scholarly journals Switching Tenofovir/Emtricitabine/Efavirenz (TDF/FTC/EFV) to TDF/FTC/Rilpivirine vs Continuing TDF/FTC/EFV in HIV-Infected Patients With Virological Suppression: A Randomized Controlled Trial

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Sirichai Wiriyatanakorn ◽  
Somnuek Sungkanuparph
Keyword(s):  
Central Nervous System ◽  
Randomized Controlled Trial ◽  
Nervous System ◽  
Adverse Effects ◽  
Viral Suppression ◽  
Controlled Trial ◽  
Virological Suppression ◽  
Randomized Controlled ◽  
Resource Limited ◽  
Limited Setting

AbstractA randomized controlled noninferiority trial was conducted in HIV-infected patients receiving tenofovir/emtricitabine/efavirenz (TDF/FTC/EFV) with virological suppression in a resource-limited setting. Switching to TDF/FTC/rilpivirine was noninferior to continuing TDF/FTC/EFV in terms of maintaining compete viral suppression at 24 weeks and provided better lipid profiles and fewer central nervous system adverse effects.

scholarly journals Effect of Attentional Focus Instructions on Motor Learning and Performance of Patients with Central Nervous System and Musculoskeletal Disorders: a Systematic Review

2018 ◽  
Vol 3 (3) ◽  
pp. 40 ◽  
Author(s):  
Alessandro Piccoli ◽  
Giacomo Rossettini ◽  
Simone Cecchetto ◽  
Antonello Viceconti ◽  
Diego Ristori ◽  
...  
Keyword(s):  
Systematic Review ◽  
Central Nervous System ◽  
Randomized Controlled Trial ◽  
Nervous System ◽  
Motor Learning ◽  
Controlled Trial ◽  
Attentional Focus ◽  
Focus Of Attention ◽  
Improve Performance ◽  
Randomized Controlled

Exercise is one of the main rehabilitative interventions, commonly used to improve performance and motor learning. During the application of attentional focus strategies, External Focus of Attention (EFA) aiming at the movement effect has been reported to have more efficacy than Internal Focus of Attention (IFA) aiming at movement characteristics in healthy subjects. There are not many studies that compare the EFA and IFA instructions in people with Musculoskeletal (MSK) and Central Nervous System disorders (CNS). The purpose of this systematic review is to determine if IFA or EFA, in patients with CNS or MSK, may improve performance and have some effects on motor learning. Databases used for research: PubMed, CINAHL, Cochrane Library, PEDro, PsycINFO, SCOPUS. Inclusion criteria: Randomized Controlled Trial, quasi-Randomized Controlled Trial, enrolled subjects with CNS or with MSK and compared the efficacy of EFA and IFA. The studies suggest that the EFA is better than IFA in affecting the movement execution in patients with MSK, while conflicted findings emerge in presence of CNS disorders. Studies included in the qualitative analysis showed heterogeneous methodological features in study design and conductance, so results must be interpreted with caution.

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