Opioid use disorder trends from 2002 to 2017 by cigarette smoking status in the United States
Abstract Background There have been significant increases in opioid use and opioid-related overdose deaths in the United States (US). While cigarette smoking remains disproportionately high among individuals with opioid use disorder (OUD), it is unknown whether trends in OUD differ by cigarette use. This study examined differences in OUD by smoking status and trends in OUD by smoking status over time. Methods Data were harnessed from US National Surveys on Drug Use and Health, annual cross-sectional, nationally representative samples of individuals aged 12 and older. Past-year OUD prevalences were estimated each year from 2002-2017 among persons with current daily, current non-daily, former, and never cigarette smoking (n=891,548). Linear time trends of OUD were assessed using logistic regression models. Results In 2017, OUD was significantly more common among persons with daily (2.6%) and non-daily (1.5%) smoking compared to those with former (0.5%) or never (0.2%) smoking. Overall, the prevalence of OUD increased between 2002-2017, although trends differed by smoking status. Adjusting for demographics, the prevalence of OUD increased significantly among individuals with daily (AOR=1.06, 95% CI: 1.04, 1.07), non-daily (AOR=1.03, 95% CI: 1.01, 1.05), and former smoking (AOR=1.05; 95% CI: 1.02, 1.09), but decreased among those who never smoked (AOR=0.98; 95% CI: 0.97, 0.99). Conclusions In the US, the prevalence of OUD was higher among individuals with current cigarette smoking relative to those with former and never smoking. OUD increased among persons with current and former smoking from 2002-2017, in contrast to a decrease in OUD among those who never smoked. Implications Opioid use disorders (OUDs) are increasing in the United States (US) and are associated with difficulty quitting cigarettes. Our data from representative national samples of US individuals showed that although OUD increased among those with both current and former smoking over time, OUD remained significantly higher among persons with current (daily and non-daily) smoking versus persons who formerly smoked cigarettes. In addition, youth with cigarette smoking had particularly high prevalences of OUDs. Cigarette smoking may be important to address alongside OUD to reduce the harmful consequences of OUD and cigarette use especially among younger individuals.