The Use of Intraoperative Radiation Therapy (IORT) in Multimodality Management of Cancer Patients. A Single Institution Experience.

Background Intraoperative radiation therapy (IORT) is a highly conformal technique given in the operating room in many cancer sites for better tumor local control by increasing the tumor radiation dose without exceeding normal tissues tolerance doses.Purpose Assess the feasibility of Intra operative radiation therapy (IORT) and short-term toxicity in patients with different cancer sites treated with a multidisciplinary protocols including IORT.Patients & MethodsMedical records of cancer patients who received IORT at King Faisal Specialized Hospital and Research center(KFSHRC), Riyadh, Saudi Arabia from 2013 until 2017 were retrospectively reviewed.ResultsTotal 188 patients with 212 IORT applications were analyzed. Twenty-four patients had more than one application.116 patients were males. Median age at time of diagnosis was 49.5years (19-77). Hundred thirty four patients had primary while 54 cases had recurrent disease. Gastro esophageal cancer and soft tissue sarcoma were the most frequent diagnosis in 49 patients followed by colorectal cancer in 35 patients. Major surgeries with curative intent done in 183 patients (97.3%) and 118 patients (62.8%) had hyperthermic intraperitoneal chemotherapy (HIPEC) in addition to IORT. The 30days postoperative mortality rate was 3.2%. Fifty-three (28.2%) patients develop Grade III-IV complications according to Clavien-Dindo grading system. ConclusionThe data presented discussing treatment modalities for different malignant tumors which are treated and may benefit from using IORT technique as a part of multimodality treatment. IORT seems safe and feasible, however a longer follow-up is needed for proper evaluation and defining the role of IORT in tailored multimodality approach.