scholarly journals Monoclonal immunoglobulin G deposits on tubular basement membrane in renal allograft: is this significant for chronic allograft injury?

2018 ◽  
Vol 34 (4) ◽  
pp. 711-717
Author(s):  
Anri Sawada ◽  
Kunio Kawanishi ◽  
Shigeru Horita ◽  
Kazuya Omoto ◽  
Masayoshi Okumi ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Immunoglobulin G ◽  
Renal Allograft ◽  
Tubular Basement Membrane ◽  
Monoclonal Immunoglobulin

scholarly journals Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits complicated by immunoglobulin A nephropathy in the renal allograft

Nephrology ◽  
2016 ◽  
Vol 21 ◽  
pp. 48-52
Author(s):  
Anri Sawada ◽  
Kunio Kawanishi ◽  
Shigeru Horita ◽  
Junki Koike ◽  
Kazuho Honda ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Renal Allograft ◽  
Immunoglobulin A ◽  
Proliferative Glomerulonephritis ◽  
Immunoglobulin A Nephropathy ◽  
Monoclonal Immunoglobulin

Polyclonal immunoglobulin G deposition on the tubular basement membrane in a diabetic nephropathy: A case report

2020 ◽  
Vol 70 (7) ◽  
pp. 463-469
Author(s):  
Hirofumi Watanabe ◽  
Yoichi Takeuchi ◽  
Shinji Taniuchi ◽  
Hiroshi Sato ◽  
Yasuhiro Nakamura ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Case Report ◽  
Basement Membrane ◽  
Immunoglobulin G ◽  
Tubular Basement Membrane ◽  
Polyclonal Immunoglobulin

ANTI-TUBULAR BASEMENT MEMBRANE ANTIBODIES AND GIANT CELL FORMATION IN A MODEL OF CHRONIC RENAL ALLOGRAFT REJECTION

2004 ◽  
Vol 77 (8) ◽  
pp. 1295-1297 ◽  
Author(s):  
Simone A. Joosten ◽  
Hallgrimur Benediktsson ◽  
Maria C. Borrias ◽  
Vanessa van Ham ◽  
Mieneke G. A. van Dixhoorn ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Giant Cell ◽  
Allograft Rejection ◽  
Renal Allograft ◽  
Cell Formation ◽  
Tubular Basement Membrane ◽  
Renal Allograft Rejection ◽  
Giant Cell Formation

Effects of Concentration-Polarization on the Filtration of Proteins through Filters Constructed from Isolated Renal Basement Membrane

1978 ◽  
Vol 55 (1) ◽  
pp. 113-119
Author(s):  
T. G. Cotter ◽  
G. B. Robinson
Keyword(s):  
Bovine Serum Albumin ◽  
Basement Membrane ◽  
Immunoglobulin G ◽  
Bovine Serum ◽  
Concentration Polarization ◽  
Hydraulic Permeability ◽  
Tubular Basement Membrane ◽  
Membrane Filters ◽  
Renal Tubular

1. Filters comprising multiple layers of rabbit renal tubular basement membrane were constructed with conventional pressure filtration chambers. The effects of concentration-polarization on the behaviour of these filters was assessed by studying the filtration of proteins and of serum under turbulent (stirred) and unstirred conditions. 2. With stirring bovine serum albumin was effectively rejected by the filter barriers (σ = 0.95) but rejection was diminished (σ = 0.18) without stirring. The hydraulic permeability of the filters also fell without stirring. 3. In the presence of horse immunoglobulin G, a wholly rejected protein, the rejection of cytochrome c was increased and hydraulic flux was reduced. 4. Filtration studies of serum showed that serum protein was effectively rejected with stirring (σ > 0.999) but rejection diminished when stirring ceased (σ = 0.98). Albumin was the only protein detected in the filtrate with stirring but α- and β-globulins appeared when stirring ceased. 5. These results show that concentration-polarization markedly affects the behaviour of these basement membrane filters in vitro, since without stirring a polarization layer of rejected protein is formed, which reduces hydraulic permeability and results in increased protein permeation through the filter.

Ultrastructural evidence of transplacental transport of immunoglobulin G in bitches

Reproduction ◽  
2000 ◽  
pp. 315-326 ◽  
Author(s):  
MH Stoffel ◽  
AE Friess ◽  
SH Hartmann
Keyword(s):  
Mammary Gland ◽  
Basement Membrane ◽  
Immunoglobulin G ◽  
Passive Immunity ◽  
Morphological Evidence ◽  
Membrane Material ◽  
Ultrastructural Evidence ◽  
Cytotrophoblast Cells ◽  
Fetal Vessels

In dogs, passive immunity is conferred to fetuses and neonates by the transfer of maternal immunoglobulin G through the placenta during the last trimester of pregnancy and via the mammary gland after parturition, respectively. However, morphological evidence of transplacental transport is still lacking. The aim of the present study was to localize maternal immunoglobulin G in the labyrinthine zone and in the haemophagous zone of the canine placenta by means of immunohistochemistry and immunocytochemistry. In the labyrinthine zone, immunoglobulin G was detected in all the layers of the materno-fetal barrier including the fetal capillaries. Immunoreactivity was particularly prominent in maternal basement membrane material as well as in the syncytiotrophoblast. However, this evidence of transplacental transport of immunoglobulin G originated from a limited number of unevenly distributed maternal vessels only. In the cytotrophoblast of the haemophagous zone, immunoglobulin G was localized to phagolysosomes at various stages but was never detected within fetal vessels. The results indicate that maternal immunoglobulin G is degraded in cytotrophoblast cells of the hemophagous zone and, therefore, that transplacental transport is restricted to a subpopulation of maternal vessels in the labyrinthine zone.

scholarly journals Renal calcitonin receptors and adenylate cyclase in rats immunized against tubular basement membrane

1977 ◽  
Vol 12 (3) ◽  
pp. 184-192 ◽  
Author(s):  
Nadine Loreau ◽  
Jean-Pierre Cosyns ◽  
Chantal Lepreux ◽  
Pierre Verroust ◽  
Raymond Ardaillou
Keyword(s):  
Basement Membrane ◽  
Adenylate Cyclase ◽  
Tubular Basement Membrane ◽  
Calcitonin Receptors

scholarly journals Die Kaliumhydrogenphosphat-induzierte Nephropathie des Hundes. I. Pathogenese der Tubulusatrophiee [Potassium Hydrogen Phosphate Induced Nephropathy in the Dog. I. Pathogenesis of Tubular Atrophy—author's trans.]

1980 ◽  
Vol 17 (6) ◽  
pp. 699-719 ◽  
Author(s):  
P. Schneider ◽  
G. Pappritz ◽  
R. Müller-Peddinghaus ◽  
M. Bauer ◽  
H. Lehmann ◽  
...  
Keyword(s):  
Acid Phosphatase ◽  
Epithelial Cells ◽  
Basement Membrane ◽  
Basement Membranes ◽  
Tubular Epithelial Cells ◽  
Beagle Dogs ◽  
Lysosomal Degradation ◽  
Tubular Basement Membrane ◽  
Tubular Atrophy ◽  
Study Results

A nephropathy with severe tubular atrophy was observed in Beagle dogs after oral administration of K2HPO4 for 14 or 38 weeks. We describe the complete lysosomal degradation of atrophying tubular epithelial cells. During two experiments of 14 and 38 weeks duration, respectively, a total of 15 Beagle dogs received 0.8 g K2HPO4/kg body weight daily with their food. All dogs were examined clinically at regular intervals. Renal biopsies were taken in the fourth week from beagles of the 14-week study. Results were compared with those of control dogs. At the end of the experiments the animals were killed and necropsies done. Different stains and histochemical reactions were applied to paraffin sections of the kidneys. Acid phosphatase and β-glucuronidase were found on cryostat sections. Kidneys fixed by perfusion of five Beagles from the 38-week study and three Beagles of the 14-week study, and from five control dogs, were examined electron microscopically. Ultrahistochemically, acid phosphatase was demonstrated. Clinically, the dogs in both experiments vomited, were cachectic, and had elevated creatinine and blood urea nitrogen. Morphologically, qualitatively identical changes were seen, but the renal damage was most marked at 38 weeks. There were disseminated tubular atrophy (usually of the proximal tubules), focal scar tissue and nephrocalcinosis. The following pathogenesis was established for the lesions of the proximal tubule: Tubular atrophy begins with loss of differentiation of epithelial cells. Enzyme histochemistry, ultrahistochemistry and electron microscopy show an increase in autophagic vacuoles and autophagolysosomes. The lysosomal bodies showing fusion enclose large parts of the cytoplasm as the process continues. Complete lysosomal degradation of epithelial cells and extrusion of large lysosomes into the tubular lumen follow. After complete enzymatic digestion of the intratubular detritus, the residue is empty, convoluted and collapsed tubular basement membrane. Atrophic tubular epithelial cells have many organelle-free zones at their base, which contain fine filamentous material resembling that of the basement membrane. The degradation processes described here may explain why clinically the urinary sediment contains few cylinders and epithelial cells and why proteinuria decreases significantly toward the end of the experiment. So far, it is not clear whether the tubular basement membrane is synthesized by the tubular cells, by fibroblasts or by both cell types. The presence of basement membrane-like material in tubular epithelial cells and in parietal epithelial cells of the glomerulus favors the view that epithelial cells produce the basement membranes and that increased production of basement membrane-like material is a sign of loss of differentiation.

Performance evaluation of Mimetic Ligand™ B14-triazole-FractoAIMs adsorbents for the capture of human monoclonal immunoglobulin G from cell culture feed

2010 ◽  
Vol 400 (8) ◽  
pp. 2349-2359 ◽  
Author(s):  
Jeannie Horak ◽  
Stefan Hofer ◽  
Chris Sadler ◽  
Sharon Williams ◽  
Wolfgang Lindner
Keyword(s):  
Cell Culture ◽  
Performance Evaluation ◽  
Immunoglobulin G ◽  
Monoclonal Immunoglobulin
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