Corneal Densitometry Changes after Epithelium-Off Corneal Collagen Crosslinking

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Karim N Abbas ◽  
Raafat A. El Sayed ◽  
Mouamen M Mostafa
Keyword(s):  
Prospective Observational Study ◽  
Corneal Stroma ◽  
Collagen Matrix ◽  
Significant Elevation ◽  
The Past ◽  
Corneal Densitometry ◽  
Post Surgery ◽  
Corneal Collagen Crosslinking ◽  
Stromal Layer ◽  
Corneal Collagen

Abstract Background Keratoconus is a progressive non-inflammatory, degenerative disease that affects the integrity of the collagen matrix within the corneal stroma. Corneal cross-linking (CXL) has been described as the only modality in halting the disease progression over the past decade. Aim of the Work To compare the change in corneal densitometry before and 6 months after CXL using our unique protocol. Patients and Methods A prospective observational study was conducted on 30 eyes of 30 patients with progressive keratoconus. Epitheliumoff CXL was done with application of Riboflavin (VibeX RapidTM) for 6 minutes at a rate of 1 drop/ minute. UVA was delivered using the Avedro KXL machine (Avedro, Waltham, MA, USA) using the following parameters: 7.2 joules, 12 milli watt/ minute and 10 minutes of accelerated continuous UV delivery. Results Within the anterior (120 um) stromal layer, the concentric zones (0 to 2 mm) and (2 to 6 mm) showed a significant elevation of mean densitometry 6 months post-surgery (P = 0.020) and (P = 0.023) respectively compared to the baseline, However the concentric zones (6 to 10 mm) and (10 to 12 mm) showed a non-significant elevation of mean densitometry 6 months post-surgery (P = 0.167) and (P = 0.234) respectively compared to the baseline. Conclusion There is a significant increase in corneal densitometry 6 months postsurgery of the anterior stromal layer within the central 6 mm zone.

Experimental and morphological reasoning for the use of corneal crosslinking during keratoplasty in small domestic animals

2020 ◽  
Vol 1 (12) ◽  
pp. 12-21
Author(s):  
N. A. Slesarenko ◽  
◽  
A. G. Shilkin ◽  
U. E. Lukashina ◽  
◽  
...  
Keyword(s):  
Postoperative Period ◽  
Clinical Observation ◽  
Corneal Stroma ◽  
Collagen Matrix ◽  
Domestic Animals ◽  
Demarcation Line ◽  
Collagen Crosslinking ◽  
Corneal Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

The article reflects the influence of corneal collagen crosslinking on changes in the morphofunctional signs of the corneal stroma. Data on changes in the anterior layers of the stroma, which are expressed by a compact packing of fibers without signs of even minimal edema, as well as a demarcation line separating the area of impact from the indifferent zone, are scientifically substantiated. Clinical observation of cats and dogs after keratoplasty using a crosslinking modified cornea showed the most favorable course of the postoperative period which was expressed in an increase in the resistance of the collagen matrix of the donor tissue to collagenases which is especially important when using large and giant transplants.

scholarly journals Anterior and posterior corneal stroma elasticity after corneal collagen crosslinking treatment

2013 ◽  
Vol 116 ◽  
pp. 58-62 ◽  
Author(s):  
Janice Dias ◽  
Vasilios F. Diakonis ◽  
Vardhaman P. Kankariya ◽  
Sonia H. Yoo ◽  
Noël M. Ziebarth
Keyword(s):  
Corneal Stroma ◽  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

scholarly journals Long-term results of corneal collagen crosslinking for recurrent corneal erosion

2021 ◽  
Vol 14 (1) ◽  
pp. 15-24
Author(s):  
Sergey A. Novikov ◽  
Natalya V. Tkachenko ◽  
Oleg A. Frolov ◽  
Akhmed S. Seyfeddin
Keyword(s):  
Corneal Stroma ◽  
Long Term Results ◽  
Amniotic Membrane Transplantation ◽  
Cross Linking ◽  
Professional Activities ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion ◽  
Weak Points ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen

BACKGROUND: Recurrent corneal erosion (RCE) is characterized by excacerbation and remission episodes, reduced patients quality of life affecting their daily and professional activities. In case of conservative therapy inefficacy surgical procedures are used (Bowmans membrane polishing with diamond drill, excimer laser phototherapeutic keratectomy, anterior stromal puncture, and amniotic membrane transplantation). All methods have their advantages and weak points, as well as a certain percent of recurrence. In this regard the use of corneal collagen cross-linking is of the interest as an alternative method of the RCE surgical treatment. MATERIALS AND METHODS: 18 patients (20 eyes) with RCE without central corneal stroma scars, aged from 30 to 66 (average 49,5 10,6, all women), after conservative treatment failure (more than 6 months) underwent cross-linking according to the Dresden protocol with the UVX device, version 1000, by IROC INNOCROSS (Switzerland). RESULTS: All patients were asymptomatic and had no recurrence during the observation period (from 1 to 6 years, in average 2,6 1,6). There was a slight but statistically significant BCVA improvement (from 0,93 0,09 at baseline to 0,97 0,07 after intervention). CONCLUSIONS: Crosslinking may be an additional and effective treatment in a number of RCE cases when there is no central corneal stromal scars present. To reduce stromal keratocytes alteration during the procedure modified protocols may be used.

scholarly journals MyoRing Implantation with and without Corneal Collagen Crosslinking for the Management of Keratoconus

2020 ◽  
Author(s):  
Mehrdad Mohammadpour ◽  
Ahmad Masoumi ◽  
Mahmoud Dehghan ◽  
Mohammad Nasser Hashemian ◽  
Shahab Addin Karami ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Corneal Stroma ◽  
Safety And Efficacy ◽  
Collagen Crosslinking ◽  
Randomized Controlled ◽  
Uncorrected Distance Visual Acuity ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose: To evaluate the safety and efficacy of femtosecond laser-assisted MyoRing implantation with concurrent corneal collagen crosslinking (CXL) compared to MyoRing alone for the treatment of progressive keratoconus. Methods: A total of 60 patients were enrolled in this randomized controlled trial. The patients were randomly allocated into two groups. In the first group, MyoRing was implanted, while in the second, it was inserted in the corneal stroma using the same technique, along with simultaneous CXL. Visual, refractive, topographic, and abberometric outcomes were measured preoperatively and at every postoperative visit. Results: Data of 47 patients were available at the end of the study; 28 in the MyoRing group and 19 in the MyoRing + CXL group. The mean uncorrected distance visual acuity (UDVA) improved from 0.79 ± 0.39 logMAR to 0.52 ± 0.31 logMAR (P < 0.05) in the MyoRing + CXL group and from 0.65 ± 0.38 logMAR to 0.62 ± 0.23 logMAR (P = 0.70) in the MyoRing group. CDVA changed from 0.33 ± 0.19 logMAR to 0.25 ± 0.16 logMAR (P = 0.10) in the MyoRing + CXL group and 0.32 ± 0.22 logMAR to 0.33 ± 0.17 logMAR (P > 0.5) in the MyoRing group. The mean keratometry (Km) decreased from 47.5 ± 2.7 D to 43.8 ± 3.2 D (P < 0.001) in the MyoRing group and 49.3 ± 3.4 D to 45.1 ± 3.0 D (P < 0.001) in the MyoRing + CXL group. Besides, horizontal coma was significantly lower in the MyoRing + CXL group (P = 0.022). Conclusion: MyoRing insertion combined with CXL is a safe and effective method for the treatment of keratoconus. The visual and topographic outcomes were comparable to that for MyoRing insertion after 10 months; however, horizontal coma was significantly lower in the MyoRing + CXL group.

scholarly journals Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Deepa Viswanathan ◽  
Nikhil L. Kumar ◽  
John J. Males
Keyword(s):  
Young Patients ◽  
Ultraviolet A ◽  
Effective Treatment Option ◽  
Collagen Crosslinking ◽  
Paediatric Patients ◽  
Corneal Grafting ◽  
Minimum Angle ◽  
Corneal Collagen Crosslinking ◽  
The Mean ◽  
Corneal Collagen

Purpose. To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients.Methods. This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min).Results. The mean patient age was 14.3 ± 2.4 years (range 8–17) and mean followup duration was 20.1 ± 14.25 months (range 6–48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51).Conclusions. Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.

scholarly journals Intrastromal corneal rings and corneal collagen crosslinking for progressive keratoconus: comparison of two sequences

Eye ◽  
2014 ◽  
Vol 29 (2) ◽  
pp. 294-295 ◽  
Author(s):  
N Saib ◽  
S Bonnel ◽  
J-R Fenolland ◽  
M Abrieu ◽  
C Rambaud ◽  
...  
Keyword(s):  
Collagen Crosslinking ◽  
Corneal Collagen Crosslinking ◽  
Corneal Collagen
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