In reply to the letter to the editor regarding “Cognitive outcomes in meningioma patients undergoing surgery: individual changes over time and predictors of late cognitive functioning”

Caffeine and diphenhydramine are known to affect cognitive functioning in vigilance tasks. In this study, long-latency auditory evoked potentials (AEPs) obtained during concomitant performance of a visual vigilance task were examined for changes in response to administration of caffeine (200 mg) and diphenhydramine (25 mg). The AEPs were also analyzed for changes over time for up to two hours postdrug administration. Significant increases in N1 and P2 latencies and decreases in amplitude voltage were exhibited over time. The P2-N2 amplitude was significantly lower throughout testing after taking caffeine. A significant increase was seen in the P2-N2 amplitude 40 min. after diphenhydramine ingestion. These changes in amplitude may be the result of the auditory stimulus acting as a diversion to the participants while performing the visual vigilance task. Diphenhydramine was more likely to impair participants' vigilance, resulting in greater attention paid toward the auditory stimulus, whereas caffeine seemed to help participants maintain their focus of attention on the visual vigilance task.

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Cognitive outcomes in meningioma patients undergoing surgery: individual changes over time and predictors of late cognitive functioning

Neuro-Oncology ◽

10.1093/neuonc/noz039 ◽

2019 ◽

Vol 21 (7) ◽

pp. 911-922 ◽

Cited By ~ 9

Author(s):

Sophie J M Rijnen ◽

Ikram Meskal ◽

Marjan Bakker ◽

Wouter De Baene ◽

Geert-Jan M Rutten ◽

...

Keyword(s):

Cognitive Functioning ◽

Cognitive Performance ◽

Cognitive Deficits ◽

Cognitive Rehabilitation ◽

Cognitive Outcomes ◽

Cognitive Outcome ◽

Normative Sample ◽

Before And After ◽

Preoperative Predictors ◽

Over Time

Abstract Background Meningioma patients are known to face cognitive deficits before and after surgery. We examined individual changes in cognitive performance over time and identified preoperative predictors of cognitive functioning 12 months after surgery in a large sample of meningioma patients. Methods Patients underwent neuropsychological assessment (NPA) using CNS Vital Signs 1 day before (T0) and 3 (T3) and 12 (T12) months after surgery. Patients’ sociodemographically corrected scores on 7 cognitive domains were compared with performance of a normative sample using one-sample z tests and chi-square tests of independence. Reliable change indices with correction for practice effects were calculated for individual patients. Linear mixed effects models were used to identify preoperative predictors of performance at T12. Results At T0, 261 patients were assessed, and 229 and 82 patients were retested at T3 and T12, respectively. Patients showed impaired cognitive performance before and after surgery, and although performance improved on the group level, cognitive scores remained significantly lower than in the normative sample up to T12. On the individual level, performance remained stable in the majority of patients. Better preoperative performance, younger age, male sex, and higher educational level predicted better late cognitive performance. Conclusions Meningioma patients face serious and persistent pre- and postsurgical cognitive deficits. A preoperative NPA together with sociodemographic characteristics may provide valuable information on the late cognitive outcome of individual meningioma patients. These results can help to inform patients and clinicians on late cognitive outcomes at an early stage, and emphasizes the importance of presurgical NPA and timely cognitive rehabilitation.

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The course of cognitive functioning in first episode psychosis: Changes over time and impact on outcome

Schizophrenia Research ◽

10.1016/j.schres.2005.05.008 ◽

2005 ◽

Vol 78 (1) ◽

pp. 35-43 ◽

Cited By ~ 101

Author(s):

Jean Addington ◽

Huma Saeedi ◽

Donald Addington

Keyword(s):

Cognitive Functioning ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

Changes Over Time ◽

Over Time

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Comparison of two devices for measuring exercise transcutaneous oxygen pressures in patients with claudication

VASA ◽

10.1024/0301-1526/a000454 ◽

2015 ◽

Vol 44 (5) ◽

pp. 355-362 ◽

Cited By ~ 8

Author(s):

Marie Urban ◽

Alban Fouasson-Chailloux ◽

Isabelle Signolet ◽

Christophe Colas Ribas ◽

Mathieu Feuilloy ◽

...

Keyword(s):

Oxygen Pressure ◽

Optical Sensors ◽

Chemical Sensors ◽

Transcutaneous Oxygen ◽

Starting Values ◽

Two Systems ◽

Transcutaneous Oxygen Pressure ◽

New Sensors ◽

Changes Over Time ◽

Over Time

Abstract. Summary: Background: We aimed at estimating the agreement between the Medicap® (photo-optical) and Radiometer® (electro-chemical) sensors during exercise transcutaneous oxygen pressure (tcpO2) tests. Our hypothesis was that although absolute starting values (tcpO2rest: mean over 2 minutes) might be different, tcpO2-changes over time and the minimal value of the decrease from rest of oxygen pressure (DROPmin) results at exercise shall be concordant between the two systems. Patients and methods: Forty seven patients with arterial claudication (65 + / - 7 years) performed a treadmill test with 5 probes each of the electro-chemical and photo-optical devices simultaneously, one of each system on the chest, on each buttock and on each calf. Results: Seventeen Medicap® probes disconnected during the tests. tcpO2rest and DROPmin values were higher with Medicap® than with Radiometer®, by 13.7 + / - 17.1 mm Hg and 3.4 + / - 11.7 mm Hg, respectively. Despite the differences in absolute starting values, changes over time were similar between the two systems. The concordance between the two systems was approximately 70 % for classification of test results from DROPmin. Conclusions: Photo-optical sensors are promising alternatives to electro-chemical sensors for exercise oximetry, provided that miniaturisation and weight reduction of the new sensors are possible.

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