scholarly journals Breaking down barriers: improving outcomes for teenagers and young adults with germ cell tumours

2011 ◽  
Vol 3 (4) ◽  
pp. 201 ◽  
Author(s):  
Matthew J. Murray ◽  
Lorna A. Fern ◽  
Daniel P. Stark ◽  
Tim O. Eden ◽  
James C. Nicholson
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Patient Group ◽  
Age Group ◽  
Germ Cell Tumours ◽  
Teenagers And Young Adults ◽  
Over Time ◽  
Rate Of Improvement

Teenagers and young adults (TYA) with cancer have complex and evolving needs which are unique to this patient group. The TYA age-group have outcomes that are not improving over time, lagging behind both adult and children’s cancers in their rate of improvement in recent years...

scholarly journals Breaking down barriers: improving outcomes for teenagers and young adults with germ cell tumours

10.4081/95 ◽  
2011 ◽  
Vol 3 (4) ◽  
Author(s):  
Matthew J. Murray ◽  
Lorna A. Fern ◽  
Daniel P. Stark ◽  
Tim O. Eden ◽  
James C. Nicholson
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Germ Cell Tumours ◽  
Teenagers And Young Adults

scholarly journals Breaking down barriers: improving outcomes for teenagers and young adults with germ cell tumours

2009 ◽  
Vol 3 (4) ◽  
pp. 201-206 ◽  
Author(s):  
Matthew J. Murray ◽  
Lorna A. Fern ◽  
Daniel P. Stark ◽  
Tim O. Eden ◽  
James C. Nicholson
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Germ Cell Tumours ◽  
Teenagers And Young Adults

scholarly journals GERM-08. EARLIER RECOGNITION OF SYMPTOMS AND DIAGNOSIS MAY REDUCE TREATMENT AND LATE EFFECT BURDEN IN CHILDREN, TEENAGERS AND YOUNG ADULTS WITH INTRACRANIAL GERM CELL TUMOURS

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i84-i85
Author(s):  
James Hayden ◽  
Ute Bartels ◽  
Anthony Penn ◽  
Matthew Murray ◽  
Gabriele Calaminus ◽  
...  
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Late Effect ◽  
Germ Cell Tumours ◽  
Teenagers And Young Adults

scholarly journals Longitudinal cohort study of the impact of specialist cancer services for teenagers and young adults on quality of life: outcomes from the BRIGHTLIGHT study

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e038471
Author(s):  
Rachel M Taylor ◽  
Lorna A Fern ◽  
Julie Barber ◽  
Javier Alvarez-Galvez ◽  
Richard Feltbower ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Cohort Study ◽  
Young People ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Cancer Services ◽  
Teenagers And Young Adults ◽  
Over Time

ObjectivesIn England, healthcare policy advocates specialised age-appropriate services for teenagers and young adults (TYA), those aged 13 to 24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced TYA age-specific care, although many still receive care in adult or children’s cancer services. We present the first prospective structured analysis of quality of life (QOL) associated with the amount of care received in a TYA-PTCDesignLongitudinal cohort study.SettingHospitals delivering inpatient cancer care in England.Participants1114 young people aged 13 to 24 years newly diagnosed with cancer.InterventionExposure to the TYA-PTC defined as patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care.Primary outcomeQuality of life measured at five time points: 6, 12, 18, 24 and 36 months after diagnosis.ResultsGroup mean total QOL improved over time for all patients, but for those receiving NO-TYA-PTC was an average of 5.63 points higher (95% CI 2.77 to 8.49) than in young people receiving SOME-TYA-PTC care, and 4·17 points higher (95% CI 1.07 to 7.28) compared with ALL-TYA-PTC care. Differences were greatest 6 months after diagnosis, reduced over time and did not meet the 8-point level that is proposed to be clinically significant. Young people receiving NO-TYA-PTC care were more likely to have been offered a choice of place of care, be older, from more deprived areas, in work and have less severe disease. However, analyses adjusting for confounding factors did not explain the differences between TYA groups.ConclusionsReceipt of some or all care in a TYA-PTC was associated with lower QOL shortly after cancer diagnosis. The NO-TYA-PTC group had higher QOL 3 years after diagnosis, however those receiving all or some care in a TYA-PTC experienced more rapid QOL improvements. Receipt of some care in a TYA-PTC requires further study.

scholarly journals RARE-06. CANADIAN PATTERNS OF PRACTICE FOR INTRACRANIAL GERM CELL TUMOURS IN ADOLESCENTS AND YOUNG ADULTS

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi212-vi213
Author(s):  
Andrea Lo ◽  
Normand Laperriere ◽  
David Hodgson ◽  
Eric Bouffet ◽  
James Nicholson ◽  
...  
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Adolescents And Young Adults ◽  
Germ Cell Tumours ◽  
Patterns Of Practice

Reproductive outcomes of fertility sparing surgeries in germ cell tumours

2017 ◽  
Vol 6 (2) ◽  
pp. 5266
Author(s):  
Ujwala Prakash Wakpaijan
Keyword(s):  
Overall Survival ◽  
General Population ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Young Patients ◽  
Age Group ◽  
Germ Cell Tumours ◽  
Reproductive Outcome ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

The main aim of the study is to observe the reproductive outcome in patient of germ cell tumour after fertility preserving surgery. In which retrospective records of patients diagnosed with malignant GCT in young patients treated with fertility sparing surgery and chemotherapy for ten years from 2000 to 2009. From the careful observations concluded the overall survival with the patients treated with fertility sparing surgery is excellent and the reproductive outcome is more or less equivalent to the general population of same age group.

scholarly journals Changes over time in young adults' harmful alcohol consumption: A cross-temporal meta-analysis using the AUDIT

2019 ◽  
Author(s):  
Rachel Visontay ◽  
Louise Mewton ◽  
Matthew Sunderland ◽  
Katrina Prior ◽  
Tim Slade
Keyword(s):  
Young Adults ◽  
Alcohol Consumption ◽  
Meta Analysis ◽  
Later Life ◽  
Future Research ◽  
Age Group ◽  
Adult Participation ◽  
Harmful Alcohol ◽  
Changes Over Time ◽  
Over Time

Background: Recent studies suggest that young adult participation in, and volume of, alcohol consumption has decreased. However, the evidence on trends in harmful alcohol consumption in this age group is limited. The current paper aims to examine changes over time in harmful alcohol consumption using a robust, widely employed measure.Methods: The literature was systematically searched for articles reporting on Alcohol Use Disorders Identification Test (AUDIT) scores in young adults aged 18-24 years. The key data extracted were year of measurement and mean AUDIT score (proportion above clinical cut-off was not relevant for these analyses). Cross-temporal meta-analysis was applied to the extracted data.Results: A decrease was found in young adults’ AUDIT scores measured between 1989 and 2015 (b=-0.13, β=-0.38, p=0.015, 95% CI=-0.24, -0.03), representing a 0.63 standard deviation change over this period. Variance did not change over this time, suggesting scores decreased equally over the distribution.Conclusions: Results indicate that harmful alcohol consumption in young adults may have declined between 1989 and 2015. Despite the continued problems posed by dependence and short and long-term harms, these promising findings offer hope that the considerable alcohol-related disease burden in this age group may be reduced.Ongoing data collection is required to evaluate whether these declines in young adulthood persist into later life, and future research should explore the reasons for declining harmful alcohol consumption in young adults.

Outcomes of adolescent males with extracranial malignant germ cell tumors compared with children and young adults: A report from the Malignant Germ Cell Tumors International Consortium (MaGIC) group.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 10022-10022
Author(s):  
Furqan Shaikh ◽  
Daniel P. Stark ◽  
Ha Dang ◽  
Caihong Xia ◽  
Mark D. Krailo ◽  
...  
Keyword(s):  
Young Adults ◽  
Germ Cell ◽  
Risk Group ◽  
Multivariable Analysis ◽  
Germ Cell Tumors ◽  
Age Group ◽  
Platinum Based Chemotherapy ◽  
Adolescent Patients ◽  
The Difference ◽  
Malignant Germ Cell Tumors

10022 Background: Adolescents with extracranial malignant germ cell tumors (GCTs) are often treated on the same regimens developed for children, but more closely resemble the clinical characteristics of young adult patients. We sought to determine whether event-free survival (EFS) for adolescents with GCTs was more like that of children or young adults. Methods: We assembled an individual patient database of ten GCT trials: seven conducted by pediatric cooperative groups and three by an adult group. We selected male patients aged 0-30 years old treated with platinum-based chemotherapy for non-seminomatous malignant GCTs of the testis, retroperitoneum, or mediastinum. We categorized age-group as children (0 to < 11 years), adolescents (11 to < 18 years), or young adults (18 to < 30 years old). We compared EFS among age groups, and adjusted for calculated IGCCCG risk-group using Cox proportional hazards analysis. Results: 593 patients met inclusion criteria, of whom 90 were children, 109 were adolescents, and 394 were young adults. The 5-year EFS for adolescents (72%; CI = 62-79%) was significantly lower than for children (90%; CI = 81-95%, p = 0.003) and for young adults (88%; CI = 84-91%, p < 0.001). Risk-group was significantly associated with EFS in the adolescent age-group (p = 0.002). In a Cox multivariable analysis, the difference between adolescents and children remained statistically significant (HR = 0.30, p = 0.001), but the difference between adolescents and young adults did not (HR 0.66, p = 0.114). Conclusions: EFS for adolescent patients with extracranial malignant GCTs was similar to young adults but significantly worse than children. This finding may have important implications for how adolescent patients are treated.

The spectrum of cancer in adolescents and young adults (AYAs): An observational study in a single institution from 2015-2019.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13629-e13629
Author(s):  
Wei Lin Goh ◽  
Jiancheng Hong ◽  
Evelyn Wong ◽  
Victoria Wong ◽  
Daniel Quah ◽  
...  
Keyword(s):  
Young Adults ◽  
Observational Study ◽  
Germ Cell ◽  
Age Groups ◽  
Hematologic Malignancies ◽  
Adolescents And Young Adults ◽  
Germ Cell Tumours ◽  
Cancer Centre ◽  
Common Cancer ◽  
Cancer Types

e13629 Background: Cancer in adolescents and young adults (AYAOs) refers to patients diagnosed with a malignancy between 16 and 39 years old. This is thought to be 5% in the Western population. The exact incidence and distribution in Asia is uncertain although the WHO estimated 650 000 AYAs to be newly diagnosed in this part of the world in 2018. There is limited data on the incidence and epidemiology on AYAs in Asia, but it is known from the western literature that the distribution of cancer types, clinico-pathological features and outcomes in this population is very different. We therefore, sought to evaluate the pattern of cancer types among the different age groups of the AYA population seen in a high-volume single Asian tertiary cancer centre. Methods: We undertook a retrospective observational study of all patients diagnosed with cancer between 16 and 39 years old who presented to the National Cancer Centre Singapore (NCCS) from 1 January 2015 to 31 December 2019. Results: A total of 2583 cases was observed during the 5-year period. The male: female ratio was 1:1.75. The majority of the patients were between of 35-39 years (y) ( n= 1128, 44.0%). The most common cancer across the different age groups in females were sarcoma (16-19 y), hematologic malignancies (20-24 y) and breast cancer (25-29 y, 30-34 y and 35-39 y). The most common cancer across the different age groups in males were hematologic malignancies (16-19 y), germ cell tumours (20-24 y), germ cell tumours, hematologic malignancies and sarcoma (25-29 y), hematologic malignancies (30-34 y) and colorectal cancers (35-39 y). The majority of the patients presented were localized disease (38.3%), while 19.4% presented with lymphatic involvement. Amongst 507 (19.6%) patients presenting with metastatic disease, 126 patients have deceased. Conclusions: This population has unique characteristics compared to their geriatric and pediatric counterparts. With an increased incidence and expected longer survivals, more efforts are needed to better understand the clinicopathological features of the AYA population. This will enable us to better survival rates and long-term treatment outcomes.

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