scholarly journals Dose–response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Vol 79 (1) ◽  
pp. 66-75
Author(s):  
Ryoichi Tagawa ◽  
Daiki Watanabe ◽  
Kyoko Ito ◽  
Keisuke Ueda ◽  
Kyosuke Nakayama ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Dose Response ◽  
Protein Intake ◽  
Controlled Trials ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Randomized Controlled

Abstract Context Lean body mass is essential for health, yet consensus regarding the effectiveness of protein interventions in increasing lean body mass is lacking. Objective The aim of this systematic review was to evaluate the dose–response relationship of the effects of protein intake on lean body mass. Data Sources The PubMed and Ichushi-Web databases were searched electronically, and reference lists of the literature included here and in other meta-analyses were searched manually. Study Selection Randomized controlled trials evaluating the effects of protein intake on lean body mass were included. Data Extraction Two authors independently screened the abstracts; 5 reviewed the full texts. Results A total of 5402 study participants from 105 articles were included. In the multivariate spline model, the mean increase in lean body mass associated with an increase in protein intake of 0.1 g/kg of body weight per day was 0.39 kg (95%CI, 0.36–0.41) and 0.12 kg (95%CI, 0.11–0.14) below and above the total protein intake of 1.3 g/kg/d, respectively. Conclusions These findings suggest that slightly increasing current protein intake for several months by 0.1 g/kg/d in a dose-dependent manner over a range of doses from 0.5 to 3.5 g/kg/d may increase or maintain lean body mass. Systematic Review Registration UMIN registration number UMIN000039285.

scholarly journals Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Author(s):  
Ryoichi Tagawa ◽  
Daiki Watanabe ◽  
Kyoko Ito ◽  
Keisuke Ueda ◽  
Kyosuke Nakayama ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Dose Response ◽  
Protein Intake ◽  
Data Extraction ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Randomized Controlled ◽  
Manual Search

AbstractBackgroundLean body mass (LBM) is essential for health; however, consensus regarding the effectiveness of protein interventions in increasing LBM is lacking.ObjectiveEvaluate the dose-response relationship of the effects of protein on LBM.Data SourcesPubMed and Ichushi-Web databases were searched. A manual search of the references of the literature included here and in other meta-analyses was conducted.Study SelectionRandomized controlled trials evaluating the effect of protein intake on LBM were included.Data ExtractionTwo researchers independently screened the abstracts; five reviewed the full-texts.Results5402 subjects from 105 articles were included. In the multivariate-spline model, the mean and corresponding 95% confidence intervals (CIs) for LBM increase for 0.1 g/kg body weight (BW)/day increment was 0.39 [95% CI, 0.36–0.41] kg and 0.12 [0.11–0.14] kg below and above total protein intake 1.3 g/kg BW/day, respectively.ConclusionsOur findings suggest that slightly increasing current protein intake for several months by 0.1 g/kg BW/day may increase or maintain LBM in a dose-response manner from 0.5 to 3.5 g/kg BW/day.

scholarly journals The Protein Recommended Dietary Allowance Is Adequate to Retain Lean Body Mass: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (P08-065-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Joshua Hudson ◽  
Yu Wang ◽  
Robert Bergia ◽  
Wayne Campbell
Keyword(s):  
Systematic Review ◽  
Body Composition ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Nitrogen Balance ◽  
Meta Analysis ◽  
Whole Body ◽  
Controlled Trials ◽  
Randomized Controlled

Abstract Objectives Classic short-term nitrogen balance research estimated that the Recommended Dietary Allowance (RDA) of 0.8 g protein/kg/d would be adequate to maintain whole-body nitrogen balance in 97.5% of the population. However, achieving whole-body nitrogen balance does not necessarily equate with tissue-specific amino acid (nitrogen) needs, for example in skeletal muscle. The objective of this systematic review and meta-analysis was to assess in weight-stable adults the effects of chronically consuming greater than the protein RDA, compared to the RDA, on whole-body composition. Methods Articles published through 2018 were identified with PubMed, Scopus, Cochrane, and CINAHL databases. Five articles with 7 comparisons were identified to be relevant through the databases and through screening previous published reviews. Two researchers independently screened the articles for eligible randomized controlled trials (RCTs) of parallel design that measured changes in body composition after ³6 wk of dietary control. Results There was significant heterogeneity in the effect sizes amongst the comparisons (I2  = 72.8%, χ2  = 22.1, P = 0.001). Consuming greater than the protein RDA did not differentially affect any of the changes in total body mass [0.07 kg (−0.75, 0.88); WMD, (95% CI), Random effects], fat mass [−0.65 kg (−1.33, 0.03)], or lean body mass [0.08 kg (−0.59, 0.75)]. Conclusions These results from controlled feeding RCTs support adequacy of the protein RDA to retain lean body mass and indicate that protein intakes greater than the RDA do not promote morphological changes among weight-stable adults. Funding Sources Purdue University Graduate Lynn Fellowship. No external funding was provided for this review.

scholarly journals Effects of Exercise Interventions on Weight, Body Mass Index, Lean Body Mass and Accumulated Visceral Fat in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 18 (5) ◽  
pp. 2635
Author(s):  
Hyun Suk Lee ◽  
Junga Lee
Keyword(s):  
Body Mass Index ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Visceral Fat ◽  
Exercise Intervention ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Exercise Interventions ◽  
Randomized Controlled

(1) Background: Exercise interventions for overweight and obese individuals help reduce accumulated visceral fat, which is an indicator of cardiometabolic risk, but the effectiveness of these interventions is controversial. The purpose of this meta-analysis was to investigate the effectiveness of exercise interventions in overweight and obese individuals in order to reduce weight, body mass index (BMI), and accumulated visceral fat, and increase lean body mass. (2) Methods: Databases were used to select eligible studies for this meta-analysis. Randomized controlled trials with control and experimental groups were included. The degrees of effectiveness of the exercise interventions were computed to assess the benefits on reducing weight, BMI, and accumulated visceral fat, and increasing lean body mass. (3) Results: Sixteen studies were included in this meta-analysis. Participation in exercise interventions reduced weight (d = −0.58 (95% confidence interval (CI), −0.84–−0.31; p < 0.001; k = 9)), BMI (d = −0.50 (95% CI, −0.78–−0.21; p < 0.001; k = 7)), and accumulated visceral fat (d = −1.08 (95% CI, −1.60–−0.57; p < 0.001; k = 5)), but did not significantly increase lean body mass (d = 0.26 (95% CI, −0.11–0.63; p = 0.17; k = 6)). The average exercise intervention for overweight and obese individuals was of moderate to vigorous intensity, 4 times per week, 50 min per session, and 22 weeks duration. (4) Conclusions: Participating in exercise interventions has favorable effects on weight, BMI, and accumulated visceral fat. Further studies considering different modalities, intensities, durations, and measurements of fatness need to be conducted.

Abstract P209: Dose-Response Relationship Between Dietary Intake of Alpha-linolenic Acid and Risk of Coronary Heart Disease: A Meta-analysis of Prospective Studies

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Jingkai Wei ◽  
Yuzhi Xi ◽  
Ruixue Hou ◽  
Alysse Kowalski ◽  
Hao Sun ◽  
...  
Keyword(s):  
Dose Response ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Controlled Trials ◽  
Response Relationship ◽  
Alpha Linolenic Acid ◽  
Dose Response Relationship ◽  
Randomized Controlled ◽  
Chd Risk ◽  
Reduced Risk

Introduction: Previous studies show that alpha-linolenic acid (ALA) is associated with reduced risk of coronary heart disease (CHD). However, it remains unclear whether and how dietary ALA doses are related to CHD. Hypothesis: We hypothesized that higher dietary ALA intake is associated with a greater reduction in risk of CHD. Methods: We searched PubMed, EMBASE, and Web of Science for prospective studies examining the association between dietary ALA intake and CHD risk. Dietary ALA intake was assigned or measured by self-report. Outcomes were reported as total and fatal CHD and/or myocardial infarction, which were obtained from blinded endpoint assessments or medical records. Two-stage fixed-effects dose-response meta-analyses were conducted to estimate the association between increasing ALA intake (relative to study-specific referents) and CHD. Results: Fifteen published articles were identified and included in the meta-analysis (13 cohort studies and 2 randomized controlled trials). The pooled analysis was based on 310,768 individuals with 12,049 events with a mean length of follow-up of 9.6 years. The analysis showed a J-shaped curve between ALA intake and relative risk of total CHD (Chi-square=21.08, p<0.001). ALA intake from 0.3-1.4g/day showed reduced risk of total CHD, while intake ≥2.5g/day was associated with increased risk of CHD, compared to people without ALA intake (Figure 1A). Approximately 1g/day of ALA intake was associated with the lowest risk of total CHD. ALA intake was linearly associated with fatal CHD - every 1g/day increase in ALA intake was associated with an 11% decrease in fatal CHD risk (95% CI: -0.16, -0.05) (Figure 1B). Conclusion: The J-shaped dose-response relationship based on our pooled analysis suggests that 1g/day of dietary ALA may be optimal for total CHD prevention. Though a higher dietary ALA intake was associated with reduced risk of fatal CHD, the excess total CHD risk at higher ALA intakes warrants further investigation, especially through randomized controlled trials.

Trimodal prehabilitation for colorectal surgery attenuates post-surgical losses in lean body mass: A pooled analysis of randomized controlled trials

2019 ◽  
Vol 38 (3) ◽  
pp. 1053-1060 ◽  
Author(s):  
Chelsia Gillis ◽  
Tanis R. Fenton ◽  
Tolulope T. Sajobi ◽  
Enrico Maria Minnella ◽  
Rashami Awasthi ◽  
...  
Keyword(s):  
Colorectal Surgery ◽  
Randomized Controlled Trials ◽  
Lean Body Mass ◽  
Body Mass ◽  
Pooled Analysis ◽  
Controlled Trials ◽  
Randomized Controlled
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