Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection

Abstract Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic inflammation in early treated PWH.

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Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection

The Journal of Infectious Diseases ◽

10.1093/infdis/jiw173 ◽

2016 ◽

Vol 214 (3) ◽

pp. 408-416 ◽

Cited By ~ 40

Author(s):

Álvaro H. Borges ◽

Jemma L. O'Connor ◽

Andrew N. Phillips ◽

James D. Neaton ◽

Birgit Grund ◽

...

Keyword(s):

Hiv Infection ◽

Interleukin 6 ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

Clinical Events ◽

D Dimer

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Effects of Caloric Restriction and Exercise on Age-Related, Chronic Inflammation Assessed by C-Reactive Protein and Interleukin-6

The Journals of Gerontology Series A ◽

10.1093/gerona/61.3.211 ◽

2006 ◽

Vol 61 (3) ◽

pp. 211-217 ◽

Cited By ~ 57

Author(s):

R. Kalani ◽

S. Judge ◽

C. Carter ◽

M. Pahor ◽

C. Leeuwenburgh

Keyword(s):

Chronic Inflammation ◽

Caloric Restriction ◽

Interleukin 6 ◽

C Reactive Protein ◽

Reactive Protein ◽

Age Related

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Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation

BMC Research Notes ◽

10.1186/s13104-019-4855-2 ◽

2019 ◽

Vol 12 (1) ◽

Cited By ~ 4

Author(s):

Tammy A. Butterick ◽

Janeen H. Trembley ◽

Laura L. Hocum Stone ◽

Clemma J. Muller ◽

Rebecca R. Rudquist ◽

...

Keyword(s):

Chronic Inflammation ◽

Interleukin 6 ◽

Well Being ◽

Gulf War ◽

Blood Levels ◽

C Reactive Protein ◽

Gulf War Illness ◽

Memory Impairments ◽

Reactive Protein ◽

Gastrointestinal Problems

Abstract Objective Gulf War Illness is a chronic multisymptom disorder severely impacting the health and well-being of many Veterans of the 1990–1991 Gulf War. Symptoms that define the disease include pain, fatigue, mood and memory impairments, gastrointestinal problems, lung disorders, and skin rashes. In our previous biomarker study, we discovered Gulf War Illness-associated proinflammatory blood biomarkers. Therefore, we hypothesized that chronic inflammation causes the symptoms that define this disorder. Testing the chronic inflammation hypothesis is the objective of this study. Results The biomarker fingerprint of Gulf War Illness is the end-product of a cascade of proinflammatory cytokine signals. In particular, the observed increase in C-reactive protein predicts a corresponding increase in interleukin 6, the cytokine that stimulates hepatocytes to produce C-reactive protein. Therefore, in this study we measured potential upstream cytokine signals in plasma samples from Gulf War Veterans. As predicted, a positive correlation between interleukin 6 and C-reactive protein was observed.

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