306. A MULTICENTRE RELIABILITY AND VALIDITY STUDY OF LASER SPECKLE CONTRAST IMAGING AND THERMOGRAPHY IN PATIENTS WITH RAYNAUD’S PHENOMENON SECONDARY TO SYSTEMIC SCLEROSIS

Rheumatology ◽  
2017 ◽  
Vol 56 (suppl_2) ◽  
Author(s):  
Andrea K. Murray ◽  
Joanne Manning ◽  
Tonia Moore ◽  
Jack Wilkinson ◽  
Elizabeth Marjanovic ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Raynaud’S Phenomenon ◽  
Reliability And Validity ◽  
Raynaud's Phenomenon ◽  
Laser Speckle ◽  
Validity Study ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

scholarly journals Use of Laser Speckle Contrast Imaging to Assess Digital Microvascular Function in Primary Raynaud Phenomenon and Systemic Sclerosis: A Comparison Using the Raynaud Condition Score Diary

2015 ◽  
Vol 42 (7) ◽  
pp. 1163-1168 ◽  
Author(s):  
John D. Pauling ◽  
Jacqueline A. Shipley ◽  
Darren J. Hart ◽  
Anita McGrogan ◽  
Neil J. McHugh
Keyword(s):  
Systemic Sclerosis ◽  
Objective Assessment ◽  
Microvascular Function ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Raynaud Phenomenon ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Condition Score ◽  
Cold Challenge

Objective.Evaluate objective assessment of digital microvascular function using laser speckle contrast imaging (LSCI) in a cross-sectional study of patients with primary Raynaud phenomenon (RP) and systemic sclerosis (SSc), comparing LSCI with both infrared thermography (IRT) and subjective assessment using the Raynaud Condition Score (RCS) diary.Methods.Patients with SSc (n = 25) and primary RP (n = 18) underwent simultaneous assessment of digital perfusion using LSCI and IRT with a cold challenge on 2 occasions, 2 weeks apart. The RCS diary was completed between assessments. The relationship between objective and subjective assessments of RP was evaluated. Reproducibility of LSCI/IRT was assessed, along with differences between primary RP and SSc, and the effect of sex.Results.There was moderate-to-good correlation between LSCI and IRT (Spearman rho 0.58–0.84, p < 0.01), but poor correlation between objective assessments and the RCS diary (p > 0.05 for all analyses). Reproducibility of IRT and LSCI was moderate at baseline (ICC 0.51–0.63) and immediately following cold challenge (ICC 0.56–0.86), but lower during reperfusion (ICC 0.3–0.7). Neither subjective nor objective assessments differentiated between primary RP and SSc. Men reported lower median daily frequency of RP attacks (0.82 vs 1.93, p = 0.03). Perfusion using LSCI/IRT was higher in men for the majority of assessments.Conclusion.Objective and subjective methods provide differing information on microvascular function in RP. There is good convergent validity of LSCI with IRT and acceptable reproducibility of both modalities. Neither subjective nor objective assessments could differentiate between primary RP and SSc. Influence of sex on subjective and objective assessment of RP warrants further evaluation.

scholarly journals Nephron blood flow dynamics measured by laser speckle contrast imaging

2011 ◽  
Vol 300 (2) ◽  
pp. F319-F329 ◽  
Author(s):  
Niels-Henrik Holstein-Rathlou ◽  
Olga V. Sosnovtseva ◽  
Alexey N. Pavlov ◽  
William A. Cupples ◽  
Charlotte Mehlin Sorensen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Signal Transmission ◽  
Experimental Studies ◽  
Flow Dynamics ◽  
Laser Speckle ◽  
Tubuloglomerular Feedback ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Blood Flow Dynamics

Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50–100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.

scholarly journals Laser speckle contrast imaging for perfusion monitoring during surgical reconstruction of anorectal malformations

2021 ◽  
Vol 66 ◽  
pp. 101793
Author(s):  
Pernilla Stenström ◽  
Rafi Sheikh ◽  
Kristine Hagelsteen ◽  
Johanna Wennström Berggren ◽  
Malin Malmsjö
Keyword(s):  
Anorectal Malformations ◽  
Laser Speckle ◽  
Surgical Reconstruction ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

scholarly journals Monitoring microvascular perfusion variations with laser speckle contrast imaging using a view-based temporal template method

2017 ◽  
Vol 111 ◽  
pp. 49-59 ◽  
Author(s):  
Mohammad Zaheer Ansari ◽  
Eun-Jeung Kang ◽  
Mioara D. Manole ◽  
Jens P. Dreier ◽  
Anne Humeau-Heurtier
Keyword(s):  
Laser Speckle ◽  
Microvascular Perfusion ◽  
Template Method ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

Enhancing vascular visualization in laser speckle contrast imaging of blood flow using multi-focus image fusion

2018 ◽  
Vol 12 (1) ◽  
pp. e201800100 ◽  
Author(s):  
Wenzhi Lv ◽  
Yang Wang ◽  
Xiao Chen ◽  
Xiaoxi Fu ◽  
Jinling Lu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Image Fusion ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Focus Image
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