scholarly journals Performance of magnetic resonance imaging in the diagnosis of axial spondyloarthritis: a systematic literature review

Rheumatology ◽  
2019 ◽  
Vol 58 (11) ◽  
pp. 1955-1965 ◽  
Author(s):  
Alexis Jones ◽  
Timothy J P Bray ◽  
Peter Mandl ◽  
Margaret A Hall-Craggs ◽  
Helena Marzo-Ortega ◽  
...  

Abstract Objectives To summarize the evidence on the performance of MRI for the diagnosis of axial SpA. Methods This was a systematic literature review of all studies from January 2013 to March 2017 including adult patients with clinically suspected axial SpA undergoing MRI. Studies from a previously published systematic literature review up to January 2013 were also included. Results Thirty-one studies were included. Six studies demonstrated good sensitivity and specificity for SI joint (SIJ) bone marrow oedema (BMO). Specificity was increased by the presence of other structural lesions alongside BMO, particularly erosions or fat infiltration. Four studies addressed the utility of SIJ fat infiltration, finding good sensitivity but poor specificity. SIJ erosions showed good specificity in five studies. Studies addressing high T1 signal in the SIJ, fluid signal in the SIJ, ankylosis, sclerosis, capsulitis, backfill and vacuum phenomenon reported limited diagnostic value. In the spine, four studies reported moderate sensitivity and specificity for corner inflammatory lesions, and four reported poor sensitivity and specificity for spinal fat infiltration. Five studies evaluated the added value of spinal MRI over SIJ MRI alone, with variable results depending on the cohort. Six studies addressed the effect of acquisition parameters on diagnostic accuracy: fat-saturated T2-weighted imaging and short tau inversion recovery (STIR) imaging showed comparable utility in identifying BMO. Three studies showed that gadolinium was of minimal added value in the detection of BMO. Conclusions These results confirmed the diagnostic utility of MRI in axial SpA. Performance varied according to the characteristics of the cohort and the number and combination of MRI lesions considered.

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Lidwine Spoormans ◽  
Ana Pereira Roders

PurposeAlthough residential neighbourhoods are the largest and most resilient share of a city and the process of urban conservation and renewal is ongoing, methods to assess their values are limited. This paper presents the results of a systematic literature review, revealing the state of the art and its knowledge gaps with regard to methods for assessing values of architecture in residential neighbourhoods.Design/methodology/approachThe systematic literature review is based on studies selected by a research protocol, using a digital database of peer-reviewed literature. A metanarrative approach is used to synthesise the qualitative data from reviewed articles. This review has two stages: (1) giving an overview of the field and (2) categorising research methods and disciplines.FindingsThe review revealed a wide variety of studies from different disciplines and deduced its key trends, titled as “storylines”, concerning the methods to assess significance, integrating a broader scope of values and different perspectives. In particular, the “storylines” outside traditional heritage disciplines offer methods to include more stakeholders, link value assessment to policy development or highlight heritage potential. Results reveal the diversity in concepts and strengthen the need for an interdisciplinary vocabulary on values and methods, enabling planners and policymakers to compare their results and help to create more attractive and resilient cities.Originality/valueBy reviewing and comparing the selected studies from a wider range of disciplines and research fields, this paper shares insights into the complementary characteristics of the different types of value research, outlining the added value of the different perspectives.


2021 ◽  
Vol 14 (2) ◽  
pp. 133-151
Author(s):  
Erika Puspita Sari ◽  
Dwi Cahyono ◽  
Rendy Mirwan Aspirandi

The value of the company has an important role in describing the level of public trust in a company. The purpose of this literature review is to determine the factors that affect the value of BUMN companies and how to solve them. A systematic study was carried out using a Systematic Literature Review approach in journals published from 2016 to 2020 which concluded that the value of BUMN companies in Indonesia was still low in their management capabilities. The causes of the low value of BUMN companies include 1) BUMN companies that do not pay attention to the components of intellectual capital they have, 2) excessive debt 3) Weak implementation of GCG 4) the occurrence of deviations by BUMN directors and 5) exposure and other risks. The solution to overcome this problem is that state-owned companies must create a competitive advantage so that market perceptions will increase and the company can survive in a dynamic business environment. How: 1) By utilizing all potential resources, namely human capital, physical capital, and structural capital to generate added value. 2) managing as efficiently and effectively as possible in order to generate profits as expected by investors and 3) making specific GCG practice guidelines for SOEs and 4) implementing debt policies, hedging and risk management such as financial risks, market risks and business risks . That way the company is not burdened by the weakening of the rupiah exchange rate against debt risk and is able to manage foreign currency assets.   Keywords: Systematic Literature Review; Value of BUMN Companies


2020 ◽  
Vol 48 (5) ◽  
pp. 030006052092353
Author(s):  
Hua Zhong ◽  
Heming Wu ◽  
Zhikang Yu ◽  
Qunji Zhang ◽  
Qingyan Huang

Objective We evaluated clinical performance of the T-SPOT.TB test for detecting tuberculosis (TB) infection in Meizhou, China. Methods We enrolled 2,868 patients who underwent T-SPOT.TB, smear, and TB-DNA at the same time. The tests’ sensitivity and specificity were evaluated and compared in different groups, and in pulmonary TB (PTB) and extrapulmonary TB (EPTB) subgroups. Receiver operator characteristic (ROC) curve analysis was used to evaluate T-SPOT.TB’s diagnostic value and determine its cutoff value. Results T-SPOT.TB, TB-DNA, and sputum smear sensitivity was 61.44%, 37.12%, and 14.02%; and specificity was 76.49%, 99.20% and 99.60%, respectively. The T-SPOT.TB positive rate was higher in the PTB and EPTB subgroups than in patients with other pulmonary diseases (61.38% and 61.76% vs. 23.34%). The T-SPOT.TB test had better diagnostic accuracy and sensitivity when the positive cutoff value of marker ESAT-6 was 2.5 [area under ROC curve = 0.701, 95%CI 0.687–0.715] and marker CFP-10 was 6.5 [area under ROC curve = 0.669, 95%CI 0.655–0.683]. Conclusion T-SPOT.TB sensitivity was higher than that of TB-DNA or sputum smear, but the specificity was lower. T-SPOT.TB had moderate sensitivity and specificity for diagnosing TB. T-SPOT.TB’s new positive cutoff value may be clinically valuable according to ROC analysis.


2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Titus H. Divala ◽  
Katherine L. Fielding ◽  
Marriott Nliwasa ◽  
Derek J. Sloan ◽  
Ankur Gupta-Wright ◽  
...  

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