scholarly journals Contralateral S1 nerve root transfer for motor function recovery in the lower extremity among patients with central nervous system injury: study protocol for a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ying Peng ◽  
Shi-Feng Kan ◽  
Wei-Jie Ren ◽  
Zhuo-Xuan Li ◽  
Gang Yin ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Randomized Controlled Trial ◽  
Nervous System ◽  
Lower Extremity ◽  
Motor Function ◽  
Study Protocol ◽  
Nerve Root ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Function Recovery

scholarly journals Switching Tenofovir/Emtricitabine/Efavirenz (TDF/FTC/EFV) to TDF/FTC/Rilpivirine vs Continuing TDF/FTC/EFV in HIV-Infected Patients With Virological Suppression: A Randomized Controlled Trial

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Sirichai Wiriyatanakorn ◽  
Somnuek Sungkanuparph
Keyword(s):  
Central Nervous System ◽  
Randomized Controlled Trial ◽  
Nervous System ◽  
Adverse Effects ◽  
Viral Suppression ◽  
Controlled Trial ◽  
Virological Suppression ◽  
Randomized Controlled ◽  
Resource Limited ◽  
Limited Setting

AbstractA randomized controlled noninferiority trial was conducted in HIV-infected patients receiving tenofovir/emtricitabine/efavirenz (TDF/FTC/EFV) with virological suppression in a resource-limited setting. Switching to TDF/FTC/rilpivirine was noninferior to continuing TDF/FTC/EFV in terms of maintaining compete viral suppression at 24 weeks and provided better lipid profiles and fewer central nervous system adverse effects.

scholarly journals Early, intensive rehabilitation improves gross motor function after perinatal stroke: results of a randomized controlled trial

2021 ◽  
Author(s):  
Caitlin Hurd ◽  
Donna Livingstone ◽  
Kelly Brunton ◽  
Allison T Smith ◽  
Monica A Gorassini ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lower Extremity ◽  
Motor Function ◽  
Controlled Trial ◽  
Weight Bearing ◽  
Delay Group ◽  
Gross Motor ◽  
Perinatal Stroke ◽  
Gross Motor Function ◽  
Randomized Controlled

Background: Perinatal stroke injures motor regions of the brain, compromising movement for life. Early, intensive, active interventions for the upper extremity are efficacious, but interventions for the lower extremity (LE) remain infrequent and understudied. Objective: To determine the efficacy of ELEVATE – Engaging the Lower Extremity Via Active Therapy Early – on gross motor function, as compared to usual care. Methods: We conducted a single–blind, two–arm, randomized controlled trial (RCT), with the Immediate Group receiving the intervention while the Delay Group served as a three–month waitlist-control. A separate cohort living beyond commuting distance was trained by their parents with guidance from physical therapists. Participants were 8 months to 3 years old, with MRI–confirmed perinatal ischemic stroke and early signs of hemiparesis. The intervention was play–based, focused on weight–bearing, balance and walking for 1 hour/day, 4 days/week for 12 weeks. The primary outcome was the Gross Motor Function Measure–66 (GMFM–66). Secondary outcomes included steps and gait analyses. Final follow–up occurred at age four. Results: Thirty–four children participated (25 RCT, 9 Parent-trained). The improvement in GMFM–66 over 12 weeks was greater for the Immediate than the Delay Group (average change 3.4 units higher) and greater in younger children. Average step counts reached 1370–3750 steps/session in the last week of training for all children. Parent–trained children also improved but with greater variability. Conclusions: Early, activity–intensive LE therapy for young children with perinatal stroke is feasible and improves gross motor function in the short term. Longer term improvement may require additional bouts of intervention.

scholarly journals Effect of Attentional Focus Instructions on Motor Learning and Performance of Patients with Central Nervous System and Musculoskeletal Disorders: a Systematic Review

2018 ◽  
Vol 3 (3) ◽  
pp. 40 ◽  
Author(s):  
Alessandro Piccoli ◽  
Giacomo Rossettini ◽  
Simone Cecchetto ◽  
Antonello Viceconti ◽  
Diego Ristori ◽  
...  
Keyword(s):  
Systematic Review ◽  
Central Nervous System ◽  
Randomized Controlled Trial ◽  
Nervous System ◽  
Motor Learning ◽  
Controlled Trial ◽  
Attentional Focus ◽  
Focus Of Attention ◽  
Improve Performance ◽  
Randomized Controlled

Exercise is one of the main rehabilitative interventions, commonly used to improve performance and motor learning. During the application of attentional focus strategies, External Focus of Attention (EFA) aiming at the movement effect has been reported to have more efficacy than Internal Focus of Attention (IFA) aiming at movement characteristics in healthy subjects. There are not many studies that compare the EFA and IFA instructions in people with Musculoskeletal (MSK) and Central Nervous System disorders (CNS). The purpose of this systematic review is to determine if IFA or EFA, in patients with CNS or MSK, may improve performance and have some effects on motor learning. Databases used for research: PubMed, CINAHL, Cochrane Library, PEDro, PsycINFO, SCOPUS. Inclusion criteria: Randomized Controlled Trial, quasi-Randomized Controlled Trial, enrolled subjects with CNS or with MSK and compared the efficacy of EFA and IFA. The studies suggest that the EFA is better than IFA in affecting the movement execution in patients with MSK, while conflicted findings emerge in presence of CNS disorders. Studies included in the qualitative analysis showed heterogeneous methodological features in study design and conductance, so results must be interpreted with caution.

scholarly journals Assessment of virtual teacher feedback for the recovery of the upper limb after a stroke. Study protocol for a randomized controlled trial.

2016 ◽  
Vol 20 (3) ◽  
pp. 13-20 ◽  
Author(s):  
Pawel Kiper ◽  
Carla Zucconi ◽  
Michela Agostini ◽  
Alfonc Baba ◽  
Francesco Dipalma ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Virtual Reality ◽  
Motor Function ◽  
Visual Feedback ◽  
Study Protocol ◽  
Upper Limb ◽  
Controlled Trial ◽  
Teacher Feedback ◽  
Randomized Controlled ◽  
Stroke Study

Enhanced feedback provided by virtual reality has been shown to promote motor learning both in healthy subjects and patients with motor impairments following lesions of the central nervous system. The aim of this study is to evaluate the effect of displaying a virtual teacher as visual feedback to promote the recovery of upper limb motor function after a stroke. The protocol reports the design of a single blind randomized controlled trial (RCT), blinded to outcome assessment. Two different treatments based on virtual reality will be compared: in the “Teacher” group, the patients receive treatment with continuous displaying of a virtual teacher, while in the “No-Teacher” group, the same exercises will be proposed without visualization of a virtual teacher. The Fugl-Meyer upper extremity scale will be considered as the primary outcome, while the Functional Independence Measure scale, Reaching Performance Scale and Modified Ashworth Scale will be considered as secondary outcomes. Moreover, kinematic parameters such as mean duration (seconds), mean linear velocity (cm/s) and smoothness (i.e. number of sub-movements) will be registered when performing standardised tasks. All tests will be performed before and after treatments. Both treatments will last four weeks with a daily session lasting one hour, five days a week (20 overall sessions). This study is designed to systematically assess the influence of using enhanced visual feedback for the recovery of upper limb motor function after a stroke. These findings will help to determine whether the use of a virtual teacher as enhanced visual feedback is effective for promoting better recovery of upper limb motor function over four weeks of post-stroke treatment. Current Controlled Trials registration number: NCT02234531 (registered on 29 August 2014, ClinicalTrials. gov) Kiper P., Zucconi C., Agostini M., Baba A., Dipalma F., Berlingieri C., Longhi C., Tonin P., Turolla A. Assessment of virtual teacher feedback for the recovery of the upper limb after a stroke. Study protocol for a randomized controlled trial. Med Rehabil 2016; 20(3): 13-20. DOI: 10.5604/01.3001.0009.5010

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