scholarly journals MPTH-38. TRANSFORMING GROWTH FACTOR-BETA GENE EXPRESSION AS A NEW PROGNOSTIC BIOMARKER FOR GLIOBLASTOMA

2016 ◽  
Vol 18 (suppl_6) ◽  
pp. vi114-vi114
Author(s):  
Laurent-Olivier Roy ◽  
Marie-Belle Poirier ◽  
Marie Blanchette ◽  
David Fortin
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Prognostic Biomarker ◽  
Growth Factor Beta ◽  
Beta Gene

scholarly journals Trastuzumab treatment is associated with elevated transforming growth factor beta gene expression.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Expression Data ◽  
Human Breast ◽  
Trastuzumab Treatment ◽  
Growth Factor Beta ◽  
Beta Gene

The transforming growth factor beta superfamily, as its name implies, is critical for oncogenesis in multiple cellular contexts (1-8). We found, through mining published microarray and multiplexed gene expression data (9-11), that administration of trastuzumab was associated with increased expression of TGFBR1 and TGFBI. These data serve as one piece of evidence arguing against the use of trastuzumab in human breast cancer, a patient population already prone to difficult-to-treat metastases (12-15).

Procollagen Types I and III and Transforming Growth Factor-Beta Gene Expression in the Arterial Wall after Exposure to Periarterial Blood

Neurosurgery ◽  
1993 ◽  
Vol 33 (4) ◽  
pp. 716-722 ◽  
Author(s):  
Hidetoshi Kasuya ◽  
Bryce Weir ◽  
Youjun Shen ◽  
Gregory Hariton ◽  
Bozena Vollrath ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Arterial Wall ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Beta Gene

Procollagen Types I and III and Transforming Growth Factor-Beta Gene Expression in the Arterial Wall after Exposure to Periarterial Blood

Neurosurgery ◽  
1993 ◽  
Vol 33 (4) ◽  
pp. 716-722 ◽  
Author(s):  
Hidetoshi Kasuya ◽  
Bryce Weir ◽  
Youjun Shen ◽  
Gregory Hariton ◽  
Bozena Vollrath ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Arterial Wall ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Beta Gene

Polyamines are necessary for normal expression of the transforming growth factor-beta gene during cell migration

1997 ◽  
Vol 272 (4) ◽  
pp. G713-G720 ◽  
Author(s):  
J. Y. Wang ◽  
M. J. Viar ◽  
J. Li ◽  
H. J. Shi ◽  
S. A. McCormack ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Migration ◽  
Growth Factor ◽  
Epithelial Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Tgf Beta ◽  
Epithelial Cell Migration ◽  
Growth Factor Beta ◽  
Beta Gene

The current study tests the hypothesis that intracellular polyamines are involved in the regulation of gene expression of transforming growth factor-beta (TGF-beta) during epithelial cell migration after wounding. Administration of alpha-difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase (the first rate-limiting enzyme for polyamine synthesis), depleted cellular polyamines putrescine, spermidine, and spermine in IEC-6 cells. DFMO also significantly reduced basal levels of TGF-beta mRNA in unwounded cells. Gene expression of TGF-beta was dramatically stimulated after wounding of a monolayer of cells not treated with DFMO. TGF-beta mRNA levels significantly increased from 4 to 12 h after wounding, peaking at 6 h at a level eight times the prewounding control. Increased levels of TGF-beta mRNA in IEC-6 cells after wounding were paralleled by an increase in TGF-beta content. Depletion of intracellular polyamines in DFMO-treated cells significantly inhibited increased expression of the TGF-beta gene in response to wounding. Cell migration also significantly decreased in DFMO-treated cells. In the presence of DFMO, exogenous TGF-beta restored cell migration to normal. These results indicate that 1) polyamine depletion induced by DFMO is associated with decreases in the expression of the TGF-beta gene and cell migration in IEC-6 cells and 2) exogenous TGF-beta reverses the inhibitory effect of polyamine depletion on cell migration. These findings suggest that polyamines are required for epithelial cell migration in association with their ability to regulate TGF-beta gene expression.

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