Evaluation and Spectrum of Orbital Diseases

Author(s):  
Raymond S. Douglas ◽  
Robert A. Goldberg

Although orbital disorders are not frequently encountered in the comprehensive ophthalmologist’s practice, it is essential to be able to diagnose patients with orbital disease and manage them accordingly. Various disease processes can affect the orbit. This chapter endeavors to provide a thoughtful, stepwise, and logical approach to the evaluation of orbital disease. The discussion begins with differential diagnosis, adds an intelligent history-taking and physical examination, and then focuses on efficient use of diagnostic tests to finally arrive at the correct diagnosis. The staging and management of two common orbital disorders, orbital inflammation and thyroid-associated ophthalmopathy, will also be discussed. The differential diagnosis of orbital disease is extensive, and most listings of orbital disease divide the causes between histopathologic and mechanistic categories. This type of grouping is intellectually sound and scientifically useful but does not provide a framework that the clinical practitioner can easily grasp and directly use in sorting through the differential diagnosis of any given patient. In broad terms, orbital disease can be considered in terms of location, extent, and biologic activity. The classification used in this chapter is broken down along clinical lines and takes advantage of the fact that the orbit has a somewhat limited repertoire of ways that it can respond to pathologic conditions. Orbital disease can be categorized into five basic clinical patterns: inflammatory, mass effect, structural, vascular, and functional. Although many cases cross over into several categories, the vast majority of clinical presentations fit predominantly into one of these patterns. As the clinician walks through each step of the evaluation process—history, physical examination, laboratory testing, orbital imaging—a conscious effort should be made to categorize the presentation within this framework. If the practitioner approaches orbital disease with this framework of discrete patterns of clinical presentation, then at every step of the diagnostic pathway (history, physical examination, orbital imaging studies, and special tests), he or she can draw from a defined set of differential diagnoses that characterize each pattern of orbital disease and use that information to efficiently and confidently orchestrate diagnosis and management.

Author(s):  
Yukiko Kimura ◽  
Taunton R. Southwood

This chapter presents a systematic approach to evaluating the limping child, beginning with a careful history, then the physical examination, and proceeding to the musculoskeletal examination followed by targeted investigations. Tables with useful tips for differential diagnosis based on age and laboratory testing, as well as diagnostic algorithms, are presented.


CJEM ◽  
2019 ◽  
Vol 21 (3) ◽  
pp. 435-437
Author(s):  
Chelsea R. Beaton ◽  
Clinton Meyer

Learning Points:•Know and identify clinical presentations of toxic alcohols.•Understand the differential diagnosis of high anion gap metabolic acidosis.•Appreciate the importance of history and clinical findings in establishing methanol toxicity diagnoses, especially in centres where laboratory testing is unavailable.•Recognize the value of provincial poison centres in supporting emergency physicians in the diagnosis and management of poisonings and overdoses.


Author(s):  
Yukiko Kimura ◽  
Taunton R. Southwood

This chapter presents a systematic approach to evaluating the limping child, beginning with a careful history, then the physical examination, and proceeding to the musculoskeletal examination followed by targeted investigations. Tables with useful tips for differential diagnosis based on age and laboratory testing, as well as diagnostic algorithms, are presented.


Chest Imaging ◽  
2019 ◽  
pp. 435-439
Author(s):  
Juliana Bueno

A micronodule is a rounded opacity that measures < 3 mm in diameter at CT. Nodules can be located within the lung interstitium, the airspace or both. The differential diagnosis of diseases manifesting with interstitial micronodules varies widely, and affected patients have variable clinical presentations. Familiarity with the anatomy of the pulmonary interstitium is fundamental when assessing micronodules as a concentration of micronodules within a particular compartment may be the imaging clue to the correct diagnosis. Thin-section CT and HRCT are optimal for detection and characterization of pulmonary micronodules; once micronodules are identified, their distribution within the pulmonary interstitium must be determined according to their location with respect to the secondary pulmonary lobule, and characterized as centrilobular, perilymphatic or random.


2006 ◽  
Vol 121 (2) ◽  
pp. 166-169 ◽  
Author(s):  
N Shoman ◽  
N Longridge

Positional and positioning vertigo and nystagmus syndromes are usually due to peripheral vestibular dysfunction. The most common form is benign paroxysmal positioning. In this paper, we discuss more serious aetiologies in the differential diagnosis for patients presenting with a history suggestive of benign paroxysmal positioning vertigo. We draw attention to the diagnosis of cerebellar vermis lesions and tumours of the fourth ventricle by presenting two cases of patients with positional nystagmus of so called benign paroxysmal type. We review the literature on positional nystagmus, highlighting key findings on history and physical examination to aid in the correct diagnosis of benign paroxysmal positioning vertigo, and to differentiate it from the rare yet sinister central aetiologies that can present with positional vertigo of the benign positional type. This is with the aim to avoid over-investigating a common presentation without missing a serious diagnosis.


2018 ◽  
pp. 322-326
Author(s):  
Christopher M. Perry

This chapter examines compartment syndrome as it may be evaluated in the field with limited resources, as well as clinical correlations for compartment syndrome evaluation in a more common civilian trauma setting. It reviews the situations in which one might suspect compartment syndrome, explaining the clinical symptoms, physical examination, differential diagnosis, relevant laboratory testing, and imaging to consider when initially evaluating a patient for possible compartment syndrome, including crush injuries and rhabdomyolysis. Additionally, it discusses indications for measuring compartment pressure and best practices for utilizing commercially available equipment. There is a discussion of fasciotomy indications and recommendations regarding pressure measurement techniques. Finally, there is a brief discussion of practices that are not recommended when treating compartment syndrome.


2016 ◽  
Vol 12 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Katie Ekberg ◽  
Markus Reuber

There are many areas in medicine in which the diagnosis poses significant difficulties and depends essentially on the clinician’s ability to take and interpret the patient’s history. The differential diagnosis of transient loss of consciousness (TLOC) is one such example, in particular the distinction between epilepsy and ‘psychogenic’ non-epileptic seizures (NES) is often difficult. A correct diagnosis is crucial because it determines the choice of treatment. Diagnosis is typically reliant on patients’ (and witnesses’) descriptions; however, conventional methods of history-taking focusing on the factual content of these descriptions are associated with relatively high rates of diagnostic errors. The use of linguistic methods (particularly conversation analysis) in research settings has demonstrated that these approaches can provide hints likely to be useful in the differentiation of epileptic and non-epileptic seizures. This paper explores to what extent (and under which conditions) the findings of these previous studies could be transposed from a research into a routine clinical setting.


2021 ◽  
Vol 38 (02) ◽  
pp. 167-175
Author(s):  
Leigh C. Casadaban ◽  
John M. Moriarty ◽  
Cheryl H. Hoffman

AbstractSystematic and standardized evaluation of superficial venous disease, guided by knowledge of the various clinical presentations, venous anatomy, and pathophysiology of reflux, is essential for appropriate diagnosis and optimal treatment. Duplex ultrasonography is the standard for delineating venous anatomy, detecting anatomic variants, and identifying the origin of venous insufficiency. This article reviews tools and techniques essential for physical examination and ultrasound assessment of patients with superficial venous disease.


2021 ◽  
Vol 10 (14) ◽  
pp. 3144
Author(s):  
Danilo L. Andrade ◽  
Marina C. Viana ◽  
Sandro C. Esteves

The differential diagnosis between obstructive and nonobstructive azoospermia is the first step in the clinical management of azoospermic patients with infertility. It includes a detailed medical history and physical examination, semen analysis, hormonal assessment, genetic tests, and imaging studies. A testicular biopsy is reserved for the cases of doubt, mainly in patients whose history, physical examination, and endocrine analysis are inconclusive. The latter should be combined with sperm extraction for possible sperm cryopreservation. We present a detailed analysis on how to make the azoospermia differential diagnosis and discuss three clinical cases where the differential diagnosis was challenging. A coordinated effort involving reproductive urologists/andrologists, geneticists, pathologists, and embryologists will offer the best diagnostic path for men with azoospermia.


2013 ◽  
Vol 10 (1) ◽  
pp. 108-110 ◽  
Author(s):  
Hussein M. Ghanem ◽  
Andrea Salonia ◽  
Antonio Martin-Morales

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