scholarly journals Vision loss in glioblastoma: Disease mimicking presumed therapeutic toxicity

2018 ◽  
Vol 5 (4) ◽  
pp. 223-226
Author(s):  
HuyTram N Nguyen ◽  
Kevin B H Vo ◽  
Steven Howard ◽  
M Shahriar Salamat ◽  
Howard Rowely ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Brain Cancer ◽  
Vision Loss ◽  
Recurrent Glioblastoma ◽  
Mri Findings ◽  
First Case ◽  
Tumor Involvement ◽  
Radiation Induced ◽  
Rule Out

Abstract Glioblastoma is the most common and lethal form of primary brain cancer. In the recurrent setting, bevacizumab is a common choice for salvage therapy. Loss of vision in patients initially treated with radiation at the time of diagnosis and later treated with bevacizumab at time of recurrence has been reported, and presumed to be a treatment-related optic neuropathy. Strikingly, only 1 case report described a postmortem biopsy to rule out tumor involvement of the optic tracts. We report the first case of recurrent glioblastoma infiltrating the prechiasmatic and chiasmatic optic nerve, which at the time of vision loss was presumed to be secondary to bevacizumab. It is noteworthy that the MRI findings in the previously reported bevacizumab/radiation-induced optic neuropathy cases (without pathology follow-up) are comparable to our patient.

Early bilateral radiation-induced optic neuropathy with follow-up MRI

1995 ◽  
Vol 37 (2) ◽  
pp. 131-133 ◽  
Author(s):  
R. L. McClellan ◽  
T. El Gammal ◽  
L. B. Kline
Keyword(s):  
Optic Neuropathy ◽  
Radiation Induced

scholarly journals Prenatal Diagnosis of Intracranial Tumors and the Difficulties in Prognostication: A Report of Three Cases

2015 ◽  
Vol 6 (2) ◽  
pp. 88-91
Author(s):  
Lavanya Rai ◽  
Akhila Vasudeva ◽  
Sapna V Amin ◽  
Rajagopal Kadavigere ◽  
Katta M Girisha
Keyword(s):  
Prenatal Diagnosis ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Good Prognosis ◽  
Neurological Involvement ◽  
Intracranial Tumors ◽  
Prenatal Mri ◽  
First Case ◽  
Rule Out

ABSTRACT Prenatal diagnosis of intracranial tumors generally implies a poor prognosis. We present three such cases, where prognostication was difficult. We attempted to correlate our prenatal counseling with postnatal follow-up/postabortal diagnosis. In the first case, tumor was diagnosed at 37 weeks. Ultrasound and fetal/neonatal MRI suggested a malignant intraventricular tumor. Anticipating guarded prognosis, parents refused neurosurgical intervention. At 1 year, child has normal neurodevelopment. Further magnetic resonance imagings (MRIs) show tumor shrinkage, pointing to a benign tumor. In case two, a choroid plexus tumor was diagnosed at midtrimester anomaly scan. Since it was difficult to rule out a malignant tumor, pregnancy was terminated. However, MRI, autopsy, and histopathology confirmed a choroid plexus papilloma, which is known to have good prognosis. In case three, prenatal MRI showed features of neurological involvement in tuberous sclerosis. However child has no neurological manifestations at 1 year of age. Hence, prognostication of prenatally diagnosed brain tumors remains a challenge. How to cite this article Vasudeva A, Amin SV, Kadavigere R, Girisha KM, Rai L. Prenatal Diagnosis of Intracranial Tumors and the Difficulties in Prognostication: A Report of Three Cases. Int J Infertil Fetal Med 2015;6(2):88-91.

Anterior and posterior ischemic optic neuropathy following liposuction surgery in a previously healthy young woman

2020 ◽  
pp. 112067212096206
Author(s):  
Kaveh Abri Aghdam ◽  
Ali Sadeghi ◽  
Mostafa Soltan Sanjari ◽  
Ali Aghajani ◽  
Saba Gholamalizadeh
Keyword(s):  
Optic Neuropathy ◽  
Vision Loss ◽  
Ischemic Optic Neuropathy ◽  
Laboratory Studies ◽  
Level Of Evidence ◽  
Healthy Young Woman ◽  
Posterior Ischemic Optic Neuropathy ◽  
The Right ◽  
Liposuction Surgery

A previously healthy 28-year-old female developed bilateral painless vision loss, more prominent in the right eye than in the left, following abdominoplasty and liposuction surgery. Laboratory studies showed severe peri- and post-operative anemia. Over a 5-month follow-up, visual function remained decreased but stable in the right eye and improved in the left eye. This is the second reported case of anterior ischemic optic neuropathy in one eye and posterior ischemic optic neuropathy in the other eye after liposuction. Level of evidence: Level VI, case report study.

The visual evoked potential can save sight in patients with radiation-induced optic neuropathy

2021 ◽  
pp. 112067212110491
Author(s):  
Ali Nouraeinejad
Keyword(s):  
Radiation Therapy ◽  
Diagnostic Test ◽  
Optic Neuropathy ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Vision Loss ◽  
Late Complication ◽  
Clinical Signs ◽  
Radiation Induced ◽  
Visual Evoked

Radiation-induced optic neuropathy (RION) is a late complication of radiation therapy for brain and skull base tumors. RION leads to the devastating total vision loss in one or both eyes. Therefore, the early detection of RION is vital. Since visual symptoms and clinical signs of RION are not present at early stages of the radiation injury, it is essential to apply a diagnostic test to detect RION as early as possible in order to start therapeutic interventions. The author proposes to apply visual evoked potential (VEP) as a diagnostic test in the interval time after radiation therapy.

Early bilateral radiation-induced optic neuropathy with follow-up MRI

1995 ◽  
Vol 37 (2) ◽  
pp. 131-133 ◽  
Author(s):  
R. L. McClellan ◽  
T. El Gammal ◽  
L. B. Kline
Keyword(s):  
Optic Neuropathy ◽  
Radiation Induced

Percutaneous treatment of an intraorbital arteriovenous malformation using a transvenous approach: A case report

2021 ◽  
pp. 159101992199139
Author(s):  
François Dantas ◽  
Tiago Silva e Carvalho ◽  
Róberti Uili Rodrigues Firmino ◽  
Alexandre Amaral Yung ◽  
Renata Caroline Ferreira Gomes ◽  
...  
Keyword(s):  
Vision Loss ◽  
Treatment Options ◽  
Percutaneous Treatment ◽  
Venous Aneurysm ◽  
Superior Ophthalmic Vein ◽  
Direct Puncture ◽  
First Case ◽  
Transvenous Approach ◽  
Actual Prevalence

Intraorbital arteriovenous malformations (AVMs) are extremely rare, and their actual prevalence is unknown. There is no consensus regarding the best treatment options, and the treatment is usually challenging, involving endovascular and other surgical procedures. Herein, we report the case of a patient diagnosed with an intraorbital AVM, presenting with thrombosis and hemorrhage, with rapidly progressive proptosis, chemosis, ophthalmoparesis, and vision loss. Treatment was performed with a transorbital puncture targeting a venous aneurysm of the superior ophthalmic vein, and closure of the AVM was possible with the use of coils and Onyx. We obtained anatomical occlusion of the lesion, and the patient showed progressive improvement of chemosis, vision acuity, and ophthalmoparesis. At six-month’ follow-up, only mild proptosis was noted, and a control digital subtraction angiography confirmed complete closure of the AVM, with no residual lesion. To date, this is the first case of an intraorbital AVM treated with transorbital direct puncture.

scholarly journals Catastrophic vision loss from radiation-induced optic neuropathy

2020 ◽  
Vol 13 (2) ◽  
pp. e233706
Author(s):  
Sultan Aldrees ◽  
Jonathan A Micieli
Keyword(s):  
Optic Neuropathy ◽  
Vision Loss ◽  
High Dose ◽  
Ophthalmological Examination ◽  
Light Perception ◽  
Motion Vision ◽  
Hand Motion ◽  
Radiation Induced ◽  
The Right ◽  
The Brain

A 68-year-old woman presented with profound vision loss of 2-month duration in the right eye and 1-week duration in her left eye. This occurred in the context of craniopharyngioma that was twice resected and irradiated (54 Gy in 30 fractions) 9 months before her presentation. Ophthalmological examination revealed hand motion vision in the right eye and light perception vision in the left eye with poorly reactive pupils and bilateral optic disc pallor. A non-contrast MRI of the brain and sella showed significant reduction of the sellar mass. A repeat MRI of the brain and orbits with gadolinium showed pre-chiasmatic enhancement of both optic nerves. The diagnosis of radiation-induced optic neuropathy was made. Despite treatment with high-dose intravenous corticosteroids, 19 sessions of hyperbaric oxygen therapy, and 3 doses of intravenous bevacizumab, her vision worsened to no light perception in both eyes.

A Rare Case of Steroid-Resistant Neurosarcoidosis of the Cavernous Sinus With Optic Neuropathy: A Case Report

2021 ◽  
pp. 194187442199364
Author(s):  
Shiva Barforoshi ◽  
Nikhil A. Patel ◽  
Alvin P. Singh ◽  
Terrence Li ◽  
Benjamin Mba
Keyword(s):  
Nervous System ◽  
Combination Therapy ◽  
Cavernous Sinus ◽  
Optic Neuropathy ◽  
Vision Loss ◽  
Clinical Manifestations ◽  
Mediastinal Lymphadenopathy ◽  
Mri Findings ◽  
History Of ◽  
The Right

Sarcoidosis is an inflammatory disease that presents with nervous system involvement in 5-10% of cases, commonly known as neurosarcoidosis.1 While there are no randomized controlled trials for the treatment of neurosarcoidosis, expert opinion supports initial treatment with corticosteroids and the use of steroid-sparing or anti-TNF agents in refractory or severe cases. We report a case of a 48-year-old African American male with a past medical history of biopsy-proven hepatic and renal sarcoidosis and progressive headache, dizziness, and blurry vision for 5 months, presenting with an acute exacerbation of right-sided vision loss over one day. MRI of the brain revealed a dural-based mass extending into the right cavernous sinus and compressing the right optic nerve. Given the pathological confirmation of systemic granulomatous disease consistent with sarcoidosis, clinical manifestations, bilateral hilar and mediastinal lymphadenopathy, MRI findings typical of central nervous system inflammation, and exclusion of other possible etiologies, the patient was diagnosed with probable neurosarcoidosis. Corticosteroids initially resolved his symptoms; however, he suffered an acute relapse. Combination therapy with corticosteroids plus mycophenolate mofetil (MMF) led to the eventual resolution of his symptoms. Only 8 cases of neurosarcoidosis involving the cavernous sinus have been reported. Our patient represents the only reported case of probable neurosarcoidosis of the cavernous sinus with optic neuropathy successfully treated with corticosteroid plus MMF combination therapy. We highlight the need to consider early, aggressive treatment in cases of neurosarcoidosis with optic neuropathy and to develop criteria to guide treatment strategy based on neurolocalization and the degree of neurological disability.

Compressive optic neuropathy caused by renal osteodystrophy

2001 ◽  
Vol 95 (4) ◽  
pp. 704-709 ◽  
Author(s):  
Richard H. Schmidt ◽  
Lisa A. Rietz ◽  
Bhupendra C. K. Patel ◽  
Anne G. Osborne ◽  
David Pratt ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Renal Osteodystrophy ◽  
Vision Loss ◽  
Cranial Neuropathy ◽  
High Dose ◽  
Skull Base Tumors ◽  
Compressive Optic Neuropathy ◽  
Content Type ◽  
Canal Stenosis ◽  
First Case

✓ Compressive optic neuropathy with acute or chronic vision loss has been associated with various skull base tumors, aneurysms, Graves disease, trauma, and, less commonly, fibrous dysplasia and osteopetrosis. The authors present a case of acute visual deterioration in a 25-year-old woman who had massive calvarial hypertrophy with optic canal stenosis secondary to renal osteodystrophy (uremic leontiasis ossea [ULO]: bighead disease). Significant visual field restoration was achieved with high-dose corticosteroids followed by optic nerve decompression. This is the first case report of cranial neuropathy associated with ULO.

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