scholarly journals Corrigendum to: Capsaicin-Induced Changes in Electrical Pain Perception Threshold Can Be Used to Assess the Magnitude of Secondary Hyperalgesia in Humans

Pain Medicine ◽  
2020 ◽  
Keyword(s):  
Pain Perception ◽  
Secondary Hyperalgesia ◽  
Perception Threshold ◽  
Induced Changes

scholarly journals Capsaicin-Induced Changes in Electrical Pain Perception Threshold Can Be Used to Assess the Magnitude of Secondary Hyperalgesia in Humans

Pain Medicine ◽  
2020 ◽  
Vol 21 (11) ◽  
pp. 2830-2838
Author(s):  
Sam W Hughes ◽  
Meirvaan Basra ◽  
Calvin Chan ◽  
Callum Parr ◽  
Felyx Wong ◽  
...  
Keyword(s):  
Pain Perception ◽  
Rapid Assessment ◽  
Central Zone ◽  
Mechanical Hyperalgesia ◽  
Electrocutaneous Stimulation ◽  
Secondary Hyperalgesia ◽  
Individual Subject ◽  
Perception Threshold ◽  
Pain Thresholds ◽  
Secondary Zone

Abstract Objectives Areas of secondary hyperalgesia can be assessed using quantitative sensory testing (QST). Delivering noxious electrocutaneous stimulation could provide added benefit by allowing multiple measurements of the magnitude of hyperalgesia. We aimed to characterize the use of electrical pain perception (EPP) thresholds alongside QST as a means by which to measure changes in pain thresholds within an area of secondary mechanical hyperalgesia. Methods EPP and heat pain thresholds (HPTs) were measured at five distinct points at baseline and following 1% capsaicin cream application, one within a central zone and four within a secondary zone. Areas of secondary mechanical hyperalgesia were mapped using QST. In a further 14 participants, capsaicin-induced reduction in EPP thresholds was mapped using a radial lines approach across 24 points. Results There was a reduction in EPP threshold measured at the four points within the secondary zone, which was within the mapped area of mechanical secondary hyperalgesia. The magnitude of secondary hyperalgesia could be split into a mild (∼4% reduction) and severe (∼21% reduction) area within an individual subject. There was no reduction in HPT within the secondary zone, but there was a reduction in both HPT and EPP threshold within the primary zone. EPP mapping revealed differences in the magnitude and spread of hyperalgesia across all subjects. Conclusions Measuring capsaicin-induced reduction in EPP thresholds can be used to map hyperalgesic areas in humans. This semi-automated approach allows rapid assessment of the magnitude of hyperalgesia, both within an individual subject and across a study population.

Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans

1997 ◽  
Vol 273 (1) ◽  
pp. G118-G123 ◽  
Author(s):  
M. A. Mesquita ◽  
D. G. Thompson ◽  
L. E. Troncon ◽  
M. D'Amato ◽  
L. C. Rovati ◽  
...  
Keyword(s):  
Double Blind Study ◽  
Receptor Blockade ◽  
Intragastric Pressure ◽  
Double Blind ◽  
Perception Threshold ◽  
Threshold Control ◽  
Gastric Pressure ◽  
Induced Changes ◽  
Perception Score

The purpose of this study was to assess the role of endogenous cholecystokinin (CCK) in regulating fat-induced changes in human gastric relaxation. Proximal gastric pressure-volume relationships were determined in 12 healthy volunteers during a series of gastric distensions, both fasting and after intragastric instillation of 250 ml of 10% Intralipid. All subjects were studied twice, in a randomized, double-blind study, during intravenous infusion of either loxiglumide (CCK-A antagonist) or saline. For each distension, intragastric pressure and compliance were determined together with perception intensity. During saline infusion, Intralipid reduced intragastric pressure (prelipid, 11.7 +/- 0.8; postlipid, 9.7 +/- 0.6 mmHg; P = 0.002) and increased compliance (pressure-volume slope values: prelipid, 87.6 +/- 9.7; postlipid, 47.2 +/- 7; P < 0.01). Loxiglumide infusion during fasting exerted no effect on either intragastric pressure or compliance. After lipid, however, loxiglumide abolished the expected postlipid reduction in intragastric pressure (prelipid, 12.1 +/- 0.7; postlipid, 11.5 +/- 0.8 mmHg; P = 0.4) but did not consistently abolish the postlipid increase in compliance. Loxiglumide exerted no effect on the cumulative perception score or on the volume at perception threshold, although it prevented the fat-induced reduction in pressure at perception threshold [control: prelipid, 15.4 +/- 1.1; postlipid, 10.7 +/- 0.5 (P < 0.05); loxiglumide: prelipid, 13.8 +/- 1.5; postlipid, 12.2 +/- 0.9 (P > 0.05)]. Endogenous CCK or CCK-A receptors therefore play a role in the fat-induced reduction of intragastric pressure and might also modulate gastric perception after lipid.

scholarly journals The Combination Neuroprotective Abilities of Resveratrol and Naringenin in Attenuation of Sleep Deprivation Complications in Rats

2021 ◽  
Vol 10 ◽  
pp. e2315
Author(s):  
Zahra Abbasy ◽  
Hesam Adin Atashi ◽  
Felicia Agatha ◽  
Fatemeh Mirparsa ◽  
Hamid Zaferani Arani ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Pain Perception ◽  
Male Rats ◽  
Ordinary People ◽  
Neuroprotective Effects ◽  
Perception Threshold ◽  
Sd Rats ◽  
Important Health ◽  
Control Sham ◽  
Drug Vehicle

Background: Sleep loss is one of the most important health problems in the world, and about 30 to 40 percent of ordinary people suffer from it. This study aimed to investigate the neuroprotective effects of the combination of resveratrol and naringenin in attenuation of sleep deprivation (SD) complications in rats. Materials and Methods: In this experimental study, 72 Wistar male rats were randomly divided into three main groups, including control, sham, and 7-days SD group. Each of its main groups consisted of three subgroups, including without drug, vehicle, and combination therapy groups (naringenin [100 mg/kg], resveratrol [100 mg/kg]). The day after the latest injection, the fear conditioning memory tests, locomotor activity test, hot plate, and forced swimming tests (FST) were carried out on all rats, and then sham and SD groups were induced 48 hours of non-REM SD (device off and on, respectively) and these behavioral tests were repeated for all rats again. Finally, the brains of all rats were removed and histopathologically examined, and stained with nissl and TUNNEL. Results: To assess fear condition memory, the rate of latency to first freezing in the visual and auditory phase increased in sham and SD rats that received vehicle or no drug (P<0.001), which indicates memory corruption. Injection of the combination of naringenin and resveratrol reduced the latency to first freezing (P<0.001), which means improved memory. In the FST test, injection of naringenin and resveratrol reduced the rate of immobility (P<0.001), which means improved depressive behavior. The naringenin and resveratrol reduced the pain perception threshold. Also, the naringenin and resveratrol reduced apoptosis compared to the control and vehicle groups (P<0.001). Conclusions: The combination of naringenin and resveratrol compared to other groups could improve memory and mood as well as reduce apoptosis, depression, and pain perception threshold. [GMJ.2021;10:e2315]

Pain Pressure Threshold in Cluster Headache Patients

Cephalalgia ◽  
1996 ◽  
Vol 16 (1) ◽  
pp. 62-66 ◽  
Author(s):  
G Bono ◽  
F Antonaci ◽  
G Sandrini ◽  
E Pucci ◽  
G Nappi ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Pain Perception ◽  
Perception Threshold ◽  
Temporal Muscle ◽  
Mean Values ◽  
Pressure Threshold ◽  
Pain Pressure Threshold ◽  
Pressure Algometer ◽  
Symmetrical Points ◽  
Symptomatic Side

Pain perception threshold (PFT) in the head was assessed with a pressure algometer in 58 cluster headache (CH) patients (52M, 6F; 41 episodic and 17 chronic). Fourteen patients in cluster period were retested in remission. Thresholds were assessed at 10 symmetrical points on each side of the head and at the deltoid. Compared with controls ( n = 80), CH patients had lower PPT in the head and in the deltoid. PPT was lower on the symptomatic side than on the non-symptomatic side in patients with episodic CH during a cluster period ( p<0.001) and in patients with chronic CH ( p<0.05). This pattern was more evident during a cluster period than during remission ( p<0.05). A reduced PPT did not correlate with illness duration and pain side. The lowest PPT mean values were found at the anterior and intermediate levels of the temporal muscle on the symptomatic side. These results imply a central mechanism underlying the pathogenesis of CH.

scholarly journals Effect of Progressive Muscle Relaxation on Pain Threshold and Effectiveness of Footballers’ Training

2015 ◽  
Vol 16 (4) ◽  
Author(s):  
Lilianna Jaworska ◽  
Arletta Hawrylak ◽  
Bartosz Burzyński ◽  
Joanna Szczepańska-Gieracha
Keyword(s):  
Pain Threshold ◽  
Pain Perception ◽  
Muscle Relaxation ◽  
Pressure Pain Threshold ◽  
Progressive Muscle Relaxation ◽  
Relaxation Techniques ◽  
Training Methods ◽  
Lumbar Region ◽  
Perception Threshold ◽  
Pressure Therapy

AbstractPurpose. Relaxing in the athlete’s training process is underutilized. Relaxation techniques, however, should be taught from the very beginning of the footballer’s training career. The main aim of this study was to present the effect of progressive muscle relaxation on pressure pain threshold levels and the effectiveness of the footballer’s training. Methods. A sample of 32 football players participated in the therapeutic program consisting of 8 PMR sessions. Before and after applying a pressure therapy, the pain threshold in the lumbar region was measured by a dolorimeter and the Cooper test was carried out to determine the footballers’ level of endurance. Results. PMR training did not increase significantly the pain threshold level in the experimental group (p > 0.05), but it increased significantly the distance covered in the Cooper test (p = 0.04). Analysis of the Spearman rank correlation was also carried out (p = 0.81). Conclusions. PMR does not lower pain perception threshold. PMR therapy increases the distance measured by the Cooper test. In order to determine the role of PMR in injury prevention, further research is necessary.

Pain perception threshold in major depression

1993 ◽  
Vol 34 (10) ◽  
pp. 687-689 ◽  
Author(s):  
Georg Adler ◽  
Wagner F. Gattaz
Keyword(s):  
Major Depression ◽  
Pain Perception ◽  
Perception Threshold

scholarly journals Biopsychosocial Aspects of Atypical Odontalgia

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
A. Ciaramella ◽  
M. Paroli ◽  
L. Lonia ◽  
M. Bosco ◽  
P. Poli
Keyword(s):  
Pain Perception ◽  
Temporomandibular Disorder ◽  
Control Group ◽  
Self Assessment ◽  
Perception Threshold ◽  
Axis Ii ◽  
Clinical Interviews ◽  
Atypical Odontalgia ◽  
C Fibers ◽  
Axis I

Background. A few studies have found somatosensory abnormalities in atypical odontalgia (AO) patients. The aim of the study is to explore the presence of specific abnormalities in facial pain patients that can be considered as psychophysical factors predisposing to AO. Materials and Methods. The AO subjects () have been compared to pain-free (), trigeminal neuralgia (), migraine (), and temporomandibular disorder (). The neurometer current perception threshold (CPT) was used to investigate somatosensory perception. Structured clinical interviews based on the DSM-IV axis I and DSM III-R axis II criteria for psychiatric disorders and self-assessment questionnaires were used to evaluate psychopathology and aggressive behavior among subjects. Results. Subjects with AO showed a lower Aβ, Aδ, and C trigeminal fiber pain perception threshold when compared to a pain-free control group. Resentment was determined to be inversely related to Aβ (rho: 0.62, ), Aδ (rho: 0.53, ) and C fibers (rho: 0.54, ), and depression was inversely related with C fiber (rho: 0.52, ) perception threshold only in AO subjects. Conclusion. High levels of depression and resentment can be considered predictive psychophysical factors for the development of AO after dental extraction.

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