scholarly journals The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis

Pain Medicine ◽  
2019 ◽  
Vol 21 (1) ◽  
pp. 150-160 ◽  
Author(s):  
Larissa J Strath ◽  
Catherine D Jones ◽  
Alan Philip George ◽  
Shannon L Lukens ◽  
Shannon A Morrison ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Knee Osteoarthritis ◽  
Dietary Intervention ◽  
The United States ◽  
Dietary Interventions ◽  
Low Fat ◽  
Functional Pain ◽  
Low Carbohydrate ◽  
Before And After ◽  
Fat Diets

Abstract Objective Osteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the leading causes of disability in older adults. Besides knee replacement, there are no curative treatments for KOA, so persistent pain is commonly treated with opioids, acetaminophen, and nonsteroidal anti-inflammatory drugs. However, these drugs have many unpleasant side effects, so there is a need for alternative forms of pain management. We sought to test the efficacy of a dietary intervention to reduce KOA. Design A randomized controlled pilot study to test the efficacy of two dietary interventions. Subjects Adults 65–75 years of age with KOA. Methods Participants were asked to follow one of two dietary interventions (low-carbohydrate [LCD], low-fat [LFD]) or continue to eat as usual (control [CTRL]) over 12 weeks. Functional pain, self-reported pain, quality of life, and depression were assessed every three weeks. Serum from before and after the diet intervention was analyzed for oxidative stress. Results Over a period of 12 weeks, the LCD reduced pain intensity and unpleasantness in some functional pain tasks, as well as self-reported pain, compared with the LFD and CTRL. The LCD also significantly reduced oxidative stress and the adipokine leptin compared with the LFD and CTRL. Reduction in oxidative stress was related to reduced functional pain. Conclusions We present evidence suggesting that oxidative stress may be related to functional pain, and lowering it through our LCD intervention could provide relief from pain and be an opioid alternative.

Abstract MP63: Randomized Trials of Low-Fat vs. Other Diet Interventions on Weight Loss: A Meta-Analysis

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Deirdre K Tobias ◽  
Mu Chen ◽  
Walter Willett ◽  
Frank B Hu
Keyword(s):  
Weight Loss ◽  
Randomized Trials ◽  
Dietary Intervention ◽  
Meta Analysis ◽  
Dietary Interventions ◽  
Low Fat ◽  
Intervention Intensity ◽  
Low Carbohydrate ◽  
Fat Diets

Introduction: The effectiveness of low-fat diets for weight loss has been debated for decades. Dozens of randomized control trials (RCTs) have assessed whether decreasing the intake of total fat leads to weight loss, giving mixed results. Hypothesis: We hypothesized that low-fat dietary interventions do not lead to greater weight loss when comparator diet intervention intensity is considered. Methods: We conducted a systematic review and meta-analysis. RCTs were included if they compared a low-fat dietary intervention to any control diet with at least 1 year of follow-up. We estimated the combined fixed effect inverse variance weighted mean difference of low-fat vs. comparison diets. Several a priori stratified analyses were considered to explore heterogeneity. Results: Fifty studies met inclusion criteria, reporting 1-10 years of follow-up on 70,054 participants. Overall, low-fat dietary interventions resulted in 0.51kg greater weight loss compared to other diets (95% CI = -0.62, -0.40, p<0.001; I2 = 83%). However, when trials where greater attention was given to the low-fat group were excluded, comparator diets led to greater weight loss than low-fat diets (n=30; WMD=0.87, 95% CI=0.56, 1.17, p<0.001). Similarly, when the type of comparator diet was considered, low-fat diets were only beneficial compared to control groups who were simply asked to maintain their usual diet (n=18; WMD = -1.03, 95% CI = -1.18, -0.88, p<0.001). When equal attention was given to intervention groups, low-carbohydrate diets (n=15; WMD = 1.13kg, 95% CI = 0.53, 1.73, p<0.001) and other “healthy” diets without a low-fat component (n=20; WMD = 0.77kg, 95% CI = 0.42, 1.13, p<0.001) led to greater weight loss than low-fat diets. Comparison diets, irrespective of type, were associated with 1.30kg greater weight loss than low-fat diets when the interventions were intended to be isocaloric (n=19; 95% CI = 0.92, 1.69, p<0.001). Conclusions: Low-fat dietary interventions are not more effective than other diets for weight loss when differences in intervention intensity between treatment groups are considered. Rather, evidence from long-term (>=1 year) randomized trials indicates low-carbohydrate or other healthful dietary pattern interventions without a low-fat focus may be more effective for weight loss than low-fat dietary interventions. Further evidence is needed to establish the role of these interventions in longer-term weight loss and weight maintenance.

scholarly journals Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. A Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139817 ◽  
Author(s):  
Jonathan Sackner-Bernstein ◽  
David Kanter ◽  
Sanjay Kaul
Keyword(s):  
Dietary Intervention ◽  
Meta Analysis ◽  
Low Fat ◽  
Obese Adults ◽  
Low Carbohydrate ◽  
Fat Diets

Effects of Low-Carbohydrate and Low-Fat Diets

2015 ◽  
Vol 162 (5) ◽  
pp. 392
Author(s):  
Murray Skeaff ◽  
Jim Mann ◽  
Lisa Te Morenga ◽  
Rachael McLean
Keyword(s):  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

Effects of Low-Carbohydrate and Low-Fat Diets

2015 ◽  
Vol 162 (5) ◽  
pp. 391
Author(s):  
Alberto Donzelli ◽  
Alessandra Lafranconi
Keyword(s):  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

scholarly journals Effects of dietary fat modification on oxidative stress and inflammatory markers in the LIPGENE study

2010 ◽  
Vol 104 (9) ◽  
pp. 1357-1362 ◽  
Author(s):  
Helena Petersson ◽  
Ulf Risérus ◽  
Jolene McMonagle ◽  
Hanne L. Gulseth ◽  
Audrey C. Tierney ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dietary Fat ◽  
Dietary Intervention ◽  
Stress Indicator ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Markers Of Oxidative Stress ◽  
Fat Diets ◽  
The Impact ◽  
And Oxidative Stress

Subjects with the metabolic syndrome (MetS) have enhanced oxidative stress and inflammation. Dietary fat quality has been proposed to be implicated in these conditions. We investigated the impact of four diets distinct in fat quantity and quality on 8-iso-PGF2α (a major F2-isoprostane and oxidative stress indicator), 15-keto-13,14-dihydro-PGF2α (15-keto-dihydro-PGF2α, a major PGF2α metabolite and marker of cyclooxygenase-mediated inflammation) and C-reactive protein (CRP). In a 12-week parallel multicentre dietary intervention study (LIPGENE), 417 volunteers with the MetS were randomly assigned to one of the four diets: two high-fat diets (38 % energy (%E)) rich in SFA or MUFA and two low-fat high-complex carbohydrate diets (28 %E) with (LFHCC n-3) or without (LFHCC) 1·24 g/d of very long chain n-3 fatty acid supplementation. Urinary levels of 8-iso-PGF2α and 15-keto-dihydro-PGF2α were determined by RIA and adjusted for urinary creatinine levels. Serum concentration of CRP was measured by ELISA. Neither concentrations of 8-iso-PGF2α and 15-keto-dihydro-PGF2α nor those of CRP differed between diet groups at baseline (P>0·07) or at the end of the study (P>0·44). Also, no differences in changes of the markers were observed between the diet groups (8-iso-PGF2α, P = 0·83; 15-keto-dihydro-PGF2α, P = 0·45; and CRP, P = 0·97). In conclusion, a 12-week dietary fat modification did not affect the investigated markers of oxidative stress and inflammation among subjects with the MetS in the LIPGENE study.

scholarly journals Comparative Effects of Low-Carbohydrate High-Protein Versus Low-Fat Diets on the Kidney

2012 ◽  
Vol 7 (7) ◽  
pp. 1103-1111 ◽  
Author(s):  
Allon N. Friedman ◽  
Lorraine G. Ogden ◽  
Gary D. Foster ◽  
Samuel Klein ◽  
Richard Stein ◽  
...  
Keyword(s):  
High Protein ◽  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets ◽  
Protein Versus

Effects of Low-Carbohydrate and Low-Fat Diets

2015 ◽  
Vol 162 (5) ◽  
pp. 391
Author(s):  
Stephen F. Burns ◽  
Masashi Miyashita
Keyword(s):  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

scholarly journals Very Low-Carbohydrate and Low-Fat Diets Affect Fasting Lipids and Postprandial Lipemia Differently in Overweight Men

2004 ◽  
Vol 134 (4) ◽  
pp. 880-885 ◽  
Author(s):  
Matthew J. Sharman ◽  
Ana L. Gómez ◽  
William J. Kraemer ◽  
Jeff S. Volek
Keyword(s):  
Postprandial Lipemia ◽  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets

Effects of Low-Carbohydrate and Low-Fat Diets

2015 ◽  
Vol 162 (5) ◽  
pp. 392 ◽  
Author(s):  
Gaetano Santulli
Keyword(s):  
Low Fat ◽  
Low Carbohydrate ◽  
Fat Diets
Sign in / Sign up

Export Citation Format

Share Document