scholarly journals OTHR-02. MULTIMODALITY TREATMENT FOR CHILDREN WITH CENTRAL NERVOUS SYSTEM (CNS) TUMOR IN OUR INSTITUTE

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii423-iii423
Author(s):  
Mari Sasano ◽  
Koichiro Sumi ◽  
Nobuhiro Moro ◽  
Hideki Oshima ◽  
Maiko Hirai ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Malignant Tumors ◽  
Treatment Plan ◽  
Pediatric Brain Tumor ◽  
Multimodality Treatment ◽  
Whole Body ◽  
Cell Transplant ◽  
Treatment Team ◽  
Cns Tumor

Abstract BACKGROUND The brain tumor has a highest mortality rate among childhood malignant tumors. Development of peripheral blood stem cell transplant combined chemotherapy and radiation therapy improved the survival rate of patients with pediatric brain tumor drastically late years. Because of its complicated treatment plan, neurosurgeons cannot readily manage these aggressive therapies which require minute whole body control including prevention of lethal infection due to bone marrow suppression. Even if such treatment is effective and patient survives, the aftereffects may reduce patient’s QOL. PURPOSE We report outcomes of the patients with CNS tumor after multimodality treatment. In addition, we introduce the activity contents by the in-hospital children brain tumor multi-disciplinary medical treatment team organized in March 2016. METHODS We retrospectively reviewed 29 patients (under 15 years old) diagnosed as CNS tumors with total of 43 tumor surgeries between January 2001 and December 2019. RESULTS The histopathological diagnoses were 7 germ cell tumor, 7 astrocytic tumor, 4 ependymal tumor, 4 medulloblastoma, 2 craniopharyngioma, 2 AT/RT and 3 others. The mean age at first surgery was 7.4 y.o. (range: 0.3–14.8). Both chemotherapy and radiation therapy were performed in 22 cases out of 29. There were 15 survivors (11 ambulant, 3 W/C, 1 bedridden), 12 deaths, 2 lost follow-ups. Mean follow-up period was 66 months (range: 1–206). CONCLUSION To improve outcomes, we hold on a regular basis of team meeting, discuss treatment plan, and share information. Recently, we also care issues of the patients, such as fertility and palliative medicine.

scholarly journals TR-04 * NANOPARTICLE siRNA DELIVERY VEHICLES INHIBIT DNA REPAIR AND SENSITIZE PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY

2015 ◽  
Vol 17 (suppl 3) ◽  
pp. iii37-iii37
Author(s):  
F. Kievit ◽  
Z. Stephen ◽  
K. Wang ◽  
C. Dayringer ◽  
J. Silber ◽  
...  
Keyword(s):  
Dna Repair ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Sirna Delivery ◽  
Pediatric Brain Tumor ◽  
Brain Tumor Cells ◽  
Delivery Vehicles ◽  
Pediatric Brain

scholarly journals Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors

2018 ◽  
Vol 33 (5) ◽  
pp. 359-366 ◽  
Author(s):  
Matthew Nordstrom ◽  
Erin Felton ◽  
Katherine Sear ◽  
Benita Tamrazi ◽  
Joseph Torkildson ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Pediatric Brain Tumor ◽  
Childhood Cancer Survivors ◽  
Large Vessel ◽  
Arterial Ischemic Stroke ◽  
Cranial Radiation ◽  
Radiation Induced ◽  
Cerebral Arteriopathy ◽  
Pediatric Brain

Among childhood cancer survivors, increased stroke risk after cranial radiation therapy may be caused by radiation-induced arteriopathy, but limited data exist to support this hypothesis. Herein, we assess the timing and presence of cerebral arteriopathy identified by magnetic resonance angiography (MRA) after cranial radiation therapy in childhood brain tumor survivors. In a cohort of 115 pediatric brain tumor survivors, we performed chart abstraction and prospective annual follow-up to assess the presence of large vessel cerebral arteriopathy by MRA. We identified 10 patients with cerebral arteriopathy. The cumulative incidence of arteriopathy 5 years post–cranial radiation therapy was 5.4% (CI 0.6%-10%) and 10 years was 16% (CI 4.6%-26%). One patient had an arterial ischemic stroke 2.4 years post–cranial radiation therapy in the distribution of a radiation-induced stenotic artery. We conclude that large vessel arteriopathies can occur within a few years of cranial radiation therapy and can become apparent on MRA in under a year.

scholarly journals Working memory and attention in pediatric brain tumor patients treated with and without radiation therapy

2016 ◽  
Vol 23 (6) ◽  
pp. 642-654 ◽  
Author(s):  
Kimberly P. Raghubar ◽  
E. Mark Mahone ◽  
Keith Owen Yeates ◽  
Kim M. Cecil ◽  
Monwabisi Makola ◽  
...  
Keyword(s):  
Working Memory ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Pediatric Brain Tumor ◽  
Tumor Patients ◽  
Memory And Attention ◽  
Pediatric Brain

scholarly journals NT-16 * NANOPARTICLE-MEDIATED DELIVERY OF ANTI-Ape1 siRNA SENSITIZES PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY BY INHIBITING DNA REPAIR

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v162-v162
Author(s):  
F. Kievit ◽  
Z. Stephen ◽  
K. Wang ◽  
C. Dayringer ◽  
R. Ellenbogen ◽  
...  
Keyword(s):  
Dna Repair ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Pediatric Brain Tumor ◽  
Brain Tumor Cells ◽  
Pediatric Brain

scholarly journals The use of radiation therapy in combination treatment of soft tissue sarcomas of the extremities with involvement of long tubular bones

2021 ◽  
Vol 30 (3) ◽  
pp. 124-133
Author(s):  
A.L. Zubarev ◽  
◽  
A.A. Kurilchik ◽  
V.E. Ivanov ◽  
A.L. Starodubtsev ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Combination Treatment ◽  
Bone Disease ◽  
Malignant Tumors ◽  
Treatment Plan ◽  
Soft Tissue Sarcomas ◽  
Malignant Neoplasms ◽  
Postoperative Radiation Therapy ◽  
Local Hyperthermia

Soft tissue sarcomas (STS) are rare malignant tumors of mesenchymal origin. They account for about 1% of all malignant neoplasms. Haematogenous spread is the most common route of me-tastasis for STS and bone metastases occur in 9.4% of cases. When creating treatment plan for STS, it is necessary to consider a multimodal approach. Combination treatment can include pre-operative or postoperative radiation therapy (RT), chemotherapy (CT), and local hyperthermia (LHT). Surgery for STS should be radical. This paper presents 9 STS clinical cases and treatment outcomes in patients with secondary bone disease. Four patients underwent chemotherapy and surgery. Two patients received chemoradiotherapy (CRT) and surgery. Three patients received thermo-chemo-radiotherapy (TCHRT) followed by surgery. Accelerated fractionation radiotherapy was given using a single tumor dose of 3 Gy, twice a day with interval of 4 hours between ses-sions, 3 times a week to a total tumor dose (TTD) of 30 Gy (isoeffective TTD – 42 Gy, TDF – 69 Gy). Local hyperthermia for soft tissue tumor treatment was performed over 6 sessions: 2 ses-sions were combined with CHT courses before and after RT, and 4 sessions were combined with RT. The follow up period for 6 patients varied from 12 to 1.5 months, for 3 patients it varied from 6 to 8 months, for 1 patient it lasted 3 months and for 1 patient – 2 years. According to the RECIST criteria, more than half of the patients had tumor stabilization and 22% of patients had a partial response. Grade III-IV the rapeutic pathomorphosis was observed in 70% of patients after pre-operative combination treatment. The use of CT, CRT or TCHRT in combination treatment of STS with secondary bone disease enabled us to achieve a pronounced therapeutic pathomorphosis of tumors and to perform organ preservation surgery with endoprosthetic replacement.

scholarly journals The Use of Intraoperative Radiation Therapy (IORT) in Multimodality Management of Cancer Patients. A Single Institution Experience.

2021 ◽  
Author(s):  
Ahmed Elashwah ◽  
Abdullah Alsuhaibani ◽  
Ayman Azzam ◽  
Belal Moftah ◽  
Muhammed Hussein ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Malignant Tumors ◽  
Postoperative Mortality ◽  
Multimodality Treatment ◽  
Treatment Modalities ◽  
Intraoperative Radiation Therapy ◽  
Curative Intent ◽  
Intraoperative Radiation ◽  
Normal Tissues

Abstract Background Intraoperative radiation therapy (IORT) is a highly conformal technique given in the operating room in many cancer sites for better tumor local control by increasing the tumor radiation dose without exceeding normal tissues tolerance doses.Purpose Assess the feasibility of Intra operative radiation therapy (IORT) and short-term toxicity in patients with different cancer sites treated with a multidisciplinary protocols including IORT.Patients & MethodsMedical records of cancer patients who received IORT at King Faisal Specialized Hospital and Research center(KFSHRC), Riyadh, Saudi Arabia from 2013 until 2017 were retrospectively reviewed.ResultsTotal 188 patients with 212 IORT applications were analyzed. Twenty-four patients had more than one application.116 patients were males. Median age at time of diagnosis was 49.5years (19-77). Hundred thirty four patients had primary while 54 cases had recurrent disease. Gastro esophageal cancer and soft tissue sarcoma were the most frequent diagnosis in 49 patients followed by colorectal cancer in 35 patients. Major surgeries with curative intent done in 183 patients (97.3%) and 118 patients (62.8%) had hyperthermic intraperitoneal chemotherapy (HIPEC) in addition to IORT. The 30days postoperative mortality rate was 3.2%. Fifty-three (28.2%) patients develop Grade III-IV complications according to Clavien-Dindo grading system. ConclusionThe data presented discussing treatment modalities for different malignant tumors which are treated and may benefit from using IORT technique as a part of multimodality treatment. IORT seems safe and feasible, however a longer follow-up is needed for proper evaluation and defining the role of IORT in tailored multimodality approach.

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