The spectrum of cancer in adolescents and young adults (AYAs): An observational study in a single institution from 2015-2019.

e13629 Background: Cancer in adolescents and young adults (AYAOs) refers to patients diagnosed with a malignancy between 16 and 39 years old. This is thought to be 5% in the Western population. The exact incidence and distribution in Asia is uncertain although the WHO estimated 650 000 AYAs to be newly diagnosed in this part of the world in 2018. There is limited data on the incidence and epidemiology on AYAs in Asia, but it is known from the western literature that the distribution of cancer types, clinico-pathological features and outcomes in this population is very different. We therefore, sought to evaluate the pattern of cancer types among the different age groups of the AYA population seen in a high-volume single Asian tertiary cancer centre. Methods: We undertook a retrospective observational study of all patients diagnosed with cancer between 16 and 39 years old who presented to the National Cancer Centre Singapore (NCCS) from 1 January 2015 to 31 December 2019. Results: A total of 2583 cases was observed during the 5-year period. The male: female ratio was 1:1.75. The majority of the patients were between of 35-39 years (y) ( n= 1128, 44.0%). The most common cancer across the different age groups in females were sarcoma (16-19 y), hematologic malignancies (20-24 y) and breast cancer (25-29 y, 30-34 y and 35-39 y). The most common cancer across the different age groups in males were hematologic malignancies (16-19 y), germ cell tumours (20-24 y), germ cell tumours, hematologic malignancies and sarcoma (25-29 y), hematologic malignancies (30-34 y) and colorectal cancers (35-39 y). The majority of the patients presented were localized disease (38.3%), while 19.4% presented with lymphatic involvement. Amongst 507 (19.6%) patients presenting with metastatic disease, 126 patients have deceased. Conclusions: This population has unique characteristics compared to their geriatric and pediatric counterparts. With an increased incidence and expected longer survivals, more efforts are needed to better understand the clinicopathological features of the AYA population. This will enable us to better survival rates and long-term treatment outcomes.

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Melanoma in Adolescents and Young Adults: Evaluation of the Characteristics, Treatment Strategies, and Prognostic Factors in a Monocentric Retrospective Study

Frontiers in Oncology ◽

10.3389/fonc.2021.725523 ◽

2021 ◽

Vol 11 ◽

Author(s):

Paolo Del Fiore ◽

Irene Russo ◽

Beatrice Ferrazzi ◽

Alessandro Dal Monico ◽

Francesco Cavallin ◽

...

Keyword(s):

Young Adults ◽

Tnm Classification ◽

Age Groups ◽

Treatment Strategies ◽

Disease Free Survival ◽

Adolescents And Young Adults ◽

Biological Behavior ◽

Veneto Region ◽

Common Cancer ◽

Caucasian Patients

The “Veneto Cancer Registry” records melanoma as the most common cancer diagnosed in males and the third common cancer in females under 50 years of age in the Veneto Region (Italy). While melanoma is rare in children, it has greater incidence in adolescents and young adults (AYA), but literature offers only few studies specifically focused on AYA melanoma. The aim of this study was to describe the characteristics, surgical treatment, and prognosis of a cohort of AYA melanoma in order to contribute to the investigation of this malignancy and provide better patient care. This retrospective cohort study included 2,752 Caucasian patients (702 AYA and 2,050 non-AYA patients) from the Veneto Region who were over 15 years of age at diagnosis, and who received diagnosis and/or treatment from our institutions between 1998 and 2014. Patients were divided in adolescents and youth (15-25 years), young adults (26-39 years) and adults (more than 39 years) for the analysis. We found statistically significant differences in gender, primary site, Breslow thickness, ulceration, pathologic TNM classification (pTNM) stage and tumor subtype among the age groups. Disease-specific survival and disease-free survival were also different among the age groups. Our findings suggest that the biological behavior of melanoma in young people is different to that in adults, but not such as to represent a distinct pathological entity. Additional and larger prospective studies should be performed to better evaluate potential biological and cancer-specific differences between AYAs and the adult melanoma population.

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Germ Cell Tumors in Adolescents and Young Adults

Journal of Oncology Practice ◽

10.1200/jop.19.00190 ◽

2019 ◽

Vol 15 (8) ◽

pp. 433-441 ◽

Cited By ~ 4

Author(s):

Adriana Fonseca ◽

A. Lindsay Frazier ◽

Furqan Shaikh

Keyword(s):

Young Adults ◽

Germ Cell ◽

Age Groups ◽

Germ Cell Tumors ◽

Adolescents And Young Adults ◽

Childhood Cancers ◽

Therapeutic Approaches ◽

Cancer Specialists ◽

Research Initiatives ◽

Common Malignancy

Germ cell tumors (GCTs) are rare in childhood, representing only 3.5% of childhood cancers, but a common malignancy in adolescents and young adults (AYAs), accounting for 13.9% of neoplasms in adolescents between age 15 and 19 years. The overall outcomes of patients treated for GCTs are excellent. However, as seen in other cancers, outcomes for AYA patients are significantly worse. Understanding the reasons for this observation has led to different approaches to diagnosis, staging, and treatment. The Malignant Germ Cell International Consortium was created to bring together pediatric, gynecologic, and testicular cancer specialists to promote research initiatives and provide evidence-based approaches in the management of GCTs across different age groups. Collaboration between multiple subspecialties is essential to further understand the disease continuum, the underlying biologic characteristics, and the development of appropriate therapeutic approaches. This review focuses on the unique characteristics of patients with extracranial GCTs in the AYA group.

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Adolescents and young adults: A study of distribution of cancer at ages 15–39 years in a tertiary care hospital from North India: Epidemiological considerations

South Asian Journal of Cancer ◽

10.4103/sajc.sajc_263_16 ◽

2017 ◽

Vol 06 (04) ◽

pp. 180-182 ◽

Cited By ~ 1

Author(s):

Neha Kakkar ◽

Ajay Gupta ◽

Neeraj Kumar Sharma ◽

Prachi Agarwal ◽

Jaspreet Kaur

Keyword(s):

Young Adults ◽

Care Center ◽

Tertiary Care ◽

Age Groups ◽

Distribution Patterns ◽

Adolescents And Young Adults ◽

North India ◽

Care Hospital ◽

Common Cancer ◽

Cancer Pattern

Abstract Purpose: This study aimed to analyze cancer pattern among adolescents and young adults (AYA) in a tertiary care center in North India. Materials and Methods: A retrospective study from January 2011 to December 2014 was undertaken on AYA cancer patients (aged 15–39 years). Results: Totally 1077 cases of AYA cancers were identified for analyzing the frequency and pattern of cancer distribution. The most common cancer was head and neck (32%) followed by breast (14.2%). The distribution pattern was observed to be varying in different age groups with lymphoma, leukemia, bone tumors, and sarcomas in adolescents while carcinomas being more frequent in young adults. Conclusion: Cancer distribution patterns are distinct among AYA in terms of epidemiology and biology.

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RARE-06. CANADIAN PATTERNS OF PRACTICE FOR INTRACRANIAL GERM CELL TUMOURS IN ADOLESCENTS AND YOUNG ADULTS

Neuro-Oncology ◽

10.1093/neuonc/nox168.859 ◽

2017 ◽

Vol 19 (suppl_6) ◽

pp. vi212-vi213

Author(s):

Andrea Lo ◽

Normand Laperriere ◽

David Hodgson ◽

Eric Bouffet ◽

James Nicholson ◽

...

Keyword(s):

Young Adults ◽

Germ Cell ◽

Adolescents And Young Adults ◽

Germ Cell Tumours ◽

Patterns Of Practice

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Patient-reported psychosocial distress in adolescents and young adults with germ cell tumours

Supportive Care in Cancer ◽

10.1007/s00520-020-05723-3 ◽

2020 ◽

Author(s):

M. Soleimani ◽

C. Kollmannsberger ◽

A. Bates ◽

B. Leung ◽

Cheryl Ho

Keyword(s):

Young Adults ◽

Germ Cell ◽

Psychosocial Distress ◽

Adolescents And Young Adults ◽

Germ Cell Tumours ◽

Patient Reported

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Kids, Adolescents, and Young Adults Cancer Study—A Methodologic Approach in Cancer Epidemiology Research

Journal of Cancer Epidemiology ◽

10.1155/2009/354257 ◽

2009 ◽

Vol 2009 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Nancy J. Link ◽

Eva Maurer ◽

Joan Largent ◽

Erin Kent ◽

Rebecca A. Morris ◽

...

Keyword(s):

Young Adults ◽

Age Groups ◽

Participation Rate ◽

Population Based ◽

Adolescents And Young Adults ◽

Tumor Type ◽

Methodology Development ◽

Cancer Types ◽

Young Adult Cancer ◽

Made In

Advances have been made in treatment and outcomes for pediatric cancer. However adolescents and young adults (AYAs) with cancer have not experienced similar relative improvements. We undertook a study to develop the methodology necessary for epidemiologic cancer research in these age groups. Our goal was to create the Kids, Adolescents, and Young Adults Cancer (KAYAC) project to create a resource to address research questions relevant to this population. We used a combination of clinic and population-based ascertainment to enroll 111 cases aged 0–39 for this methodology development study. The largest groups of cancer types enrolled include: breast cancer, leukemia, lymphoma, and melanoma. The overall participation rate is 69.8% and varies by age and tumor type. The study included patients, mothers, and fathers. The methods used to establish this resource are described, and the values of the resource in studies of childhood and young adult cancer are outlined.

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The reliability and validity of a screening scale for online gaming disorder among Chinese adolescents and young adults

BMC Psychiatry ◽

10.1186/s12888-021-03678-1 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Xuechan Lyu ◽

Tianzhen Chen ◽

Zhe Wang ◽

Jing Lu ◽

Chenyi Ma ◽

...

Keyword(s):

Young Adults ◽

Age Groups ◽

Reliability And Validity ◽

Online Gaming ◽

Chinese Adolescents ◽

Model Fit ◽

Adolescents And Young Adults ◽

Gaming Disorder ◽

Good Reliability ◽

Screening Scale

Abstract Background In recent years, there have been frequent reports of gaming disorder in China, with more focus on young people. We developed and psychometrically tested a Gaming Disorder screening scale (i.e., Gaming Disorder Screening Scale - GDSS) for Chinese adolescents and young adults, based on the existing scales and diagnostic criteria, but also considering the development status of China. Methods For testing content and criterion validity, 1747 participants competed the GDSS and the Internet Addiction Test (IAT). After 15 days, 400 participants were retested with the scales for to assess test-retest reliability. Besides, 200 game players were interviewed for a diagnosis of gaming disorder. Results The Cronbach’s alpha coefficient on the GDSS was 0.93. The test-retest coefficient of 0.79. Principal components analysis identified three factors accounting for 62.4% of the variance; behavior, functioning, cognition and emotion. Confirmatory factor analysis showed a good model fit to the data (χ2 /df = 5.581; RMSEA =0.074; TLI = 0.916, CFI = 0.928). The overall model fit was significantly good in the measurement invariance tested across genders and different age groups. Based on the clinical interview, the screening cut-off point was determined to be ≥47 (sensitivity 41.4%, specificity 82.3%). Conclusions The GDSS demonstrated good reliability and validity aspects for screening online gaming disorder among Chinese adolescents and young adults.

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