Neurobiological susceptibility to peer influence in adolescence

Author(s):  
Kathy T. Do ◽  
Mitchell J. Prinstein ◽  
Eva H. Telzer

Peers have a profound impact on shaping adolescents’ attitudes and norms about the consequences of engaging in health risk behaviors. However, not all adolescents are equally susceptible to peer influence. Thus, a question that remains unanswered is whether there are potential biomarkers that index an individual’s level of susceptibility to peer environments. The present review considers emerging evidence on the construct of peer influence susceptibility and proposes neurobiological biomarkers that might render some adolescents more susceptible to peer influence than others. Using a differential susceptibility framework, this chapter discusses how individual variation in peer influence susceptibility interacts with different types of peer environments (e.g., risk-promoting versus risk-averse) to predict shifts in adolescent behavior. This perspective suggests that a heightened susceptibility to peer influence may not only increase maladaptive, antisocial behavior in negative peer environments, but may also promote adaptive, prosocial behavior in positive peer environments.

2010 ◽  
Author(s):  
N. H. Shilubane ◽  
Rob Ruiter ◽  
B. H. W. van den Borne ◽  
P. S. Reddy

2021 ◽  
Vol 7 (3) ◽  
pp. 38
Author(s):  
Alexandra Korotaeva ◽  
Danzan Mansorunov ◽  
Natalya Apanovich ◽  
Anna Kuzevanova ◽  
Alexander Karpukhin

Neuroendocrine neoplasms (NEN) are infrequent malignant tumors of a neuroendocrine nature that arise in various organs. They occur most frequently in the lungs, intestines, stomach and pancreas. Molecular diagnostics and prognosis of NEN development are highly relevant. The role of clinical biomarkers can be played by microRNAs (miRNAs). This work is devoted to the analysis of data on miRNA expression in NENs. For the first time, a search for specificity or a community of their functional characteristics in different types of NEN was carried out. Their properties as biomarkers were also analyzed. To date, more than 100 miRNAs have been characterized as differentially expressed and significant for the development of NEN tumors. Only about 10% of the studied miRNAs are expressed in several types of NEN; differential expression of the remaining 90% was found only in tumors of specific localizations. A significant number of miRNAs have been identified as potential biomarkers. However, only a few miRNAs have values that characterized their quality as markers. The analysis demonstrates the predominant specific expression of miRNA in each studied type of NEN. This indicates that miRNA’s functional features are predominantly influenced by the tissue in which they are formed.


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