101 ◽  
Author(s):  
Jeanie Park ◽  
Robert H. Lyles ◽  
Susan Bauer-Wu
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
African American ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Mindfulness Meditation ◽  
Muscle Sympathetic Nerve Activity ◽  
Hemodynamic Changes ◽  
Nerve Activity ◽  
Control Intervention

Mindfulness meditation (MM) is a stress-reduction technique that may have real biological effects on hemodynamics but has never previously been tested in chronic kidney disease (CKD) patients. In addition, the mechanisms underlying the potential blood pressure (BP)-lowering effects of MM are unknown. We sought to determine whether MM acutely lowers BP in CKD patients, and whether these hemodynamic changes are mediated by a reduction in sympathetic nerve activity. In 15 hypertensive African-American (AA) males with CKD, we conducted a randomized, crossover study in which participants underwent 14 min of MM or 14 min of BP education (control intervention) during two separate random-order study visits. Muscle sympathetic nerve activity (MSNA), beat-to-beat arterial BP, heart rate (HR), and respiratory rate (RR) were continuously measured at baseline and during each intervention. A subset had a third study visit to undergo controlled breathing (CB) to determine whether a reduction in RR alone was sufficient in exacting hemodynamic changes. We observed a significantly greater reduction in systolic BP, diastolic BP, mean arterial pressure, and HR, as well as a significantly greater reduction in MSNA, during MM compared with the control intervention. Participants had a significantly lower RR during MM; however, in contrast to MM, CB alone did not reduce BP, HR, or MSNA. MM acutely lowers BP and HR in AA males with hypertensive CKD, and these hemodynamic effects may be mediated by a reduction in sympathetic nerve activity. RR is significantly lower during MM, but CB alone without concomitant meditation does not acutely alter hemodynamics or sympathetic activity in CKD.

scholarly journals Direct conscious telemetry recordings demonstrate increased renal sympathetic nerve activity in rats with chronic kidney disease

2015 ◽  
Vol 6 ◽  
Author(s):  
Ibrahim M. Salman ◽  
Divya Sarma Kandukuri ◽  
Joanne L. Harrison ◽  
Cara M. Hildreth ◽  
Jacqueline K. Phillips
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Renal Sympathetic Nerve Activity ◽  
Renal Sympathetic Nerve ◽  
Renal Sympathetic

scholarly journals Tetrahydrobiopterin lowers muscle sympathetic nerve activity in patients with chronic kidney disease (852.8)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Jeanie Park ◽  
Salman Sher ◽  
Melanie Jefferson ◽  
Arshed Quyyumi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Nerve Activity
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